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EC Number Reaction Commentary Reference
Show all pathways known for 2.7.1.6Display the word mapDisplay the reaction diagram Show all sequences 2.7.1.6ATP + alpha-D-galactose = ADP + alpha-D-galactose 1-phosphate mechanism of D-galactose and nucleotide binding 662617
Show all pathways known for 2.7.1.6Display the word mapDisplay the reaction diagram Show all sequences 2.7.1.6ATP + alpha-D-galactose = ADP + alpha-D-galactose 1-phosphate mechanism of the reaction is sequential in both directions. Residue Asp183 acts as a catalytic base that deprotonates the C1 hydroxyl group of galactose. The pH-kcat profile of the synthesis of galactose 1-phosphate has a pKa of 6.9 likely due to Asp183. The pH-kcat/KGal profile of the reverse reaction lacks a key pKa required for a direct proton transfer mechanism. Arg36 may lower the pKa of the C1 hydroxyl to facilitate deprotonation 738227
Show all pathways known for 2.7.1.6Display the word mapDisplay the reaction diagram Show all sequences 2.7.1.6ATP + alpha-D-galactose = ADP + alpha-D-galactose 1-phosphate the most likely kinetic mechanism is an ordered ternary complex in which ATP is the first substrate to bind 641728
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