EC Number   |
Natural Substrates |
|---|
    3.1.1.2 | more |
the enzyme is one of the HDL-associated antioxidant proteins, overview |
| 3.1.1.2 | more |
paraoxonase-1 is an enzyme with three activities which are inversely related to cardiovascular diseases, paraoxonase and arylesterase activities are involved in coronary artery disease, overview |
| 3.1.1.2 | more |
polymorphisms allele frequency in relation to exposure of individuals to organophosphates, overview |
| 3.1.1.2 | more |
PON1 hydrolyses esters, including organophosphates and lactones, and exhibits anti-atherogenic properties, the enzyme is associated to high-density-lipoprotein, bound together with the human phosphate binding protein |
| 3.1.1.2 | more |
the enzyme is important in the mechanism of organophosphorous toxicity |
| 3.1.1.2 | more |
PON1 hydrolyzes organophosphates, such as paraoxon, aromatic esters, for instance, phenyl acetate, and also lipid peroxidation products, and reduces the accumulation of them, PON1 prevents the acceleration of atherosclerosis, exhibits antioxidant ability, and assumes an antiatherogenic property. Negative correlation between the activity of PON1 and the level of lipid hydroperoxides in the rheumatoid arthritis patient group, overview |
| 3.1.1.2 | more |
PON1 is not able to prevent macrophage oxidative stress, however, is able to retard macrophage-induced low-density lipoprotein oxidation |
| 3.1.1.2 | more |
PON1 plays a key role in the protection of low density lipoproteins and high density lipoproteins from oxidation by hydrolyzing activated phospholipids and lipid peroxide products |
| 3.1.1.2 | more |
the active site of the enzyme is characterized by two distinct binding regions, the hydrophobic binding site for arylesters/lactones and the paraoxon binding site for phosphotriesters |
| 3.1.1.2 | more |
the enzyme is located on high-density lipoprotein and prevents low-density-lipoprotein and high-density-lipoprotein oxidation both in vivo and in vitro through hydrolysis of lipid peroxides, the risk of ischemic stroke is related to the genotype of PON1 192RQ polymorphisms, overview |
