EC Number   |
Natural Substrates |
|---|
    1.1.1.284 | S-(hydroxymethyl)glutathione + NAD(P)+ |
multifunctional enzyme, large active site pocket of enzyme entails special substrate specificities: short-chain alcohols are poor substrates, while medium-chain alcohols and particularly the glutathione adducts S-hydroxymethylglutathioneand S-nitrosoglutathione are efficiently converted, universal presence and structural conservation imply that ADH3 performs essential housekeeping functions in living organisms |
| 1.1.1.284 | S-(hydroxymethyl)glutathione + NAD+ |
- |
| 1.1.1.284 | S-(hydroxymethyl)glutathione + NAD+ |
essential role in formaldehyde detoxifcation |
| 1.1.1.284 | S-(hydroxymethyl)glutathione + NAD+ |
the enzyme plays an important role in the formaldehyde detoxification and reduction of the nitric oxide metabolite |
| 1.1.1.284 | S-nitrosoglutathione + NAD(P)H + H+ |
- |
| 1.1.1.284 | S-nitrosoglutathione + NADH |
the enzyme provides a defense mechanism against nitrosative stress, enzymatic pathway that modulates the bioactivity and toxicity of NO |
| 1.1.1.284 | S-nitrosoglutathione + NADH |
- |
| 1.1.1.284 | S-nitrosoglutathione + NADH + H+ |
ADH3 can affect the transnitrosation equilibrium between S-nitrosoglutathione and S-nitrosated proteins, arguing for an important role in NO homeostasis |
| 1.1.1.284 | S-nitrosoglutathione + NADH + H+ |
- |
| 1.1.1.284 | S-nitrosoglutathione + NADPH + H+ |
- |
