4.3.1.30 | dTDP-4-amino-4,6-dideoxy-alpha-D-glucopyranose + S-adenosyl-L-methionine + reduced acceptor = dTDP-3-dehydro-4,6-dideoxy-alpha-D-glucopyranose + NH3 + L-methionine + 5'-deoxyadenosine + acceptor |
DesII must be in the correct protonation state to form the initial alpha-hydroxyalkyl radical and that it is subsequently deprotonated either before or concerted with its oxidation |
730823 |