EC Number   |
Application |
Reference |
|---|
    4.2.1.22 | analysis |
development of 7-azido-4-carbamoylmethylcoumarin as a modified fluorogenic probe for H2S detection with improved solubility in aqueous solutions |
747267 |
| 4.2.1.22 | analysis |
development of a LC-MS/MS and HPLC methods to simultaneously measure formation of thioethers and hydrogen sulfide from mixtures of cystathionine beta-synthase substrates |
746768 |
| 4.2.1.22 | analysis |
usefulness of the CBS domains as predictors of osmoregulatory activity |
680504 |
| 4.2.1.22 | diagnostics |
evaluation of plasma cystathionine beta-synthase activity in cystathionine beta-synthase-deficient patients for utilization of the assay in diagnosis and study of cystathionine beta-synthase deficiency |
715809 |
| 4.2.1.22 | diagnostics |
the mutations present in each country differ from each other depending on the demographic profile. Therefore, specific mutations scanning must be performed in each population for diagnosis and prognosis purposes |
666370 |
| 4.2.1.22 | medicine |
a deficiency of cystathionine beta-synthase causes various neurodevelopmental defects which result in complex neuropathological features associated with abnormal homocysteine metabolism, and also suggest that radial glia/astrocyte lineage cells might be a new therapeutic target for preventing and treating them |
664879 |
| 4.2.1.22 | medicine |
breast cancer patient-derived tissues and breast cancer cells exhibit significantly increased levels of CBS when compared with their normal counterparts, associated with increased levels of H2S and cystathionine. Silencing of CBS in breast cancer cells causes a significant decrease in the levels of H2S and cystathionine but does not affect the growth of these cells per se, in in vitro cultures. CBS-silenced cells exhibit significantly reduced growth in the presence of activated macrophages and in xenograft models, associated with an increase in the steady state levels of reactive aldehyde-derived protein adducts |
747830 |
| 4.2.1.22 | medicine |
CBS-deficient patients have significantly elevated plasma levels of prothrombotic N-homocysteine-fibrinogen |
697850 |
| 4.2.1.22 | medicine |
inherited deficiency leads to homocystinura, a disease of sulfur metabolism |
650981 |
| 4.2.1.22 | medicine |
inherited deficiency leads to homocystinura, a disease of sulfur metabolism characterized by increased levels of homocysteine and methionine and decreased levels of cysteine |
650405 |
