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Literature summary for 3.4.21.5 extracted from

  • Sarilla, S.; Habib, S.Y.; Kravtsov, D.V.; Matafonov, A.; Gailani, D.; Verhamme, I.M.
    Sucrose octasulfate selectively accelerates thrombin inactivation by heparin cofactor II (2010), J. Biol. Chem., 285, 8278-8289.
    View publication on PubMedView publication on EuropePMC

Inhibitors

Inhibitors Comment Organism Structure
Hirudin
-
Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
fibrinogen + H2O Homo sapiens
-
fibrin + fibrinopeptide A + fibrinopeptide B
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
blood plasma
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
chromozym TH + H2O
-
Homo sapiens ? + 4-nitroaniline
-
?
D-phenylalanyl-pipecolyl-L-arginine-4-nitroanilide + H2O
-
Homo sapiens D-phenylalanyl-pipecolyl-L-arginine + 4-nitroaniline
-
?
fibrinogen + H2O
-
Homo sapiens fibrin + fibrinopeptide A + fibrinopeptide B
-
?

Expression

Organism Comment Expression
Homo sapiens sucrose octasulfate suppresses ex vivo thrombin generation in human plasma both in an heparin cofactor II-dependent and -independent process, the latter possibly involving inhibition of prothrombin activation down