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EC Number
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2.1.1.375
metabolism
vesicular stomatitis virus L protein typically modifies the 2'-Oposition of the cap prior to the G-N-7 position and G-N-7 methylation is diminished by pre-2'-O methylation of the substrate RNA. Amino acid substitutions in the C terminus of L that prevent all cap methylation in recombinant VSV partially retain the ability to G-N-7 methylate a pre-2'-O-methylated RNA, therefore uncoupling the effect of substitutions in the C terminus of the L protein on the two methylations. The 2'-O and G-N-7 methylase activities act specifically on RNA substrates that contain the conserved elements of a vesicular stomatitis virus mRNA start at the 5'-terminus
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762505
2.1.1.375
physiological function
enzyme functions for both 2'-O and G-N-7 methylations during RNA cap formation. VSV L typically modifies the 2'-O position of the cap prior to the G-N-7 position and G-N-7 methylation is diminished by pre-2'-O methylation of the substrate RNA. Amino acid substitutions in the C terminus of L that prevent all cap methylation in recombinant vesicular stomatitis virus partially retain the ability to G-N-7 methylate a pre-2'-O-methylated RNA, uncoupling the effect of substitutions in the C terminus of the L protein on the two methylations. The 2'-O and G-N-7 methylase activities act specifically on RNA substrates that contain the conserved elements of a vesicular stomatitis virus mRNA start at the 5' terminus
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761770
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