EC Number   |
BRENDA No. |
Title |
Journal |
Volume |
Pages |
Year |
Organism |
PubMed ID |
|---|
   3.4.23.46 | 753489 |
2-Substituted-thio-N-(4-substituted-thiazol/1H-imidazol-2-yl)acetamides as BACE1 inhibitors Synthesis, biological evaluation and docking studies |
Eur. J. Med. Chem. |
137 |
462-475 |
2017 |
Homo sapiens |
28624701 |
| 3.4.23.46 | 754489 |
A comparative molecular dynamics study on BACE1 and BACE2 flap flexibility |
J. Recept. Signal Transduct. Res. |
36 |
505-514 |
2016 |
Homo sapiens |
26804314 |
| 3.4.23.46 | 753620 |
Application of BACE1 immobilized enzyme reactor for the characterization of multifunctional alkaloids from Corydalis cava (Fumariaceae) as Alzheimers disease targets |
Fitoterapia |
109 |
241-247 |
2016 |
Homo sapiens |
26779945 |
| 3.4.23.46 | 754198 |
Computational analysis of BACE1-ligand complex crystal structures and linear discriminant analysis for identification of BACE1 inhibitors with anti P-glycoprotein binding property |
J. Biomol. Struct. Dyn. |
36 |
262-276 |
2018 |
Homo sapiens |
28081663 |
| 3.4.23.46 | 753331 |
Computational insights into beta-site amyloid precursor protein enzyme 1 (BACE1) inhibition by tanshinones and salvianolic acids from Salvia miltiorrhiza via molecular docking simulations |
Comput. Biol. Chem. |
74 |
273-285 |
2018 |
Homo sapiens |
29679864 |
| 3.4.23.46 | 752962 |
Design and synthesis of bicyclic acetals as beta secretase (BACE1) inhibitors |
Bioorg. Med. Chem. |
25 |
5077-5083 |
2017 |
Homo sapiens |
28359674 |
| 3.4.23.46 | 753256 |
Design of potent and highly selective inhibitors for human beta-secretase 2 (memapsin 1), a target for type 2 diabetes |
Chem. Sci. |
7 |
3117-3122 |
2016 |
Homo sapiens |
27347366 |
| 3.4.23.46 | 753008 |
Design, synthesis, X-ray studies, and biological evaluation of novel BACE1 inhibitors with bicyclic isoxazoline carboxamides as the P3 ligand |
Bioorg. Med. Chem. Lett. |
28 |
2605-2610 |
2018 |
Homo sapiens |
29970308 |
| 3.4.23.46 | 753490 |
Discovery of imidazopyridines containing isoindoline-1,3-dione framework as a new class of BACE1 inhibitors Design, synthesis and SAR analysis |
Eur. J. Med. Chem. |
138 |
729-737 |
2017 |
Homo sapiens |
28728105 |
| 3.4.23.46 | 754384 |
Discovery of S3-truncated, C-6 heteroaryl substituted aminothiazine beta-site APP cleaving enzyme-1 (BACE1) inhibitors |
J. Med. Chem. |
59 |
8593-8600 |
2016 |
Mus musculus |
27559936 |
