EC Number   |
Posttranslational Modification |
Reference |
|---|
   5.6.2.2 | acetylation |
acetylation of specific sites involved in the allosteric regulation of the enzyme provide a mechanism for modulation of its catalytic activity |
752248 |
| 5.6.2.2 | more |
the enzyme contains two putative sumoylation motifs, both at corresponding sites in the C-terminal region. Sumoylation of the enzyme is not required for centromere-specific cleavage activity, in contrast to other species |
-, 716381 |
| 5.6.2.2 | phosphoprotein |
- |
752248 |
| 5.6.2.2 | phosphoprotein |
both human isozymes topo IIalpha and beta are phosphorylated. Phosphorylation sites of topo IIbeta are Tyr656, Ser1395, Thr1426 and Ser1545 |
716887 |
| 5.6.2.2 | phosphoprotein |
casein kinase II phosphorylates the C-terminal residues Ser-1363 and Ser-1364 |
751126 |
| 5.6.2.2 | phosphoprotein |
phosphorylation at S1106, S1247, S1354, or S1393 is required for activity, but not essential |
662813 |
| 5.6.2.2 | phosphoprotein |
phosphorylation at Ser1524 and stabilization of topoisomerase IIalpha protein by p38gamma mitogen-activated protein kinase in vivo and in vitro, in vitro kinase assay using recombinant TopoIIalpha and recombinant His-tagged p38gamma |
727888 |
| 5.6.2.2 | sumoylation |
- |
691609 |
| 5.6.2.2 | sumoylation |
RanBP2 sumoylates Topo IIalpha in mitosis, this modification is required for its proper localization to inner centromeres |
691662 |
