EC Number   |
Expression |
Reference |
|---|
   3.4.21.5 | down |
activated protein C down-regulates thrombin formation through proteolytic inactivation of factor Va by cleavage at Arg506 and Arg306 and of factor VIIIa by cleavage at Arg336 and Arg562 |
709165 |
| 3.4.21.5 | down |
sucrose octasulfate suppresses ex vivo thrombin generation in human plasma both in an heparin cofactor II-dependent and -independent process, the latter possibly involving inhibition of prothrombin activation |
709161 |
| 3.4.21.5 | up |
binding of immunoglobulin G to the Fc receptors of the thrombocytes is paralleled by increased synthesis of thrombin |
707097 |
| 3.4.21.5 | up |
enhancement of thrombin-stimulated migration and gene expression by high glucose, which can be abolished by endogenous protease-activated receptor-4, PAR-4, knockdown |
717167 |
| 3.4.21.5 | up |
oxidative stress or cell signaling perturbations lead to increased expression of thrombin mRNA in brain endothelial cells |
707050 |
