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Literature summary for 2.5.1.21 extracted from

  • Kim, Y.S.; Cho, J.H.; Park, S.; Han, J.Y.; Back, K.; Choi, Y.E.
    Gene regulation patterns in triterpene biosynthetic pathway driven by overexpression of squalene synthase and methyl jasmonate elicitation in Bupleurum falcatum (2011), Planta, 233, 343-355.
    View publication on PubMed
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Cloned(Commentary)

Cloned (Comment) Organism
gene BfSS1, overexpression in Bupleurum falcatum using transfection via Agrobacterium tumefaciens strain GV3101 Bupleurum falcatum

Protein Variants

Protein Variants Comment Organism
additional information expression in sense and antisense orientation, phenotypes, overview Bupleurum falcatum

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
47000
-
 x * 47000, about, sequence calculation Bupleurum falcatum

Organism

Organism UniProt Comment Textmining
Bupleurum falcatum Q32R64 gene BfSS1
-

Source Tissue

Source Tissue Comment Organism Textmining
root
-
 Bupleurum falcatum
-

Subunits

Subunits Comment Organism
? x * 47000, about, sequence calculation Bupleurum falcatum

Expression

Organism Comment Expression
Bupleurum falcatum BfSS1 mRNA accumulates ubiquitously in plant organs and markedly increases in roots after treatment with methyl jasmonate, abscisic acid, and ethephon up

General Information

General Information Comment Organism
metabolism squalene synthase catalyzes the first enzymatic step of the central isoprenoid pathway in sterol and triterpenoid biosynthesis Bupleurum falcatum
additional information methyl jasmonate, abscisic acid, and ethephon induce the accumulation of BfSS1 mRNA, overexpression of the BfSS1 gene in the sense orientation in Bupleurum falcatum increases the mRNA accumulation of downstream genes such as squalene epoxidase and cycloartenol synthase but decreases the mRNA levels of beta-amyrin synthase, a triterpene synthase mRNA. Methyljasmonate treatment of transgenic roots overexpressing BfSS1 in the sense orientation fails to stimulate beta-amyrin synthase mRNA accumulation but still enhances saikosaponin and phytosterol production Bupleurum falcatum
physiological function squalene synthase functions as a key regulator in channeling the carbon flux into both the primary and secondary metabolite branches, and squalene synthase may play a regulatory role in directing triterpene intermediates and sterol pathways Bupleurum falcatum