EC Number   |
General Information |
Reference |
|---|
    2.5.1.21 | physiological function |
essential role in embryonic development |
703278 |
| 2.5.1.21 | physiological function |
influence on regulation of cholesterol metabolism |
697143 |
| 2.5.1.21 | physiological function |
SQS play an important regulatory role in phytosterol biosynthetic pathway |
739037 |
| 2.5.1.21 | physiological function |
squalene and botryococcene are branched-chain, triterpene compounds that arise from the head-tohead condensation of two molecules of farnesyl diphosphate to yield 1'-1 and 1'-3 linkages, respectively |
741903 |
| 2.5.1.21 | physiological function |
squalene is biosynthesized via the head-to-head condensation of two molecules of farnesyl diphosphate, which is catalyzed by the single enzyme squalene synthase. Squalene is a precursor of thousands of bioactive triterpenoids |
738718 |
| 2.5.1.21 | physiological function |
squalene synthase catalyses an unusual head-to-head reductive dimerization of two molecules of farnesyl-pyrophosphate in a two-step reaction to form squalene |
-, 722293 |
| 2.5.1.21 | physiological function |
squalene synthase functions as a key regulator in channeling the carbon flux into both the primary and secondary metabolite branches, and squalene synthase may play a regulatory role in directing triterpene intermediates and sterol pathways |
723497 |
| 2.5.1.21 | physiological function |
squalene synthase is the rate-limiting enzyme located at the downstream of cholesterol synthesis pathway |
737480 |
| 2.5.1.21 | physiological function |
the catalytic domain performs the head-to-head dimerization of two molecules of farnesyl diphosphate to form squalene, a 30 carbon isoprenoid oxidized by squalene monooxygenase (Erg1) and cyclized by lanosterol synthase |
737775 |
| 2.5.1.21 | physiological function |
the enzyme is involved in squalene synthesis and sterol metabolism |
739406 |
