EC Number |
Inhibitors |
Structure |
---|
2.1.1.137 | glutathione |
addition of 20 mM GSH sharply inhibits methylation |
|
2.1.1.137 | HgCl2 |
- |
|
2.1.1.137 | GSH |
suppression of formation of trimethylarsine oxide, stimulatory effect on the rate of methylarsonate and dimethylarsinate production from arsenite is concentration-dependent |
|
2.1.1.137 | GSH |
addition of GSH stimulates the overall rate for As methylation, but inhibits formation of trimethylarsenite |
|
2.1.1.137 | arsenite |
the enzyme activity is completely inhibited by elevated concentrations of the substrate arsenite (0.2 mM) |
|
2.1.1.137 | Selenite |
50% inhibition with 0.0126 mM selinite |
|
2.1.1.137 | Selenite |
addition of selenite at 1:10 molar ratio with arsenite in the reaction mixture completely abolishes the arsenic methylation |
|
2.1.1.137 | selenate |
more than 1 mM selenate necessary for 50% inhibition |
|
2.1.1.137 | Sodium selenite |
- |
|
2.1.1.137 | dimethylselenoxide |
weak activator of recombinant As(III)-methyltransferase, weak inhibitor of arsenite methylation in hepatocytes |
|