Any feedback?
Please rate this page
(search_result.php)
(0/150)

BRENDA support

Refine search

Search Application

show results
Don't show organism specific information (fast!)
Search organism in taxonomic tree (slow, choose "exact" as search mode, e.g. "mammalia" for rat,human,monkey,...)
(Not possible to combine with the first option)
Refine your search

Search term:

Results 1 - 1 of 1
download as CSV
download all results as CSV
EC Number Application Commentary Reference
Show all pathways known for 6.3.4.21Display the word mapDisplay the reaction diagram Show all sequences 6.3.4.21medicine NAPRT is amplified and overexpressed in a subset of common types of cancer, including ovarian cancer, where NAPRT expression correlates with a BRCAness gene expression signature. Both NAPRT and nicotinamide phosphoribosyltransferase NAMPT increase intracellular NAD+ levels. NAPRT silencing reduces energy status, protein synthesis, and cell size in ovarian and pancreatic cancer cells. NAPRT silencing sensitizes cells to NAMPT inhibitors both in vitro and in vivo. Reducing NAPRT levels in a BRCA2-deficient cancer cell line exacerbates DNA damage in response to chemotherapeutics 744621
Results 1 - 1 of 1
download as CSV
download all results as CSV