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1-naphthyl acetate + H2O
1-naphthol + acetate
1-naphthyl butyrate + H2O
1-naphthol + butyrate
-
-
-
-
?
1-phenylvinyl acetate + H2O
1-phenylethylenol + acetate
-
-
-
?
2,2,2-trifluoroethyl acetate + H2O
2,2,2-trifluoroethanol + acetate
-
-
-
?
2,2-difluoroethyl acetate + H2O
2,2-difluoroethanol + acetate
-
-
-
?
2,3-difluorophenyl acetate + H2O
2,3-difluorophenol + acetate
-
-
-
?
2,4-difluorophenyl acetate + H2O
2,4-difluorophenol + acetate
-
-
-
?
2,6-difluorophenyl acetate + H2O
2,6-difluorophenol + acetate
-
-
-
?
2-carboxythiophenyl acetate + H2O
2-carboxythiophenol + acetate
-
-
-
?
2-fluoroethyl acetate + H2O
2-fluoroethanol + acetate
-
-
-
?
2-fluorophenyl acetate + H2O
2-fluorophenol + acetate
-
-
-
?
2-methoxythiophenyl acetate + H2O
2-methoxythiophenol + acetate
-
-
-
?
2-naphthyl acetate + H2O
2-naphthol + acetate
2-naphthyl butanoate + H2O
2-naphthol + butanoate
-
-
-
?
2-naphthyl butyrate + H2O
2-naphthol + butyrate
-
-
-
-
?
2-napthyl acetate + H2O
2-naphthol + acetate
-
-
-
?
2-nitrophenyl acetate + H2O
2-nitrophenol + acetate
3,4-dimethyl phenyl acetate + H2O
3,4-dimethylphenol + acetate
-
-
-
?
3-acetoxypyridine + H2O
?
-
-
?
3-cyanophenyl acetate + H2O
3-cyanophenol + acetate
-
-
-
?
3-fluorophenyl acetate + H2O
3-fluorophenol + acetate
-
-
-
?
3-naphthyl acetate + H2O
3-naphthol + acetate
-
-
-
?
3-naphthyl butanoate + H2O
3-naphthol + butanoate
-
-
-
?
3-nitrophenyl acetate + H2O
3-nitrophenol + acetate
-
-
-
?
4-(chloromethyl)phenyl acetate + H2O
4-chloromethyl phenol + acetate
-
-
-
?
4-acetoxyacetophenone + H2O
4-hydroxyacetophenone + acetate
-
-
-
?
4-acetoxybenzaldehyde + H2O
4-hydroxybenzaldehyde + acetate
-
-
-
?
4-acetoxybenzaldehyde + H2O
?
4-carboxyphenyl acetate + H2O
4-carboxyphenol + acetate
-
-
-
?
4-chlorophenyl acetate + H2O
4-chlorophenol + acetate
-
-
-
?
4-cyanophenyl acetate + H2O
4-cyanophenol + acetate
-
-
-
?
4-diethyl phosphate methyl benzoate + H2O
?
-
-
-
?
4-methoxy phenyl acetate + H2O
4-methoxy phenol + acetate
-
-
-
?
4-methylphenyl acetate + H2O
4-methylphenol + acetate
-
-
-
?
4-nitrophenyl acetate + H2O
4-nitrophenol + acetate
4-nitrophenyl butanoate + H2O
4-nitrophenol + butanoate
4-nitrophenyl butyrate + H2O
4-nitrophenol + butyrate
4-nitrophenyl caprate + H2O
4-nitrophenol + caprate
-
-
-
?
4-nitrophenyl caproate + H2O
4-nitrophenol + caproate
4-nitrophenyl caprylate + H2O
4-nitrophenol + caprylate
4-nitrophenyl decanoate + H2O
4-nitrophenol + decanoate
4-nitrophenyl diethylphosphate + H2O
diethylphosphate + 4-nitrophenol
4-nitrophenyl hexanoate + H2O
4-nitrophenol + hexanoate
4-nitrophenyl laurate + H2O
4-nitrophenol + laurate
4-nitrophenyl myristate + H2O
4-nitrophenol + myristate
about 10% of the activity with 4-nitrophenyl acetate
-
-
?
4-nitrophenyl octanoate + H2O
4-nitrophenol + octanoate
-
-
?
4-nitrophenyl palmitate + H2O
4-nitrophenol + palmitate
4-nitrophenyl pentanoate + H2O
4-nitrophenol + pentanoate
-
-
?
4-nitrophenyl phosphate + H2O
4-nitrophenol + phosphate
4-nitrophenyl propionate + H2O
4-nitrophenol + propionate
4-nitrophenyl valerate + H2O
4-nitrophenol + valerate
-
-
?
7-aminocephalosporanic acid + H2O
?
-
-
-
-
?
9-(2,4-dimethylphenoxycarbonyl)-10-methylacridinium triflate + H2O
2,4-dimethylphenol + 10-methylacridinium trifluoromethanesulfonate
-
-
-
-
?
9-(4-chlorophenoxycarbonyl)-10-methylacridinium triflate + H2O
4-chlorophenol + 10-methylacridinium trifluoromethanesulfonate
-
-
-
-
?
9-(4-chlorophenyloxycarbonyl)-10-methylacridinium triflate + H2O
9-carboxy-10-methylacridinium triflate + 4-chlorophenol
-
-
-
-
?
9-(4-methylphenoxycarbonyl)-10-methylacridinium triflate + H2O
4-methylphenol + 10-methylacridinium trifluoromethanesulfonate
-
-
-
-
?
9-(4-tert-butylphenoxycarbonyl)-10-methylacridinium triflate + H2O
4-tert-butylphenol + 10-methylacridinium trifluoromethanesulfonate
-
-
-
-
?
9-(phenyloxycarbonyl)-10-methylacridinium triflate + H2O
phenol + 10-methylacridinium trifluoromethanesulfonate
-
-
-
-
?
acetylcholine chloride + H2O
?
-
-
-
-
?
alpha-naphthyl acetate + H2O
alpha-naphthol + acetate
benzyl acetate + H2O
benzyl alcohol + acetate
-
-
-
?
beta-naphthyl acetate + H2O
beta-naphthol + acetate
-
-
-
-
?
bromoxynil octanoate + H2O
?
butyl acetate + H2O
butanol + acetate
-
-
-
?
butyrylcholine iodide + H2O
?
-
-
-
-
?
cephalosporin C + H2O
?
-
-
-
-
?
ethyl acetate + H2O
ethanol + acetate
-
-
-
?
ethyl hexanoate + H2O
ethanol + hexanoate
-
-
?
isopropyl acetate + H2O
isobutanol + acetate
-
-
-
?
ketoprofen ethyl ester + H2O
?
-
-
-
-
?
methyl 4-(acetyloxy)benzoate + H2O
methyl 4-hydroxybenzoate + acetate
-
-
-
?
mipafox + H2O
?
-
-
-
-
?
naphthalen-2-yl acetate + H2O
2-naphthol + acetate
-
-
-
?
p-nitrophenyl butyrate + H2O
p-nitrophenol + butanoate
-
-
-
-
?
p-nitrophenyl propionate + H2O
p-nitrophenol + propanoate
-
-
-
-
?
phenyl acetate + H2O
phenol + acetate
phenyl valerate + H2O
phenol + valerate
-
-
-
-
?
phenylacetate + H2O
phenol + acetate
phenylthioacetate + H2O
thiophenol + acetate
propioncholine iodide + H2O
?
-
-
-
-
?
propyl acetate + H2O
propanol + acetate
-
-
-
?
S-(4-carboxyphenyl)-thioacetate + H2O
4-carboxythiophenol + acetate
-
-
-
?
S-methyl thiobutanoate + H2O
methanol + thiobutanoate
thiophenyl acetate + H2O
?
thiophenyl acetate + H2O
phenol + thioacetate
-
-
-
-
?
thiophenyl acetate + H2O
thiophenol + acetate
-
-
-
?
tributyrin + H2O
dibutyrin + butyrate
-
-
-
?
[(3-[(3-hydroxypropoxy)carbonyl]-5-[[3-([4-[(3-hydroxypropoxy)carbonyl]benzoyl]oxy)propoxy]carbonyl]phenyl)-lambda4-sulfanetriyl]tris(oxidanide) + H2O
terephthalic acid + 5-sulfoisophthalic acid + 1,3-propanediol
-
-
-
?
additional information
?
-
1-naphthyl acetate + H2O

1-naphthol + acetate
-
-
-
-
?
1-naphthyl acetate + H2O
1-naphthol + acetate
-
-
-
-
?
1-naphthyl acetate + H2O
1-naphthol + acetate
-
-
-
-
?
1-naphthyl acetate + H2O
1-naphthol + acetate
-
-
-
-
?
1-naphthyl acetate + H2O
1-naphthol + acetate
-
-
-
-
?
1-naphthyl acetate + H2O
1-naphthol + acetate
-
0.1% of the activity with phenyl acetate, A-type enzyme. 0.25% of the activity with phenyl acetate, B-type enzyme
-
-
?
1-naphthyl acetate + H2O
1-naphthol + acetate
-
0.1% of the activity with phenyl acetate
-
-
?
1-naphthyl acetate + H2O
1-naphthol + acetate
-
-
-
-
?
1-naphthyl acetate + H2O
1-naphthol + acetate
-
-
-
-
?
1-naphthyl acetate + H2O
1-naphthol + acetate
15.4% activity compared to 4-nitrophenyl acetate
-
-
?
2-naphthyl acetate + H2O

2-naphthol + acetate
-
-
-
?
2-naphthyl acetate + H2O
2-naphthol + acetate
-
-
-
-
?
2-naphthyl acetate + H2O
2-naphthol + acetate
-
-
-
?
2-naphthyl acetate + H2O
2-naphthol + acetate
-
-
-
-
?
2-naphthyl acetate + H2O
2-naphthol + acetate
-
-
-
?
2-naphthyl acetate + H2O
2-naphthol + acetate
-
-
-
-
?
2-naphthyl acetate + H2O
2-naphthol + acetate
-
-
-
?
2-naphthyl acetate + H2O
2-naphthol + acetate
-
-
-
-
?
2-naphthyl acetate + H2O
2-naphthol + acetate
-
-
-
?
2-naphthyl acetate + H2O
2-naphthol + acetate
-
5.5% of the activity with phenyl acetate, A-type enzyme. 7% of the activity with phenyl acetate, B-type enzyme
-
-
?
2-naphthyl acetate + H2O
2-naphthol + acetate
-
-
-
-
?
2-naphthyl acetate + H2O
2-naphthol + acetate
-
-
-
?
2-naphthyl acetate + H2O
2-naphthol + acetate
-
13.5% of the activity with phenyl acetate
-
-
?
2-naphthyl acetate + H2O
2-naphthol + acetate
-
-
-
-
?
2-nitrophenyl acetate + H2O

2-nitrophenol + acetate
-
-
-
-
?
2-nitrophenyl acetate + H2O
2-nitrophenol + acetate
-
2.1% of the activity with phenyl acetate, A-type enzyme. 2% of the activity with phenyl acetate, B-type enzyme
-
-
?
2-nitrophenyl acetate + H2O
2-nitrophenol + acetate
-
29% of the activity with phenyl acetate
-
-
?
4-acetoxybenzaldehyde + H2O

?
-
-
-
?
4-acetoxybenzaldehyde + H2O
?
-
-
?
4-nitrophenyl acetate + H2O

4-nitrophenol + acetate
-
-
-
?
4-nitrophenyl acetate + H2O
4-nitrophenol + acetate
-
-
-
?
4-nitrophenyl acetate + H2O
4-nitrophenol + acetate
-
inversely proportional relationship between the maximum specific growth rates of rhizobia strains and the activity of the entire alpha-esterase and beta-esterase pattern
-
-
?
4-nitrophenyl acetate + H2O
4-nitrophenol + acetate
-
inversely proportional relationship between the maximum specific growth rates of rhizobia strains and the activity of the entire alpha-esterase and beta-esterase pattern
-
-
?
4-nitrophenyl acetate + H2O
4-nitrophenol + acetate
-
-
-
?, ir
4-nitrophenyl acetate + H2O
4-nitrophenol + acetate
-
-
-
-
?
4-nitrophenyl acetate + H2O
4-nitrophenol + acetate
-
-
-
-
?
4-nitrophenyl acetate + H2O
4-nitrophenol + acetate
-
-
-
-
?
4-nitrophenyl acetate + H2O
4-nitrophenol + acetate
-
-
-
?
4-nitrophenyl acetate + H2O
4-nitrophenol + acetate
-
-
-
-
?
4-nitrophenyl acetate + H2O
4-nitrophenol + acetate
-
-
-
?
4-nitrophenyl acetate + H2O
4-nitrophenol + acetate
-
-
-
-
?
4-nitrophenyl acetate + H2O
4-nitrophenol + acetate
-
-
-
?
4-nitrophenyl acetate + H2O
4-nitrophenol + acetate
-
-
-
-
?
4-nitrophenyl acetate + H2O
4-nitrophenol + acetate
-
2.5% of the activity with phenyl acetate, A-type enzyme. 3.5% of the activity with phenyl acetate, B-type enzyme
-
-
?
4-nitrophenyl acetate + H2O
4-nitrophenol + acetate
activity is 2.6fold higher than that with PON1 (P27169 (UniProt))
-
-
?
4-nitrophenyl acetate + H2O
4-nitrophenol + acetate
activity is about 40% of the activity with PON3 (Q15166 (UniProt))
-
-
?
4-nitrophenyl acetate + H2O
4-nitrophenol + acetate
activity is about 5% of that with PON1 (P27169 (UniProt))
-
-
?
4-nitrophenyl acetate + H2O
4-nitrophenol + acetate
-
-
?
4-nitrophenyl acetate + H2O
4-nitrophenol + acetate
-
-
-
?
4-nitrophenyl acetate + H2O
4-nitrophenol + acetate
-
-
-
?
4-nitrophenyl acetate + H2O
4-nitrophenol + acetate
-
-
?
4-nitrophenyl acetate + H2O
4-nitrophenol + acetate
-
-
?
4-nitrophenyl acetate + H2O
4-nitrophenol + acetate
-
-
-
-
?
4-nitrophenyl acetate + H2O
4-nitrophenol + acetate
-
inversely proportional relationship between the maximum specific growth rates of rhizobia strains and the activity of the entire alpha-esterase and beta-esterase pattern
-
-
?
4-nitrophenyl acetate + H2O
4-nitrophenol + acetate
-
-
-
-
?
4-nitrophenyl acetate + H2O
4-nitrophenol + acetate
-
31% of the activity with phenyl acetate
-
-
?
4-nitrophenyl acetate + H2O
4-nitrophenol + acetate
-
inversely proportional relationship between the maximum specific growth rates of rhizobia strains and the activity of the entire alpha-esterase and beta-esterase pattern
-
-
?
4-nitrophenyl acetate + H2O
4-nitrophenol + acetate
-
inversely proportional relationship between the maximum specific growth rates of rhizobia strains and the activity of the entire alpha-esterase and beta-esterase pattern
-
-
?
4-nitrophenyl acetate + H2O
4-nitrophenol + acetate
-
inversely proportional relationship between the maximum specific growth rates of rhizobia strains and the activity of the entire alpha-esterase and beta-esterase pattern
-
-
?
4-nitrophenyl acetate + H2O
4-nitrophenol + acetate
-
shows maximum activity (100%) against p-nitrophenyl acetate
-
-
?
4-nitrophenyl acetate + H2O
4-nitrophenol + acetate
-
-
-
-
?
4-nitrophenyl acetate + H2O
4-nitrophenol + acetate
-
-
-
?
4-nitrophenyl acetate + H2O
4-nitrophenol + acetate
-
-
-
?
4-nitrophenyl acetate + H2O
4-nitrophenol + acetate
-
-
-
?
4-nitrophenyl acetate + H2O
4-nitrophenol + acetate
-
-
-
?
4-nitrophenyl acetate + H2O
4-nitrophenol + acetate
-
-
-
?
4-nitrophenyl acetate + H2O
4-nitrophenol + acetate
highest catalytic efficiency (100% activity)
-
-
?
4-nitrophenyl acetate + H2O
4-nitrophenol + acetate
-
-
-
?
4-nitrophenyl butanoate + H2O

4-nitrophenol + butanoate
-
-
-
?
4-nitrophenyl butanoate + H2O
4-nitrophenol + butanoate
-
-
-
?
4-nitrophenyl butanoate + H2O
4-nitrophenol + butanoate
about 15% of the activity with 4-nitrophenyl acetate
-
-
?
4-nitrophenyl butanoate + H2O
4-nitrophenol + butanoate
about 15% of the activity with 4-nitrophenyl acetate
-
-
?
4-nitrophenyl butyrate + H2O

4-nitrophenol + butyrate
-
highest specific activity
-
-
?
4-nitrophenyl butyrate + H2O
4-nitrophenol + butyrate
-
best substrate
-
-
?
4-nitrophenyl butyrate + H2O
4-nitrophenol + butyrate
-
best substrate
-
-
?
4-nitrophenyl butyrate + H2O
4-nitrophenol + butyrate
activity is similar to that with PON1 (P27169 (UniProt))
-
-
?
4-nitrophenyl butyrate + H2O
4-nitrophenol + butyrate
-
-
?
4-nitrophenyl butyrate + H2O
4-nitrophenol + butyrate
-
-
?
4-nitrophenyl butyrate + H2O
4-nitrophenol + butyrate
-
-
-
?
4-nitrophenyl butyrate + H2O
4-nitrophenol + butyrate
-
-
-
?
4-nitrophenyl butyrate + H2O
4-nitrophenol + butyrate
-
-
-
?
4-nitrophenyl butyrate + H2O
4-nitrophenol + butyrate
-
-
-
-
?
4-nitrophenyl butyrate + H2O
4-nitrophenol + butyrate
19.7% activity compared to 4-nitrophenyl acetate
-
-
?
4-nitrophenyl caproate + H2O

4-nitrophenol + caproate
-
-
?
4-nitrophenyl caproate + H2O
4-nitrophenol + caproate
-
-
-
?
4-nitrophenyl caproate + H2O
4-nitrophenol + caproate
-
-
-
?
4-nitrophenyl caproate + H2O
4-nitrophenol + caproate
4.1% activity compared to 4-nitrophenyl acetate
-
-
?
4-nitrophenyl caprylate + H2O

4-nitrophenol + caprylate
-
10% activity compared to 4-nitrophenyl butyrate
-
-
?
4-nitrophenyl caprylate + H2O
4-nitrophenol + caprylate
-
-
-
-
?
4-nitrophenyl caprylate + H2O
4-nitrophenol + caprylate
about 10% of the activity with 4-nitrophenyl acetate
-
-
?
4-nitrophenyl caprylate + H2O
4-nitrophenol + caprylate
about 10% of the activity with 4-nitrophenyl acetate
-
-
?
4-nitrophenyl caprylate + H2O
4-nitrophenol + caprylate
-
-
?
4-nitrophenyl caprylate + H2O
4-nitrophenol + caprylate
-
-
-
?
4-nitrophenyl decanoate + H2O

4-nitrophenol + decanoate
-
-
?
4-nitrophenyl decanoate + H2O
4-nitrophenol + decanoate
-
low activity
-
-
?
4-nitrophenyl diethylphosphate + H2O

diethylphosphate + 4-nitrophenol
-
-
-
?
4-nitrophenyl diethylphosphate + H2O
diethylphosphate + 4-nitrophenol
-
-
-
?
4-nitrophenyl hexanoate + H2O

4-nitrophenol + hexanoate
-
-
-
-
?
4-nitrophenyl hexanoate + H2O
4-nitrophenol + hexanoate
-
-
?
4-nitrophenyl laurate + H2O

4-nitrophenol + laurate
-
-
-
-
?
4-nitrophenyl laurate + H2O
4-nitrophenol + laurate
about 10% of the activity with 4-nitrophenyl acetate
-
-
?
4-nitrophenyl laurate + H2O
4-nitrophenol + laurate
about 10% of the activity with 4-nitrophenyl acetate
-
-
?
4-nitrophenyl laurate + H2O
4-nitrophenol + laurate
-
-
-
?
4-nitrophenyl palmitate + H2O

4-nitrophenol + palmitate
about 5% of the activity with 4-nitrophenyl acetate
-
-
?
4-nitrophenyl palmitate + H2O
4-nitrophenol + palmitate
about 5% of the activity with 4-nitrophenyl acetate
-
-
?
4-nitrophenyl palmitate + H2O
4-nitrophenol + palmitate
-
-
-
?
4-nitrophenyl phosphate + H2O

4-nitrophenol + phosphate
-
-
-
?
4-nitrophenyl phosphate + H2O
4-nitrophenol + phosphate
-
-
-
?
4-nitrophenyl propionate + H2O

4-nitrophenol + propionate
activity is 1.5fold higher than that with PON1 (P27169 (UniProt))
-
-
?
4-nitrophenyl propionate + H2O
4-nitrophenol + propionate
activity is 8.7fold higher than that with PON1 (P27169 (UniProt))
-
-
?
4-nitrophenyl propionate + H2O
4-nitrophenol + propionate
activity is about 10% of the activity with PON3 (Q15166 (UniProt))
-
-
?
4-nitrophenyl propionate + H2O
4-nitrophenol + propionate
activity is about 65% of the activity with PON3 (Q15166 (UniProt))
-
-
?
4-nitrophenyl propionate + H2O
4-nitrophenol + propionate
activity is about 7% of that with PON1 (P27169 (UniProt))
-
-
?
4-nitrophenyl propionate + H2O
4-nitrophenol + propionate
-
-
?
4-nitrophenyl propionate + H2O
4-nitrophenol + propionate
-
-
?
4-nitrophenyl propionate + H2O
4-nitrophenol + propionate
-
-
?
alpha-naphthyl acetate + H2O

alpha-naphthol + acetate
-
-
-
?
alpha-naphthyl acetate + H2O
alpha-naphthol + acetate
-
-
-
?
alpha-naphthyl acetate + H2O
alpha-naphthol + acetate
-
-
-
-
?
alpha-naphthyl acetate + H2O
alpha-naphthol + acetate
-
-
-
?
alpha-naphthyl acetate + H2O
alpha-naphthol + acetate
-
-
-
?
alpha-naphthyl acetate + H2O
alpha-naphthol + acetate
-
-
-
-
?
alpha-naphthyl acetate + H2O
alpha-naphthol + acetate
-
-
-
?
binapacryl + H2O

?
-
-
-
?
binapacryl + H2O
?
-
-
-
?
binapacryl + H2O
?
-
-
-
?
bromoxynil octanoate + H2O

?
-
-
-
?
bromoxynil octanoate + H2O
?
-
-
-
?
bromoxynil octanoate + H2O
?
-
-
-
?
diclofop methyl + H2O

?
-
-
-
?
diclofop methyl + H2O
?
-
-
-
?
diclofop methyl + H2O
?
-
-
-
?
phenyl acetate + H2O

?
-
-
-
-
?
phenyl acetate + H2O
?
-
-
-
-
?
phenyl acetate + H2O
?
-
-
-
-
?
phenyl acetate + H2O
?
-
-
-
-
?
phenyl acetate + H2O
?
-
-
-
-
?
phenyl acetate + H2O
?
-
-
-
-
?
phenyl acetate + H2O
?
-
-
-
-
?
phenyl acetate + H2O

phenol + acetate
-
-
-
-
?
phenyl acetate + H2O
phenol + acetate
-
-
-
-
?
phenyl acetate + H2O
phenol + acetate
-
-
-
-
ir
phenyl acetate + H2O
phenol + acetate
-
-
-
-
?
phenyl acetate + H2O
phenol + acetate
-
-
-
-
?
phenyl acetate + H2O
phenol + acetate
-
-
-
?
phenyl acetate + H2O
phenol + acetate
-
-
-
-
?
phenyl acetate + H2O
phenol + acetate
-
-
-
?
phenyl acetate + H2O
phenol + acetate
-
-
-
-
?
phenyl acetate + H2O
phenol + acetate
-
-
-
?
phenyl acetate + H2O
phenol + acetate
-
-
-
-
?
phenyl acetate + H2O
phenol + acetate
-
-
-
?
phenyl acetate + H2O
phenol + acetate
-
-
652704, 665028, 692695, 693321, 702421, 703470, 707155, 707214, 708095, 709261, 709755, 714112, 714759, 714893, 714895, 715735, 715738, 729339, 749628, 749762, 749840, 750340, 750345, 750428, 750482, 750483, 750484, 750511, 750758, 752150, 752173 -
-
?
phenyl acetate + H2O
phenol + acetate
-
-
-
?
phenyl acetate + H2O
phenol + acetate
-
-
-
-
?
phenyl acetate + H2O
phenol + acetate
-
-
-
?
phenyl acetate + H2O
phenol + acetate
-
-
-
-
?
phenyl acetate + H2O
phenol + acetate
-
-
-
?
phenyl acetate + H2O
phenol + acetate
-
-
-
-
?
phenyl acetate + H2O
phenol + acetate
-
-
-
?
phenyl acetate + H2O
phenol + acetate
-
-
-
-
?
phenyl acetate + H2O
phenol + acetate
-
-
-
?
phenyl acetate + H2O
phenol + acetate
-
-
-
-
?
phenyl acetate + H2O
phenol + acetate
-
-
-
?
phenyl acetate + H2O
phenol + acetate
-
-
-
-
?
phenyl acetate + H2O
phenol + acetate
-
-
-
?
phenyl acetate + H2O
phenol + acetate
-
-
-
-
?
phenyl acetate + H2O
phenol + acetate
-
-
-
?
phenyl acetate + H2O
phenol + acetate
-
-
-
-
?
phenyl acetate + H2O
phenol + acetate
-
-
-
?
phenyl acetate + H2O
phenol + acetate
-
-
-
-
?
phenyl acetate + H2O
phenol + acetate
-
-
-
?
phenyl acetate + H2O
phenol + acetate
-
-
-
-
?
phenyl acetate + H2O
phenol + acetate
-
-
-
?
phenyl acetate + H2O
phenol + acetate
-
-
-
-
?
phenyl acetate + H2O
phenol + acetate
-
-
-
?
phenyl acetate + H2O
phenol + acetate
-
-
-
?
phenyl acetate + H2O
phenol + acetate
-
-
-
-
?
phenyl acetate + H2O
phenol + acetate
activity is less than 1% of that with PON1 (P27169 (UniProt))
-
-
?
phenyl acetate + H2O
phenol + acetate
activity is more than 100fold higher than with PON2 (Q15165 (UniProt)) and PON3 (Q15166 (UniProt))
-
-
?
phenyl acetate + H2O
phenol + acetate
arylesterase activity is independent of the polymorphic form of PON1
-
-
?
phenyl acetate + H2O
phenol + acetate
arylesterase activity of PON1
-
-
?
phenyl acetate + H2O
phenol + acetate
enzyme protein also shows activities of EC 3.1.8.1 and EC 3.1.1.25
-
-
?
phenyl acetate + H2O
phenol + acetate
-
human serum paraoxonase/arylesterase is an esterase with broad substrate specificity. It occurs in two genetically determined allozymic forms, designated types A and B. These allozymes are the products of two allelic genes located at the paraoxonase locus on chromosome 7, which is closely linked to the gene for cystic fibrosis. Paraoxonase activity of the B type isozyme is considerably higher and stimulated more by 1 M NaCl than A-type paraoxonase. The ratio of paraoxonase activity to arylesterase activity of the B-isozyme is about 8, and that of the A isozyme about 1
-
-
?
phenyl acetate + H2O
phenol + acetate
lowest activity with phenyl acetate
-
-
?
phenyl acetate + H2O
phenol + acetate
-
PON1 activity determined towards the synthetic compounds paraoxon and phenyl acetate reflects no association with markers of oxidative stress
-
-
?
phenyl acetate + H2O
phenol + acetate
PON1 activity determined towards the synthetic compounds paraoxon and phenyl acetate reflects no association with markers of oxidative stress
-
-
?
phenyl acetate + H2O
phenol + acetate
shows highest hydrolytic rate towards phenyl acetate
-
-
?
phenyl acetate + H2O
phenol + acetate
-
the enzyme exists in two genetically determined allozymic forms, and these A and B allozymes possess both paraoxonase and arylesterase activities. B-type esterase has relatively higher paraoxonase activity and is stimulated to a greater degree by 1 M NaCl than the A allozyme
-
-
?
phenyl acetate + H2O
phenol + acetate
-
-
?
phenyl acetate + H2O
phenol + acetate
best substrate
-
?
phenyl acetate + H2O
phenol + acetate
best substrate
-
?
phenyl acetate + H2O
phenol + acetate
-
-
-
?
phenyl acetate + H2O
phenol + acetate
-
-
-
-
?
phenyl acetate + H2O
phenol + acetate
-
-
-
?
phenyl acetate + H2O
phenol + acetate
-
-
-
-
?
phenyl acetate + H2O
phenol + acetate
-
-
-
?
phenyl acetate + H2O
phenol + acetate
-
-
-
-
?
phenyl acetate + H2O
phenol + acetate
-
-
-
?
phenyl acetate + H2O
phenol + acetate
-
-
-
?
phenyl acetate + H2O
phenol + acetate
-
-
-
?
phenyl acetate + H2O
phenol + acetate
-
-
-
?
phenyl acetate + H2O
phenol + acetate
-
-
-
?
phenyl acetate + H2O
phenol + acetate
-
-
-
-
?
phenyl acetate + H2O
phenol + acetate
166% activity compared to 4-nitrophenyl acetate
-
-
?
phenylacetate + H2O

phenol + acetate
-
-
-
-
?
phenylacetate + H2O
phenol + acetate
-
-
-
?
phenylacetate + H2O
phenol + acetate
-
-
-
-
?
phenylacetate + H2O
phenol + acetate
-
-
-
?
phenylacetate + H2O
phenol + acetate
-
-
-
-
?
phenylthioacetate + H2O

thiophenol + acetate
-
-
?
phenylthioacetate + H2O
thiophenol + acetate
-
-
?
phenylthioacetate + H2O
thiophenol + acetate
-
-
?
S-methyl thiobutanoate + H2O

methanol + thiobutanoate
-
-
-
-
?
S-methyl thiobutanoate + H2O
methanol + thiobutanoate
-
-
-
?
thiophenyl acetate + H2O

?
-
27% of the activity with phenyl acetate, A-type enzyme. 34% of the activity with phenyl acetate, B-type enzyme
-
-
?
thiophenyl acetate + H2O
?
-
30.5% of the activity with phenyl acetate
-
-
?
additional information

?
-
-
no activity with 4-nitrophenyl laurate and 4-nitrophenyl palmitate
-
-
?
additional information
?
-
-
the enzyme is a carboxylesterase and has highest activity with 4-nitrophenyl butyrate, activity decreases with acylglycerols containing longer carbon chains
-
-
?
additional information
?
-
substrate specificity of this arylesterase is higher toward short chain pnitrophenyl esters (C2 to C4) and also toward aromatic esters, such as phenyl acetate. enzyme is a serine esterase, the catalytic triad is composed of residues Ser163, Asp263, and His293 in the active site
-
-
?
additional information
?
-
substrate specificity of this arylesterase is higher toward short chain pnitrophenyl esters (C2 to C4) and also toward aromatic esters, such as phenyl acetate. enzyme is a serine esterase, the catalytic triad is composed of residues Ser163, Asp263, and His293 in the active site
-
-
?
additional information
?
-
-
the enzyme is one of the HDL-associated antioxidant proteins, overview
-
-
?
additional information
?
-
-
paraoxonase-1 is an enzyme with three activities which are inversely related to cardiovascular diseases, paraoxonase and arylesterase activities are involved in coronary artery disease, overview
-
-
?
additional information
?
-
-
polymorphisms allele frequency in relation to exposure of individuals to organophosphates, overview
-
-
?
additional information
?
-
polymorphisms allele frequency in relation to exposure of individuals to organophosphates, overview
-
-
?
additional information
?
-
PON1 hydrolyses esters, including organophosphates and lactones, and exhibits anti-atherogenic properties, the enzyme is associated to high-density-lipoprotein, bound together with the human phosphate binding protein
-
-
?
additional information
?
-
-
PON1 hydrolyses esters, including organophosphates and lactones, and exhibits anti-atherogenic properties, the enzyme is associated to high-density-lipoprotein, bound together with the human phosphate binding protein
-
-
?
additional information
?
-
-
the enzyme is important in the mechanism of organophosphorous toxicity
-
-
?
additional information
?
-
the enzyme is important in the mechanism of organophosphorous toxicity
-
-
?
additional information
?
-
PON1 hydrolyzes organophosphates, such as paraoxon, aromatic esters, for instance, phenyl acetate, and also lipid peroxidation products, and reduces the accumulation of them, PON1 prevents the acceleration of atherosclerosis, exhibits antioxidant ability, and assumes an antiatherogenic property. Negative correlation between the activity of PON1 and the level of lipid hydroperoxides in the rheumatoid arthritis patient group, overview
-
-
?
additional information
?
-
-
PON1 hydrolyzes organophosphates, such as paraoxon, aromatic esters, for instance, phenyl acetate, and also lipid peroxidation products, and reduces the accumulation of them, PON1 prevents the acceleration of atherosclerosis, exhibits antioxidant ability, and assumes an antiatherogenic property. Negative correlation between the activity of PON1 and the level of lipid hydroperoxides in the rheumatoid arthritis patient group, overview
-
-
?
additional information
?
-
PON1 is not able to prevent macrophage oxidative stress, however, is able to retard macrophage-induced low-density lipoprotein oxidation
-
-
?
additional information
?
-
-
PON1 is not able to prevent macrophage oxidative stress, however, is able to retard macrophage-induced low-density lipoprotein oxidation
-
-
?
additional information
?
-
PON1 plays a key role in the protection of low density lipoproteins and high density lipoproteins from oxidation by hydrolyzing activated phospholipids and lipid peroxide products
-
-
?
additional information
?
-
-
PON1 plays a key role in the protection of low density lipoproteins and high density lipoproteins from oxidation by hydrolyzing activated phospholipids and lipid peroxide products
-
-
?
additional information
?
-
the active site of the enzyme is characterized by two distinct binding regions, the hydrophobic binding site for arylesters/lactones and the paraoxon binding site for phosphotriesters
-
-
?
additional information
?
-
-
the active site of the enzyme is characterized by two distinct binding regions, the hydrophobic binding site for arylesters/lactones and the paraoxon binding site for phosphotriesters
-
-
?
additional information
?
-
the enzyme is located on high-density lipoprotein and prevents low-density-lipoprotein and high-density-lipoprotein oxidation both in vivo and in vitro through hydrolysis of lipid peroxides, the risk of ischemic stroke is related to the genotype of PON1 192RQ polymorphisms, overview
-
-
?
additional information
?
-
-
the enzyme is located on high-density lipoprotein and prevents low-density-lipoprotein and high-density-lipoprotein oxidation both in vivo and in vitro through hydrolysis of lipid peroxides, the risk of ischemic stroke is related to the genotype of PON1 192RQ polymorphisms, overview
-
-
?
additional information
?
-
does not hydrolyse demeton-S-methyl
-
-
?
additional information
?
-
-
does not hydrolyse demeton-S-methyl
-
-
?
additional information
?
-
exhibits diazoxonase, paraoxonase, and arylesterase activities
-
-
?
additional information
?
-
paraoxonase 1 enzyme with three activities, which are paraoxonase, arylesterase and diazoxonase
-
-
?
additional information
?
-
-
paraoxonase 1 enzyme with three activities, which are paraoxonase, arylesterase and diazoxonase
-
-
?
additional information
?
-
-
PON1 catalyses the hydrolysis of arylesters, toxic organophosphate compounds, carbamates and lactones, shows higher arylesterase than paraoxonase activity
-
-
?
additional information
?
-
PON1 contains paraoxonase and arylesterase activities
-
-
?
additional information
?
-
-
PON1 contains paraoxonase and arylesterase activities
-
-
?
additional information
?
-
PON1 hydrolyzes organophosphates, arylesters and lactones, whereas the lactones activity is assumed as the physio/pathological one
-
-
?
additional information
?
-
PON1 is an high density lipoprotein-associated enzyme with three activities: paraoxonase, arylesterase and dyazoxonase
-
-
?
additional information
?
-
-
PON1 is an high density lipoprotein-associated enzyme with three activities: paraoxonase, arylesterase and dyazoxonase
-
-
?
additional information
?
-
rhPON3 can effectively delay and inhibit oxidation of high density lipoprotein in vitro
-
-
?
additional information
?
-
-
rhPON3 can effectively delay and inhibit oxidation of high density lipoprotein in vitro
-
-
?
additional information
?
-
the enzyme can delay and inhibit low-density lipoprotein oxidation in a dose-dependent manner
-
-
?
additional information
?
-
the enzyme contains arylesterase, paraoxonase, and lactonase activities
-
-
?
additional information
?
-
-
the enzyme contains arylesterase, paraoxonase, and lactonase activities
-
-
?
additional information
?
-
the phenyl acetate esterase activity of paraoxonase-1 shows normal solvent kinetic isotope effects, while proton inventory analysis indicates that two protons contribute to the kinetic isotope effect. Moderate competitive inhibition with the phenyl methylphosphonate anion reveals that the rate-limiting transition state suboptimally resembles the tetrahedral intermediate. Despite the presence of the Ca2+-promoted oxyanion hole, the catalytic power can be mostly rationalized by concerted two-proton exchange reorganisation at the active site
-
-
?
additional information
?
-
-
the phenyl acetate esterase activity of paraoxonase-1 shows normal solvent kinetic isotope effects, while proton inventory analysis indicates that two protons contribute to the kinetic isotope effect. Moderate competitive inhibition with the phenyl methylphosphonate anion reveals that the rate-limiting transition state suboptimally resembles the tetrahedral intermediate. Despite the presence of the Ca2+-promoted oxyanion hole, the catalytic power can be mostly rationalized by concerted two-proton exchange reorganisation at the active site
-
-
?
additional information
?
-
-
the rate-limiting step is the nucleophilic attack of the carbonyl group of the substrate by a water molecule. The active site is preorganized with no induced fit, and the enzyme-bound calcium plays an important role in stabilizing both the substrate and the transition state
-
-
?
additional information
?
-
no activity with ethyl acetate, ethyl propionate, ethyl butanoate, ethyl pentanoate, propyl acetate, butyl acetate, hexanoyl acetate, and 4-nitrophenyl esters of chain length C10-C16
-
?
additional information
?
-
-
no activity with ethyl acetate, ethyl propionate, ethyl butanoate, ethyl pentanoate, propyl acetate, butyl acetate, hexanoyl acetate, and 4-nitrophenyl esters of chain length C10-C16
-
?
additional information
?
-
substrate specificity, no activity with 4-nitrophenyl caprate, 4-nitrophenyl laurate, 4-nitrophenyl phosphate, 4-nitrophenyl sulfate, 4-nitrophenyl beta-D-glucuronide, 4-nitrophenyl phenylphosphonate, stearoyl-CoA, palmitoyl-CoA, methylacetylsalicylate, ethyl acetate, propyl acetate, isopropyl acetate, butyl acetate, isobutyl acetate, isoamyl acetate, and caproyl acetate
-
?
additional information
?
-
substrate specificity, no activity with 4-nitrophenyl caprate, 4-nitrophenyl laurate, 4-nitrophenyl phosphate, 4-nitrophenyl sulfate, 4-nitrophenyl beta-D-glucuronide, 4-nitrophenyl phenylphosphonate, stearoyl-CoA, palmitoyl-CoA, methylacetylsalicylate, ethyl acetate, propyl acetate, isopropyl acetate, butyl acetate, isobutyl acetate, isoamyl acetate, and caproyl acetate
-
?
additional information
?
-
-
substrate specificity, no activity with 4-nitrophenyl caprate, 4-nitrophenyl laurate, 4-nitrophenyl phosphate, 4-nitrophenyl sulfate, 4-nitrophenyl beta-D-glucuronide, 4-nitrophenyl phenylphosphonate, stearoyl-CoA, palmitoyl-CoA, methylacetylsalicylate, ethyl acetate, propyl acetate, isopropyl acetate, butyl acetate, isobutyl acetate, isoamyl acetate, and caproyl acetate
-
?
additional information
?
-
-
does not use paraoxon as a substrate
-
-
?
additional information
?
-
PON1 is a lipo-lactonase which is associated with high density lipoprotein and possesses antioxidative properties
-
-
?
additional information
?
-
-
PON1 is a lipo-lactonase which is associated with high density lipoprotein and possesses antioxidative properties
-
-
?
additional information
?
-
molecular docking of substrates to wild-type and mutant enzymes using the crystal structure of PON1 (PDB ID 3SRG with resolution 2.19 A), overview. The enzyme is a paraoxonase (EC 3.1.8.1) that also shows arylesterase activity (EC 3.1.1.2) with phenyl acetate as substrate
-
-
?
additional information
?
-
-
the enzyme exhibits a substrate preference for short-chain fatty-acid esters such as C2 or C4 with an (R)-preference
-
-
?
additional information
?
-
-
can not hydrolyze organophosphates
-
-
?
additional information
?
-
no activity with 4-nitrophenyl decanoate
-
-
?
additional information
?
-
-
no activity with 4-nitrophenyl decanoate
-
-
?
additional information
?
-
no activity with 4-nitrophenyl decanoate
-
-
?
additional information
?
-
no activity with phenyl acetate, 4-nitrophenyl-decanoate or 3-phenyl acetate
-
-
?
additional information
?
-
-
no activity with phenyl acetate, 4-nitrophenyl-decanoate or 3-phenyl acetate
-
-
?
additional information
?
-
no activity with phenyl acetate, 4-nitrophenyl-decanoate or 3-phenyl acetate
-
-
?
additional information
?
-
-
no activity with 4-nitrophenyl caprylate and diclofop methyl
-
?
additional information
?
-
the enzyme has no activity towards 4-nitrophenyl esters with acyl chains longer than C8 like 4-nitrophenyl caprylate, 4-nitrophenyl caprate, 4-nitrophenyl palmitate, as well as 4-nitrophenyl phosphate and methyl parathion
-
-
?
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2-propanol
55% residual activity in the presence of 90% (v/v) 2-propanol, after 60 min at 70°C
6-palmityl-ascorbic acid
-
-
acetonitrile
43% residual activity in the presence of 90% (v/v) acetonitrile, after 60 min at 70°C
Ag+
9.7% residual activity at 5 mM
ascorbate
-
0.5 mM inhibits by ca. 19%. Ascorbate/Cu2+ (0.5 mM/0.001 mM) system shows ca. 91% inactivation
butylated hydroxytoluene
-
-
CdCl2
-
83% residual activity after 24 h in the presence of 0.02 mg/ml CdCl2
Cr3+
39.8% residual activity at 5 mM
D-penicillamine
-
40.5% residual activity after 24 h in the presence of 0.2 mg/ml D-penicillamine
diethyldicarbonate
0.5 mM, complete loss of activity
diisopropyl fluorophosphate
diisopropylfluorophosphate
dimethyl sulfoxide
71% residual activity in the presence of 90% (v/v) dimethyl sulfoxide, after 60 min at 70°C
dimyristoylphosphatidic acid
0.4 mM, 81% inhibition of arylesterase activity, 64% inhibition of paraoxonase activity
dimyristoylphosphatidylserine
no significant inhibition of both paraoxonase and arylesterase activity up to 0.030 mM, remarkable inhibition of both activities at 0.1â0.4 mM, with a greater inhibition of arylesterase activity
dithiothreitol
19.4% residual activity at 5 mM
Fe3+
13.7% residual activity at 5 mM
high density lipoprotein
-
incubation of serum or high density lipoprotein from healthy subjects with very low density lipoprotein significantly decreases serum paraoxonase 1 lactonase or arylesterase activities by up to 11% or 24%, and HDL-associated paraoxonase 1 lactonase or arylesterase activities by up to 32% or 46%, respectively
-
iodoacetic acid
slight inhibition
lanthanum(III) chloride
-
about 50% inhibition at 0.05 mM
methanol
48% residual activity in the presence of 90% (v/v) methanol, after 60 min at 70°C
methylglyoxal
-
decreases specific activity in a concentration-dependent manner
metrifonate
-
50% inhibition at 0.00048 mM, pralidoxime protects
N-ethylmaleimide
-
leads to 24fold reduced enzyme activity at 0.2 mM
organophosphorous compounds
inhibit the enzyme of all genotypes slightly after in vivo exposure
-
phenylmethylsulfonyl fluoride
piperonyl butoxide
-
50% inhibition at 0.6 mM. Enzyme inhibition in vivo reaches a maximum after 4 h and enzyme subsequently recovers over a 24 h period
pyridoxal 5'-phosphate
0.5 mM, 62% residual activity
sodium dodecylsulfate
1 mM, 32% of initial activity
sodium hypochlorite
-
at 1 mM causes approximately 15% decrease in activity, at 1 mM and in the presence of PBS buffer causes approximately 76% decrease in activity
tenoxicam
-
tenoxicam decreases the arylesterase activity of the enzyme during the use of 12 h, in 0.74 mM and 1.48 mM dose
Tween 20
-
51% residual activity at 10% (v/v)
Tween 80
21% residual activity in the presence of 5% (v/v) Tween 80, after 60 min at 70°C
Valproic acid
arylesterase activity is decreased after 60 days of valproic acid treatment
very low density lipoprotein
-
inhibits recombinant paraoxonase 1 lactonase or arylesterase activities by up to 20% or 42%, respectively
-
2-hydroxyquinoline

-
70% inhibition
2-hydroxyquinoline
-
specific paraoxonase 1 inhibitor, dose-dependent inhibition
2-hydroxyquinoline
-
dose-dependent inhibition of enzyme activity against 4-nitrophenyl acetate substrate
2-hydroxyquinoline
-
specific inhibitor
2-hydroxyquinoline
-
specific paraoxonase 1 inhibitor, dose-dependent inhibition
2-hydroxyquinoline
-
dose-dependent inhibition of enzyme activity against 4-nitrophenyl acetate substrate
2-mercaptoethanol

1 mM, 16% of initial activity
2-mercaptoethanol
73.5% residual activity at 5 mM
4-chloromercuribenzoate

-
complete inhibition at 0.2 mM
4-chloromercuribenzoate
-
Ca2+

-
-
Ca2+
88.5% residual activity at 5 mM
Co2+

-
-
Co2+
92.6% residual activity at 5 mM
Cu2+

-
-
Cu2+
-
oxidizes HDL and inactivates HDL-associated paraoxonase1, relationship, overview, the inactivation is enhanced catecholamines, such as 3,4-dihydroxyphenylalanine, dopamine, or norepinephrine, but not by uric acid or homocysteine, low enhancement of Cu2+-mediated enzyme inactivation by catecholamines caffeic acid and pyrocatechol, and by ascorbate, effects on activity of purified enzyme and HDL-complexed enzyme, overview, the inactivation in prevented by several compounds, e.g. by catalase, ethanol, oleic acid, substrate paraoxon, phenylacetate, and slightly by quercetin, mannitol, and DMSO in presence of 1 mM Ca2+
Cu2+
-
0.001 mM inhibits by ca. 13%. Ascorbate/Cu2+ (0.5 mM/0.001 mM) system shows ca. 91% inactivation. Ascorbate/Fe2+ (0.5 mM/0.002 mM) system shows ca. 51% inactivation after 30 min
Cu2+
1 mM, 13% of initial activity
Cu2+
28.9% residual activity at 5 mM
diethyl dicarbonate

6% residual activity in the presence of 5 mM diethyl dicarbonate, after 30 min at 30°C
diethyl dicarbonate
5.5% residual activity at 5 mM
diisopropyl fluorophosphate

-
diisopropyl fluorophosphate
-
diisopropylfluorophosphate

-
competitive inhibition
diisopropylfluorophosphate
-
diisopropylfluorophosphate
complete inactivation at 5 mM diisopropylfluorophosphate, after 30 min at 30°C
EDTA

-
-
EDTA
-
1 mM, completely and irreversibly inhibits activity with phenyl acetate
EDTA
complete inhibition of phenyl acetate hydrolyzing activity
EDTA
-
74% residual activity after 24 h in the presence of 0.05 mg/ml EDTA
EDTA
92% residual activity in the presence of 10 mM EDTA, after 30 min at 75°C
EDTA
94.2% residual activity at 5 mM
EDTA
0.05-10 mM, nearly complete loss of activity
eserine

0.5 mM, 42% residual activity
eserine
92% residual activity in the presence of 5 mM eserine, after 30 min at 30°C
ethanol

63% residual activity in the presence of 90% (v/v) ethanol, after 60 min at 70°C
ethanol
-
with 20% ethanol and 5-10% sodium dodecyl sulfate, whereas no significant changes in presence of 10% ethanol. Mg2+ and Ca2+ have no effect
Fe2+

-
-
Fe2+
-
ascorbate/Fe2+ (0.5 mM/0.002 mM) system shows ca. 51% inactivation after 30 min
Hg2+

-
-
Hg2+
1 mM, 14% of initial activity
Hg2+
complete inactivation at 5 mM Hg2+, after 30 min at 30°C
Hg2+
7.2% residual activity at 5 mM
Mg2+

-
-
Mg2+
activity is strongly reduced when Ca2+ is removed from the purified enzyme and replaced by Zn2+
Mg2+
89.2% residual activity at 5 mM
Mn2+

-
-
Mn2+
85.4% residual activity at 5 mM
NaCl

-
1.0 mM NaCl decreases the serum arylesterase activity of the enzyme
NaCl
76% residual activity in the presence of 2 M NaCl, after 60 min at 70°C
NaCl
43.7% residual activity at 4 M
Ni2+

1 mM, 23% of initial activity
Ni2+
86.3% residual activity at 5 mM
p-chloromercuribenzoate

-
-
p-chloromercuribenzoate
23% residual activity in the presence of 5 mM p-chloromercuribenzoate, after 30 min at 30°C
p-hydroxymercuribenzoate

-
-
p-hydroxymercuribenzoate
-
-
p-hydroxymercuribenzoate
-
-
p-hydroxymercuribenzoate
-
-
p-hydroxymercuribenzoate
-
-
paraoxon

0.5 mM, complete loss of activity
paraoxon
-
mixed type inhibition
Pb2+

-
-
Pb2+
45.7% residual activity at 5 mM
pepstatin A

-
phenyl acetate

-
-
phenyl acetate
-
inhibits hydrolysis of 4-nitrophenyl acetate
Phenylglyoxal

0.5 mM, 77% residual activity
Phenylglyoxal
97% residual activity in the presence of 5 mM phenylglyoxal, after 30 min at 30°C
phenylmethylsulfonyl fluoride

23% residual activity in the presence of 5 mM phenylmethylsulfonyl fluoride, after 30 min at 30°C
phenylmethylsulfonyl fluoride
-
-
phenylmethylsulfonyl fluoride
complete inhibition at 5 mM
PMSF

1 mM
SDS

-
complete inhibition at 5 and 10% (w/v)
SDS
about half of the activity is retained at 1% SDS after incubation for 60 min at 70°C, the addition of 5% SDS completely eliminates the enzyme activity at 70°C
SDS
complete inhibition at 5% (w/v)
Triton X-100

-
61% residual activity at 10% (v/v)
Triton X-100
11% residual activity in the presence of 5% (v/v) Tween 80, after 60 min at 70°C
Urea

88% residual activity in the presence of 8 M urea, after 60 min at 70°C
Urea
-
leads to complete unfolding at 2.0 M
Urea
64.7% residual activity at 8 M
Zn2+

activity is strongly reduced when Ca2+ is removed from the purified enzyme and replaced by Zn2+
Zn2+
76.4% residual activity at 5 mM
additional information

-
not: Cd2+
-
additional information
-
-
-
additional information
-
no inhibition by diisopropyl fluorophosphate and sodium fluoride
-
additional information
-
the enzyme is sensitive to oxidative stress
-
additional information
0.2 mM dimyristoylphosphatidylethanol inhibits paraoxonase activity but has no effect on arylesterase activity
-
additional information
the arylesterase activity of PON1 is not correlated with plasma concentrations of total cholesterol, low density lipoprotein-cholesterol, high density lipoprotein-cholesterol, or triacylglycerol in atherosclerosis obliterans patients
-
additional information
-
the arylesterase activity of PON1 is not correlated with plasma concentrations of total cholesterol, low density lipoprotein-cholesterol, high density lipoprotein-cholesterol, or triacylglycerol in atherosclerosis obliterans patients
-
additional information
high plasma C-reactive protein is related to low paraoxonase-I activity
-
additional information
-
1 mM 3-morpholinosydnoimine, 0.002 mM Fe2+ or 0.01 mM Mn2+, Co2+, Zn2+ cause no significant loss of activity
-
additional information
-
crystalline particles Min-U-Sil 5 reduce activity due to decreased protein concentrations
-
additional information
-
not inhibited by diclofenac sodium
-
additional information
no inhibition by EDTA and iodoacetic acid
-
additional information
infection with the intestinal nematode Nippostrongylus brasiliensis leads to decreased PON1 serum activity
-
additional information
-
infection with the intestinal nematode Nippostrongylus brasiliensis leads to decreased PON1 serum activity
-
additional information
-
ethanol consumption causes a decrease in liver arylesterase activity, which is not significant. Gallic acid treatment restores the loss of this activity due to ethanol exposure. Ethanol consumption causes a significant decrease in liver paraoxonase activity, gallic acid treatment partly restores this decreased paraoxonase activity
-
additional information
addition of glycerin has no effect on the enzyme activity
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
1,2-dilauroyl-phosphatidylcholine
-
stimulation
1-palmitoyl-2-arachidonoylphosphatidylcholine
stimulates arylesterase activity
1-palmitoyl-2-linoleoylphosphatidylcholine
stimulates arylesterase activity
3-[(3-cholamidopropyl)-dimethylammonio]-1-propanesulfonate
the enzyme is activated by 87% by incubation with 1% (w/v) 3-[(3-cholamidopropyl)-dimethylammonio]-1-propanesulfonate, at 30°C
aspirin
induces enzyme expression in the liver and stimulates enzymatic activity in blood plasma
cyclophosphamide
22% increase in the activity of PON1 in the liver and 23% increase in PON1 activity in the serum is observed 24 h after treatment with a single dose of 150 mg/kg cyclophosphamide
cysteine
1 mM, 117% of initial activity
di-oleoyl phosphatidylcholine
2.6 mM di-oleoyl phosphatidylcholine stimulates arylesterase activity of PON1 3.5fold
didecanoylphosphatidylcholine
stimulation of arylesterase activity is greater than stimulation of paraoxonase activity
dilauroyl phosphatidylcholine
dilauroylphosphatidylcholine
stimulation of arylesterase activity is greater than stimulation of paraoxonase activity
dilinoleoylphosphatidylcholine
stimulates arylesterase activity
dimethyl sulfoxide
21% increase of activity at 50% (v/v) dimethyl sulfoxide, at 30°C
dimyristoyl phosphatidylcholine
dimyristoylphosphatidylcholine
stimulation of arylesterase activity is greater than stimulation of paraoxonase activity
dimyristoylphosphatidylglycerol
activates the arylesterase activity and inhibits paraoxonase activity
dioleoyl phosphatidylcholine
dipalmitoylphosphatidylcholine
stimulation of arylesterase activity is greater than stimulation of paraoxonase activity
high-density lipoprotein
paraoxonase and arylesterase activities are stimulated by high-density lipoprotein by 2-5fold, almost independently of the apoliporotein content
-
Lubrol
the enzyme is activated by 14% by incubation with 1% Lubrol, at 30°C
-
lysophosphatidylinositol
0.01 mM, 10% stimulation of arylesterase activity
Mg2+
-
Mg2, Mn2+ and other divalent metal ions can not substitute for Ca2+ and lead to a loss od arylesterase activty
Mn2+
-
Mg2, Mn2+ and other divalent metal ions can not substitute for Ca2+ and lead to a loss od arylesterase activty
monooleoyl-lysophosphatidylserine
0.01 mM, 8% stimulation of arylesterase activity
Nonidet P-40
8.2% activation at 5% (v/v)
palmitoyl-lysophosphatidylglycerol
0.01 mM, 47% stimulation of arylesterase activity
paraoxon
115 increase of activita in the presence of 0.5 mM paraoxon, after 30 min at 30°C
phosphatidylcholine
-
purified A or B-type esterases are stimulated
phosphatidylinositol
enhances arylesterase activity, but slightly decreases paraoxonase activity
phosphatidylsenine
-
stimulates
-
pyridoxal 5'-phosphate
110% activity in the presence of 5 mM pyridoxal 5'-phosphate, after 30 min at 30°C
salicylic acid
induces enzyme expression in the liver and stimulates enzymatic activity in blood plasma
sphingomyelin
-
stimulates
Tween 40
16.4% activation at 5% (v/v)
dilauroyl phosphatidylcholine

-
stimulates
dilauroyl phosphatidylcholine
stimulates activity of enzyme variants Q192 and R192
dimyristoyl phosphatidylcholine

-
stimulates
dimyristoyl phosphatidylcholine
-
stimulates
dioleoyl phosphatidylcholine

-
stimulates
dioleoyl phosphatidylcholine
-
stimulation
dioleoyl phosphatidylcholine
-
stimulates
ethanol

4%, 150% of initial activity, 12%, 120% of intial activity
ethanol
15% increase of activity at 50% (v/v) ethanol, at 30°C
lecithin

-
stimulates
lysolecithin

-
stimulates
lysolecithin
-
stimulation
lysolecithin
-
stimulates
NaCl

-
-
NaCl
maximal activity at 35°C at 15%
NaCl
optimal concentration is 3.5% at 35°C
phosphate

-
preserves activity with considerable fluctuations, modulates oligomeric state
phosphatidylethanolamine

-
stimulates
phosphatidylethanolamine
-
stimulation
phosphatidylethanolamine
-
stimulates
phosphatidylglycerol

-
stimulation
phosphatidylglycerol
-
stimulates
Triton X-100

1 mM, 122% of initial activity
Triton X-100
11.2% activation at 5% (v/v)
Tween 20

1 mM, 116% of initial activity
Tween 20
the enzyme is activated by 67% by incubation for 60 min with 1% (v/v) Tween 20 at 30°C
Tween 20
4.8% activation at 5% (v/v)
Tween 80

1 mM, 115% of initial activity
Tween 80
19.6% activation at 5% (v/v)
additional information

arylesterase activity is independently correlated with high density lipoprotein cholesterol and lipid hydroperoxide levels
-
additional information
-
arylesterase activity is independently correlated with high density lipoprotein cholesterol and lipid hydroperoxide levels
-
additional information
pomegranate juice and pomegranate polyphenol extract (from variety Wonderful) consumption contributes to PON1 stabilization, increased association with high density lipoprotein, and enhanced catalytic activity
-
additional information
-
pomegranate juice and pomegranate polyphenol extract (from variety Wonderful) consumption contributes to PON1 stabilization, increased association with high density lipoprotein, and enhanced catalytic activity
-
additional information
-
after anti-tumour necrosis factor therapy, arylesterase significantly increases after 2 weeks from the first infusion and also remains high after 6 months
-
additional information
-
binding of human phosphate binding protein amends the size of the oligomeric states and exerts a stabilizing effect on the activity
-
additional information
serum arylesterase activity is positively correlated with serum total cholesterol and low density lipoprotein and very low density lipoprotein-cholesterol concentrations
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
0.039 - 0.041
1-naphthyl acetate
0.369
1-naphthyl butyrate
-
immobilized cross-linked enzyme aggregate, at pH 7.0 and 25°C
5
1-phenylvinyl acetate
-
19
2,2,2-trifluoroethyl acetate
-
24.8
2,2-difluoroethyl acetate
-
1.19
2,3-difluorophenyl acetate
-
2.23
2,4-difluorophenyl acetate
-
2
2,6-difluorophenyl acetate
-
54
2-fluoroethyl acetate
-
1.5
2-fluorophenyl acetate
-
0.0079 - 0.65
2-naphthyl acetate
0.0128
2-naphthyl butanoate
pH 7.0, 25°
0.1
2-naphthyl butyrate
-
immobilized cross-linked enzyme aggregate, at pH 7.0 and 25°C
2.1
3,4-dimethyl phenyl acetate
-
1.9
3-cyanophenyl acetate
-
1.4
3-fluorophenyl acetate
-
0.0052
3-naphthyl acetate
pH 7.0, 25°
0.0088
3-naphthyl butanoate
pH 7.0, 25°
2.2
3-nitrophenyl acetate
-
2
4-acetoxy methyl benzoate
-
2.6
4-acetoxyacetophenone
-
2.3
4-acetoxybenzaldehyde
1
4-chlorophenyl acetate
-
4.1
4-methoxy phenyl acetate
-
0.000043 - 8.19
4-nitrophenyl acetate
0.174 - 0.38
4-nitrophenyl butanoate
0.072 - 0.224
4-nitrophenyl butyrate
0.081
4-nitrophenyl caprate
recombinant wild type enzyme, in 100 mM sodium phosphate buffer (pH 7.0), at 60°C
0.031
4-nitrophenyl caproate
recombinant wild type enzyme, in 100 mM sodium phosphate buffer (pH 7.0), at 60°C
0.028
4-nitrophenyl caprylate
recombinant wild type enzyme, in 100 mM sodium phosphate buffer (pH 7.0), at 60°C
0.084
4-nitrophenyl decanoate
EstB, pH 7.5, 30°C
0.029
4-nitrophenyl hexanoate
EstB, pH 7.5, 30°C
0.122
4-nitrophenyl laurate
recombinant wild type enzyme, in 100 mM sodium phosphate buffer (pH 7.0), at 60°C
0.23
4-nitrophenyl octanoate
EstB, pH 7.5, 30°C
0.276
4-nitrophenyl palmitate
recombinant wild type enzyme, in 100 mM sodium phosphate buffer (pH 7.0), at 60°C
0.063
4-nitrophenyl pentanoate
EstB, pH 7.5, 30°C
0.234
4-nitrophenyl phosphate
recombinant wild type enzyme, in 100 mM sodium phosphate buffer (pH 7.0), at 60°C
1.4
4-nitrophenyl propionate
EstB, pH 7.5, 30°C
74.6 - 98.7
7-aminocephalosporanic acid
0.029 - 0.19
Alpha-naphthyl acetate
2.1
beta-naphthyl acetate
-
-
119 - 174.7
cephalosporin C
3.2
ethyl hexanoate
EstB, pH 7.5, 30°C
1.6
ketoprofen ethyl ester
-
at pH 8.0
0.043 - 0.29
p-nitrophenyl acetate
1.42
paraoxon
pH 7.4, 25°C
5.5
phenylthioacetate
EstB, pH 7.5, 30°C
7.1 - 7.2
S-methyl thiobutanoate
additional information
9-(4-chlorophenyloxycarbonyl)-10-methylacridinium triflate
0.039
1-naphthyl acetate

-
immobilized cross-linked enzyme aggregate, at pH 7.0 and 25°C
0.041
1-naphthyl acetate
in 50 mM Tris-HCl (pH 8.0), at 37°C
0.0079
2-naphthyl acetate

pH 7.0, 25°
0.014
2-naphthyl acetate
-
immobilized cross-linked enzyme aggregate, at pH 7.0 and 25°C
0.16
2-naphthyl acetate
pH 8.0, recombinant genetic variant G1A7
0.18
2-naphthyl acetate
pH 8.0, recombinant genetic variant G1B11
0.211
2-naphthyl acetate
pH 8.0
0.26
2-naphthyl acetate
pH 8.0, recombinant genetic variant G2C2
0.5
2-naphthyl acetate
pH 8.0
0.65
2-naphthyl acetate
pH 8.0, recombinant genetic variant G3G3
2.3
4-acetoxybenzaldehyde

-
2.3
4-acetoxybenzaldehyde
recombinant enzyme
0.000043
4-nitrophenyl acetate

-
37°C, pH 7.6
0.0174
4-nitrophenyl acetate
pH 7.0, 25°
0.094
4-nitrophenyl acetate
-
immobilized cross-linked enzyme aggregate, at pH 7.0 and 25°C
0.124
4-nitrophenyl acetate
pH 8.0, 25°C
0.289
4-nitrophenyl acetate
-
in 20 mM Tris-HCl buffer, pH 7.4, 1 mM CaCl2, temperature not specified in the publication
0.336
4-nitrophenyl acetate
-
in 20 mM Tris-HCl buffer, pH 7.4, 1 mM CaCl2, temperature not specified in the publication
0.611
4-nitrophenyl acetate
-
recombinant enzyme, in 20 mM Tris-HCl buffer, pH 7.4, 1 mM CaCl2, temperature not specified in the publication
0.96
4-nitrophenyl acetate
in 50 mM Tris-HCl (pH 8.0), at 37°C
1.5
4-nitrophenyl acetate
-
1.9
4-nitrophenyl acetate
EstB, pH 7.5, 30°C
2.11
4-nitrophenyl acetate
pH 8.3, 25°C
4.2
4-nitrophenyl acetate
-
pH 7.2, 37°C
8.19
4-nitrophenyl acetate
pH 6.5, 50°C
0.174
4-nitrophenyl butanoate

pH 7.0, 25°
0.38
4-nitrophenyl butanoate
EstB, pH 7.5, 30°C
0.072
4-nitrophenyl butyrate

-
immobilized cross-linked enzyme aggregate, at pH 7.0 and 25°C
0.224
4-nitrophenyl butyrate
recombinant wild type enzyme, in 100 mM sodium phosphate buffer (pH 7.0), at 60°C
74.6
7-aminocephalosporanic acid

-
immobilized cross-linked enzyme aggregate, at pH 8.0 and 30°C
98.7
7-aminocephalosporanic acid
-
free enzyme, at pH 8.0 and 30°C
0.029
Alpha-naphthyl acetate

recombinant wild type enzyme, in 100 mM sodium phosphate buffer (pH 7.0), at 60°C
0.19
Alpha-naphthyl acetate
-
-
119
cephalosporin C

-
free enzyme, at pH 8.0 and 30°C
174.7
cephalosporin C
-
immobilized cross-linked enzyme aggregate, at pH 8.0 and 30°C
0.043
p-nitrophenyl acetate

-
-
0.29
p-nitrophenyl acetate
-
-
0.01
phenyl acetate

pH 7.0, 25°
0.014
phenyl acetate
wild type enzyme, in simulated body fluid, at pH 7.34-7.4 and 37°C
0.017
phenyl acetate
recombinant wild type enzyme, in 100 mM sodium phosphate buffer (pH 7.0), at 60°C
0.069
phenyl acetate
-
immobilized cross-linked enzyme aggregate, at pH 7.0 and 25°C
0.201
phenyl acetate
wild type enzyme, in 20 mM Tris-HCl and 0.9 mM CaCl2, at pH 8 and 25°C
0.265
phenyl acetate
-
pH 7.4, 37°C, type B paraoxonase
0.265
phenyl acetate
-
pH 8.0, 25°C, enzyme from phenotype B blood plasma
0.27
phenyl acetate
enzyme variant R192
0.4
phenyl acetate
-
enzyme of breed Holstein, pH 8.0, 25°C
0.46
phenyl acetate
wild type enzyme, in simulated body fluid, at pH 7.34-7.4 and 37°C
0.5
phenyl acetate
-
in 50 mM Tris-HCl buffer, 10 mM CaCl2, pH 7.4
0.5
phenyl acetate
-
enzyme of breed Montofon, pH 8.0, 25°C
0.51
phenyl acetate
mutant E313A, pH 8.0, 25°C
0.53
phenyl acetate
in 50 mM Tris-HCl (pH 8.0), at 37°C
0.59
phenyl acetate
mutant N133S, pH 8.0, 25°C
0.61
phenyl acetate
wild-type, pH 8.0, 25°C
0.61
phenyl acetate
pH 8.0, 25°C, wild-type enzyme
0.64
phenyl acetate
mutant G11S, pH 8.0, 25°C
0.64
phenyl acetate
wild type enzyme, in 20 mM Tris-HCl and 0.9 mM CaCl2, at pH 8 and 25°C
0.67
phenyl acetate
mutant E314A, pH 8.0, 25°C
0.68
phenyl acetate
-
pH 8.0, 10°C
0.688
phenyl acetate
-
pH 7.4, 37°C, type A paraoxonase
0.688
phenyl acetate
-
pH 8.0, 25°C, enzyme from phenotype A blood plasma
0.7
phenyl acetate
enzyme variant Q192
0.74
phenyl acetate
mutant G11A or mutant G11C, pH 8.0, 25°C
0.74
phenyl acetate
-
2 mM substrate, at pH 8.0 and 37°C
0.8
phenyl acetate
pH 8.3, activity buffer with 0.01 mM apolipoprotein apoA-I rHDL
0.8
phenyl acetate
-
enzyme of breed Swiss Black, pH 8.0, 25°C
0.81
phenyl acetate
pH 8.0, 25°C, mutant enzyme F222Y
0.86
phenyl acetate
wild type enzyme, in 50 mM Tris-HCl with 1 mM CaCl2 (pH 8.0), at 25°C
0.89
phenyl acetate
mutant F222Y, pH 8.0, 25°C
0.89
phenyl acetate
mutant enzyme Q192R, in 50 mM Tris-HCl with 1 mM CaCl2 (pH 8.0), at 25°C
0.92
phenyl acetate
-
isozyme 192R, in 50 mM Tris-HCl (pH 8.0), 1 mM CaCl2, 25°C
0.957
phenyl acetate
recombinant wild type enzyme, in 0.1 M Tris-HCl (pH 8.5), 2 M NaCl, and 2 mM CaCl2
0.97
phenyl acetate
-
pH 8.0, 15°C
0.98
phenyl acetate
-
isozyme 192Q, in 50 mM Tris-HCl (pH 8.0), 1 mM CaCl2, 25°C
1 - 2.1
phenyl acetate
-
-
1.05
phenyl acetate
-
pH 8.0, 20°C
1.2
phenyl acetate
recombinant enzyme
1.3
phenyl acetate
pH 8.0, wild-type enzyme
1.33
phenyl acetate
-
pH 8.0, 25°C
1.6
phenyl acetate
pH 8.3, activity buffer with 0.1% tergitol
1.8
phenyl acetate
-
pH 8.0, 30°C
2.07
phenyl acetate
-
pH 8.0, 35°C
2.1
phenyl acetate
wild-type, pH 8.0, 25°C
2.1
phenyl acetate
pH 8.0, temperature not specified in the publication
2.6
phenyl acetate
pH 8.3, activity buffer
3.03
phenyl acetate
-
pH 8.0, 40°C
3.6
phenyl acetate
pH 8.0, mutant enzyme H134Q
3.7
phenyl acetate
-
pH 8.0, wild-type enzyme
3.8
phenyl acetate
-
pH 8.0, recombinant enzyme
4.1
phenyl acetate
mutant H115W/R192K, pH 8.0, 25°C
7.46
phenyl acetate
pH 8.0, 37°C
7.47
phenyl acetate
pH 8.0, 37°C
8.1
phenyl acetate
pH 8.0, mutant enzyme H115Q
8.18
phenyl acetate
pH 8.3, 25°C
9.7
phenyl acetate
pH 8.0, mutant enzyme H115Q/H134Q
10.8
phenyl acetate
mutant H115W, pH 8.0, 25°C
16
phenyl acetate
EstB, pH 7.5, 30°C
7.1
S-methyl thiobutanoate

-
immobilized cross-linked enzyme aggregate, at pH 7.0 and 25°C
7.2
S-methyl thiobutanoate
pH 8.0, 25°
additional information
9-(4-chlorophenyloxycarbonyl)-10-methylacridinium triflate

-
Km value of a serum sample is 85 nM, pH 8.0, 25°C
additional information
additional information
-
kinetics
-
additional information
additional information
-
Km-values in serum samples
-
additional information
additional information
-
all kinetic parameters increase with temperature, but the ratios kcat/Km and Kp/Km remain practically constant
-
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