EC Number |
Inhibitors |
Structure |
---|
6.3.4.14 | 6-(2,6-dibromophenyl)pyrido[2,3-d]pyrimidine-2,7-diamine |
targets the ATP-binding site of biotin carboxylase. Biophysics of binding, crystallization data. Effective in vivo and in vitro, selective for bacterial biotin carboxylase. Pharmacological studies in rat and mouse |
|
6.3.4.14 | 6-(2,6-dimethoxyphenyl)pyrido[2,3-d]pyrimidine-2,7-diamine |
targets the ATP-binding site of biotin carboxylase. Biophysics of binding, crystallization data. Effective in vivo and in vitro, selective for bacterial biotin carboxylase. Pharmacological studies in rat and mouse |
|
6.3.4.14 | adenosine diphosphopyridoxal |
ATP, ADP, inorganic phosphate and bicarbonate protect against inhibition |
|
6.3.4.14 | ADP |
- |
|
6.3.4.14 | ATP |
the catalytic activity can be inhibited by ATP at high concentrations |
|
6.3.4.14 | ATP |
ATP shows substrate inhibition which is competitive against bicarbonate |
|
6.3.4.14 | biotin |
above 300 mM, noncompetitive substrate inhibitor |
|
6.3.4.14 | Co2+ |
above 2 mM |
|
6.3.4.14 | CTP |
less than 40% residual activity at 20 mM |
|
6.3.4.14 | ethanol |
maximal activation, 10fold, at 15% v/v. Inactivation at 20% v/v |
|