EC Number |
Inhibitors |
Structure |
---|
2.7.7.64 | more |
identification of structurally diverse scaffolds for the development of USP inhibitors by fragment library screening, selection of small molecule inhibitors with allosteric regulation sites, that inhibit both Leishmania major USP and UGP. Inhibitor binding kinetics, computational docking study, overview |
|
2.7.7.64 | ATP |
- |
|
2.7.7.64 | ADP |
at higher concentrations above 6 mM |
|
2.7.7.64 | diphosphate |
- |
|
2.7.7.64 | EDTA |
- |
|
2.7.7.64 | EDTA |
complete inhibition |
|
2.7.7.64 | nitric oxide |
inactivation, reactivation by reduction using cysteine or thioredoxin |
|
2.7.7.64 | hydrogen peroxide |
inactivation, reactivation by reduction using cysteine or thioredoxin |
|
2.7.7.64 | (3R)-1-(4-chlorobenzoyl)-N-(3,4-dihydro-2H-1,5-benzodioxepin-7-yl)piperidine-3-carboxamide |
compound (3R)-1-(4-chlorobenzoyl)-N-(3,4-dihydro-2H-1,5-benzodioxepin-7-yl)piperidine-3-carboxamide preferentially binds to one site located in the proximity of the active center of the enzyme |
|
2.7.7.64 | 2-(5,6-dimethylthieno[2,3-d]pyrimidin-4-yl)oxybenzamide |
- |
|