EC Number   |
Natural Substrates |
|---|
    6.3.1.2 | ATP + L-Glu + NH4+ |
- |
| 6.3.1.2 | ATP + L-Glu + NH4+ |
isoenzyme GS1b (EC 6.3.1.2) in concert with NADH-dependent GOGAT (EC 1.4.1.14) constitute the major route of assimilation of ammonium derived from reserve mobilization and glutamic acid/glutamine synthesis in germinating Medicago truncatula seeds. However, during post-germinative growth, although germination is held in darkness, expression of GS2 and Fd-GOGAT (EC 1.4.7.1) increases and expression of GS1b decreases in cotyledons but not in the embryo axis |
| 6.3.1.2 | ATP + L-Glu + NH4+ |
serves for assimilation of ammonium in rice root, and ameliorates the toxic effect of ammonium excess |
| 6.3.1.2 | ATP + L-Glu + NH4+ |
roles of the enzyme in pathogenesis of Mycobacterium tuberculosis infection: 1. synthesis of Glu, that is a major component of the cell wall of pathogenic mycobacteria, 2. modulation of the NH4+ level in the Mycobacterium tuberculosis phagosome |
| 6.3.1.2 | ATP + L-Glu + NH4+ |
first step in urea synthesis |
| 6.3.1.2 | ATP + L-Glu + NH4+ |
first step at which nitrogen is brought into cellular metabolism, the product Glu, a source of nitrogen in the biosynthesis of many other metabolites |
| 6.3.1.2 | ATP + L-Glu + NH4+ |
glutamine produced by the enzyme serves as a source of nitrogen atoms in the biosynthesis of all amino acids, purine and pyrimidine nucleotides, of glucosamine 6-phosphate, 4-aminobenzoic acid, and of nicotinamide derivatives. Glutamine synthetase links the assimilation of NH4+ with biosynthetic pathways leading to the formation of proteins, nucleic acids, complex polysaccharides, and different coenzymes |
| 6.3.1.2 | ATP + L-Glu + NH4+ |
glutamate synthetase cycle provides the only efficient pathway for the conversion of inorganic nitrogen to the organic form |
| 6.3.1.2 | ATP + L-Glu + NH4+ |
kinetic regulation of this enzyme may play a significant role in ammonia detoxication and rate of formation of Gln-derived neurotransmitters in fish brain |
| 6.3.1.2 | ATP + L-glutamate + NH3 |
- |
