EC Number   |
Natural Substrates |
|---|
   2.4.1.165 | more |
involved in formation of blood group Sda/CAD antigen |
| 2.4.1.165 | UDP-N-acetyl-D-galactosamine + alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide |
- |
| 2.4.1.165 | UDP-N-acetyl-D-galactosamine + alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide |
enzymic activity correlates with the degree of enterocytic differentiation |
| 2.4.1.165 | UDP-N-acetyl-D-galactosamine + alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide |
responsible for addition of the immunodominant sugar of the Sda-isto-blood-group determinant |
| 2.4.1.165 | UDP-N-acetyl-D-galactosamine + alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide |
overexpression of the enzyme in skeletal muscles inhibits muscular dystrophy in mdx mice. The enzyme produces the terminal beta1,4GalNAc linkage on the cytotoxic T cell carbohydrate antigen which is also localized to the neuromuscular junction in adult animals |
| 2.4.1.165 | UDP-N-acetyl-D-galactosamine + alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide |
the enzyme can affect the post-translational processing of dystroglycan and the extent of muscular dystrophy even in muscles where the VIA4-1 antigen is not present |
| 2.4.1.165 | UDP-N-acetyl-D-galactosamine + NeuAcalpha(2-3)Galbeta(1-4)Glc |
responsible for the final step in the formation of the Sda/Cad antigenic epitopes, Sd(alpha) beta4GalNAcT-II mRNA transcript is drastically reduced in oncogenetic processes in gastrointestinal tissues |
