EC Number   |
General Information |
Reference  |
|---|
    2.7.1.30 | physiological function |
the enzyme is essential for energy metabolism |
-, 721188 |
| 2.7.1.30 | malfunction |
a glycerol kinase knockout strain is incapable to grow on glycerol and shows higher NADPH-dependent xylitol production compared to the wild type strain |
-, 721849 |
| 2.7.1.30 | metabolism |
the enzyme plays an essential role in central and lipid metabolism |
723091 |
| 2.7.1.30 | physiological function |
glycerol kinase expression leads to increased fat storage in H4IIE rat hepatoma cells |
723091 |
| 2.7.1.30 | evolution |
Bacteria and Eukarya have cell membranes with sn-glycerol-3-phosphate (G3P), whereas archaeal membranes contain sn-glycerol-1-phosphate (G1P). Determining the time at which cells with either G3P-lipid membranes or G1P-lipid membranes appeared is important for understanding the early evolution of terrestrial life. Reconstructed molecular phylogenetic trees of G1PDH (G1P dehydrogenase, EgsA/AraM), which is responsible for G1P synthesis and G3PDHs (G3P dehydrogenase, GpsA and GlpA/GlpD), and glycerol kinase (GlpK), which is responsible for G3P synthesis. Together with the distribution of these protein-encoding genes among archaeal and bacterial groups, phylogenetic analyses suggest that GlpA/GlpD in the Commonote (the last universal common ancestor of all extant life with a cellular form, Commonote commonote) acquired EgsA (G1PDH) from the archaeal common ancestor (Commonote archaea) and acquired GpsA and GlpK from a bacterial common ancestor (Commonote bacteria). The Commonote probably possessed a G3P-lipid membrane synthesized enzymatically, after which the archaeal lineage acquires G1PDH followed by the replacement of a G3P-lipid membrane with a G1P-lipid membrane. Detailed overview |
760456 |
| 2.7.1.30 | metabolism |
overview of the stereospecific biosynthetic pathways of glycerol 1-phosphate (G1P) and glycerol 3-phosphate (G3P) |
760456 |
| 2.7.1.30 | physiological function |
glycerol kinase (GlpK) is responsible for sn-glycerol 3-phosphate (G3P) synthesis |
760456 |
| 2.7.1.30 | evolution |
although there are two African human pathogenic Trypanosoma subspecies: Trypanosoma brucei gambiense (Tbg) and Trypanosoma brucei rhodesiense (Tbr), it is reported in that the amino acid sequences of their GKs are exactly identical. Hence, TbgGK represents the glycerol kinase of both subspecies |
760620 |
| 2.7.1.30 | more |
the enzyme uses a common catalytic site for both activities, phosphatase and kinase |
760620 |
| 2.7.1.30 | malfunction |
overexpression of glycerol kinase under oxidative stress with glycerol supplementation leads to enhancement of lipid production in Synechocystis sp. PCC 6803 |
760718 |
