Ligand CTP

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Basic Ligand Information

Molecular Structure

Picture of CTP (click for magnification)

C₉H₁₆N₃O₁₄P₃

CTP

PCDQPRRSZKQHHS-XVFCMESISA-N

Synonyms:

5'-CTP, cytidine triphosphate, D-CTP

BRENDA

CDP-diacylglycerol biosynthesis, chlorophyll metabolism, CMP-KDO biosynthesis, coenzyme A metabolism, dolichol and dolichyl phosphate biosynthesis

more

KEGG

Mannose type O-glycan biosynthesis, Pyrimidine metabolism

MetaCyc

alpha-dystroglycan glycosylation, CDP-4-dehydro-3,6-dideoxy-D-glucose biosynthesis, CDP-archaeol biosynthesis, CDP-D-arabitol biosynthesis, CDP-D-mannitol biosynthesis

more

Show all BRENDA pathways known for CTP

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Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (80 results)

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2.5.1.17

cob(I)alamin + CTP + H2O + H+ = cytosylcobalamin + diphosphate + phosphate

674576

2.7.1.108

CTP + dolichol = CDP + dolichyl phosphate

696448, 640391, 640395, 640399, 640392, 640396, 640394, 640398, 739079, 739314, 640393, 640401, 640390, 671201

2.7.1.174

CTP + 1,2-diacyl-sn-glycerol = CDP + 1,2-diacyl-sn-glycerol 3-phosphate

738595, 693092, 687738

2.7.1.182

CTP + phytol = CDP + phytyl phosphate

738766, 739296, 726159

2.7.7.14

CTP + ethanolamine phosphate = diphosphate + CDP-ethanolamine

675978, 722415, 642882, 642883, 642884, 642887, 721549, 642885, 642888, 642881, 642886, 660968, 660979, 676425

CTP + 2,3-bis-(O-geranylgeranyl)-sn-glycerol 1-phosphate = diphosphate + CDP-2,3-bis-(O-geranylgeranyl)-sn-glycerol

CTP + molybdenum cofactor = diphosphate + cytidylyl molybdenum cofactor

709036, 709163

2.7.7.81

CTP + 5,7-bis(acetylamino)-3,5,7,9-tetradeoxy-L-glycero-alpha-L-manno-2-nonulopyranosonic acid = diphosphate + CMP-5,7-bis(acetylamino)-3,5,7,9-tetradeoxy-L-glycero-alpha-L-manno-2-nonulopyranosonic acid

692521

2.7.7.90

CTP + 8-amino-3,8-dideoxy-alpha-D-manno-octulosonate = diphosphate + CMP-8-amino-3,8-dideoxy-alpha-D-manno-octulosonate

CTP + phosphonoformate = CMP-5'-phosphonoformate + diphosphate

705845

3.6.1.15

CTP + H2O = CDP + phosphate

688347, 684774, 696153, 696275

3.6.1.5

CTP + 2 H2O = CMP + 2 phosphate

720442, 700083

3.6.1.8

CTP + H2O = CMP + diphosphate

CTP + H2O = ?

CTP = 3',5'-cyclic CMP + diphosphate

648784, 648787, 648788, 648789, 648790, 648792, 648791

5.6.1.5

CTP + H2O + polypeptide = CDP + phosphate + unfolded polypeptide

CTP + (R)-4'-phosphopantothenate + L-cysteine = CMP + diphosphate + N-[(R)-4'-phosphopantothenoyl]-L-cysteine

740672

7.2.2.3

CTP + H2O = ?

210276

In Vivo Product in Enzyme-catalyzed Reactions (44 results)

ATP + CDP = ADP + CTP

Substrate in Enzyme-catalyzed Reactions (551 results)

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1.1.98.6

CTP + formate = dCTP + CO2 + H2O

740656, 740665, 740670

1.17.4.1

CTP + reduced thioredoxin = 2'-dCTP + thioredoxin disulfide + H2O

5,10-methylenetetrahydrofolate + CTP = dihydrofolate + 5-methylcytidine 5'-triphosphate

441229

2.5.1.112

dimethylallyl diphosphate + CTP = ?

CTP + L-methionine + H2O = S-cytosyl-L-methionine + phosphate + diphosphate

639074

2.7.1.1

CTP + D-glucose = CDP + D-glucose 6-phosphate

640230, 640240, 640228, 676958, 723049, 739618, 739403, 640237, 640209, 640224, 640234, 640208, 640226, 674266

2.7.1.100

CTP + 5-methylthioribose = CDP + 5-methylthioribose 1-phosphate

640269

2.7.1.105

CTP + D-fructose 6-phosphate = CDP + beta-D-fructose 2,6-bisphosphate

CTP + D-fructose 6-phosphate = CDP + D-fructose 1,6-bisphosphate

640522, 640421, 640484, 640446, 640485, 640443, 640426, 640518, 640442, 640463, 640436, 640509, 640495, 640511, 727544

2.7.1.113

2 entries

2.7.1.12

CTP + D-gluconate = CDP + 6-phospho-D-gluconate

739515

2.7.1.130

CTP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-(beta-D-1,6-)-2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl beta-phosphate = CDP + 2,3,2',3'-tetrakis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-glucosamine 1,4'-bisphosphate

640805

2.7.1.144

CTP + D-tagatose 6-phosphate = CDP + D-tagatose 1,6-bisphosphate

CTP + D-ribose = CDP + D-ribose 5-phosphate

CTP + L-seryl-tRNASec = CDP + O-phospho-L-seryl-tRNASec

3-deoxy-alpha-D-manno-oct-2-ulopyranosyl-(2->6)-2-deoxy-2-[[(3R)-3-hydroxypentadecanoyl]amino]-3-O-[(3R)-3-hydroxytetradecanoyl]-4-O-phosphono-beta-D-glucopyranosyl-(1->6)-2-deoxy-3-O-[(3R)-3-hydroxytetradecanoyl]-2-[[(3R)-3-hydroxytetradecanoyl]amino]-1-O-phosphono-alpha-D-glucopyranose + CTP = 3-deoxy-4-O-phosphono-alpha-D-manno-oct-2-ulopyranosyl-(2->6)-2-deoxy-2-[[(3R)-3-hydroxypentadecanoyl]amino]-3-O-[(3R)-3-hydroxytetradecanoyl]-4-O-phosphono-beta-D-glucopyranosyl-(1->6)-2-deoxy-3-O-[(3R)-3-hydroxytetradecanoyl]-2-[[(3R)-3-hydroxytetradecanoyl]amino]-1-O-phosphono-alpha-D-glucopyranose + CDP

698707

2.7.1.169

CTP + pantoate = CDP + 4-phosphopantoate

722549

2.7.1.17

CTP + 1-deoxy-D-xylulose = CDP + 1-deoxy-D-xylulose 5-phosphate

CTP + phytol = CDP + phytyl phosphate

726159, 738766, 739296, 727856

2.7.1.2

2 entries

2.7.1.20

CTP + adenosine = CDP + AMP

687787, 641106, 721633, 641075, 641093, 641087, 641097, 641095, 675871

2.7.1.21

2 entries

2.7.1.213

cytidine + CTP = CMP + CDP

739025, 734747

2.7.1.216

CTP + (2E,6E)-farnesol = CDP + (2E,6E)-farnesyl phosphate

CTP + adenosine 5-phosphosulfate = CDP + 3'-phosphoadenosine 5'-phosphosulfate

641213, 641211

2.7.1.26

CTP + riboflavin = CTP + riboflavin 5'-phosphate

641252, 641235

2.7.1.29

CTP + dihydroxyacetone = CDP + dihydroxyacetone phosphate

641267, 641268

2.7.1.30

CTP + glycerol = CDP + glycerol 3-phosphate

641287, 641292, 641296, 641291, 641305, 641289, 641307

2.7.1.32

CTP + choline = CDP + choline phosphate

CTP + D-fructose = CDP + D-fructose 6-phosphate

641484, 640239, 641501, 641057, 641493, 641497, 641507, 641485, 640234, 641488, 662020, 661678, 663170

2.7.1.45

CTP + 2-dehydro-3-deoxy-D-gluconate = CDP + 6-phospho-2-dehydro-3-deoxy-D-gluconate

CTP + 5-hydroxy-2-methylpyrimidine = CDP + 2-methyl-5-phosphopyrimidine

641657

2.7.1.50

CTP + 4-methyl-5-(2-hydroxyethyl)thiazole = CDP + 4-methyl-5-(2-phosphonooxyethyl)thiazole

737878, 639720

2.7.1.52

CTP + 6-deoxy-L-galactose = CDP + 6-deoxy-L-galactose 1-phosphate

641671, 641670

2.7.1.54

CTP + D-arabinose = CDP + D-arabinose 5-phosphate

636978

2.7.1.56

CTP + D-fructose 1-phosphate = CDP + D-fructose 1,6-bisphosphate

640483, 641683, 727057

2.7.1.59

CTP + N-acetyl-D-glucosamine = CDP + N-acetyl-D-glucosamine 6-phosphate

641696

2.7.1.6

CTP + D-galactose = CDP + alpha-D-galactose 1-phosphate

CTP + myo-inositol = CDP + myo-inositol 1-phosphate

636605

2.7.1.67

CTP + 1-phosphatidyl-1D-myo-inositol = CDP + 1-phosphatidyl-1D-myo-inositol 4-phosphate

CTP + inosine = CDP + IMP

CTP + cellobiose = CDP + 6-phospho-beta-D-glucosyl-(1,4)-D-glucose

642059

2.7.1.86

CTP + NADH = CDP + NADPH

642062, 657853

2.7.1.B19

CTP + geranylgeraniol = CDP + geranylgeranyl phosphate

719754

2.7.1.B20

CTP + inosine = CDP + inosine 5'-phosphate

697882

2.7.11.31

CTP + [hydroxymethylglutaryl-CoA reductase (NADPH)] = CDP + [hydroxymethylglutaryl-CoA reductase (NADPH)] phosphate

644959

2.7.2.1

CTP + acetate = CDP + acetyl phosphate

642172, 642183, 642176, 642189, 642184, 487537, 642179, 721949, 727804, 730304

2.7.2.14

CTP + isobutanoate = CDP + isobutanoyl phosphate

642179

2.7.2.15

CTP + propanoate = CDP + propanoyl phosphate

CTP + formate = CDP + formyl phosphate

642342

2.7.4.10

CTP + AMP = CDP + ADP

642540, 662798, 642534

2.7.4.14

CTP + CMP = CDP + CDP

645161, 645143

2.7.4.15

CTP + thiamine diphosphate = CDP + thiamine triphosphate

645169

2.7.4.18

CTP + trans-farnesyl diphosphate = ?

645172

2.7.4.2

CTP + (R,S)-5-phosphomevalonate = CDP + (R,S)-5-diphosphomevalonate

663336

2.7.4.25

CTP + CMP = CDP + CDP

CTP + (2E,6E)-farnesyl phosphate = CDP + (2E,6E)-farnesyl diphosphate

CTP + dTMP = CDP + dTDP

645201, 645203, 645196, 645189, 645191, 645198

2.7.4.B1

CTP + UMP = CDP + UDP

663751

2.7.6.1

CTP + D-ribose 5-phosphate = CMP + 5-phospho-alpha-D-ribose 1-diphosphate

642716, 642729, 723571, 738194, 642738, 642710, 642735, 642711

2.7.6.2

CTP + thiamine = CMP + thiamine diphosphate

642753, 642743

2.7.6.4

dATP + CTP = dAMP + cytidine 3'-diphosphate 5'-triphosphate

645215

2.7.7.1

CTP + nicotinamide ribonucleotide = diphosphate + nicotinamide cytosine dinucleotide

661539

2.7.7.103

CTP + N5-phospho-L-glutamine = diphosphate + N5-(cytidine 5'-diphosphoramidyl)-L-glutamine

CTP + FMN = diphosphate + flavin cytidine dinucleotide

721625

2.7.7.23

CTP + N-acetyl-alpha-D-glucosamine 1-phosphate = diphosphate + CDP-N-acetyl-alpha-D-glucosamine

CTP + tobramycin = diphosphate + 2''-adenylyltobramycin

CTP + molybdenum cofactor = diphosphate + cytidylyl molybdenum cofactor

709036, 709163

2.7.7.8

RNA + CTP = RNA+1 + diphosphate

CTP + N,N'-diacetyllegionaminic acid = CMP-N,N'-diacetyllegionaminic acid + diphosphate

3 CTP = ?

CTP + 8-amino-3,8-dideoxy-alpha-D-manno-octulosonate = diphosphate + CMP-8-amino-3,8-dideoxy-alpha-D-manno-octulosonate

734255

2.7.7.91

CTP + valienol 1-phosphate = diphosphate + CDP-valienol

CTP + phosphonoformate = CMP-5'-phosphonoformate + diphosphate

CTP + H2O = CDP + phosphate

682302

3.1.3.9

glucose + CTP = glucose 6-phosphate + CDP

134941, 134945

3.1.4.16

CTP + H2O = CDP + phosphate

652555

3.1.4.37

CTP + H2O = CDP + phosphate

652555

3.5.2.14

CTP + dihydrouracil + H2O = ?

CTP + H2O = ?

CTP + H2O = UTP + NH3

CTP + H2O = ?

CTP + H2O = CMP + diphosphate

722230

3.6.1.15

CTP + H2O = CDP + phosphate

688347, 667694, 684774, 669274, 656663, 696153, 696275

3.6.1.28

CTP + H2O = CDP + phosphate

210008, 210020, 210007, 210017

3.6.1.3

CTP + H2O = CDP + phosphate

679612, 656663, 679609, 719750, 718685

CTP + H2O = ?

CTP + H2O = CMP + diphosphate

721477, 722102, 722623

3.6.1.8

CTP + H2O = CMP + diphosphate

CTP + H2O = CDP + phosphate

735052

3.6.4.12

CTP + H2O = CDP + phosphate

656166, 693900, 693688, 692155, 694418, 692262, 690795, 691019

3.6.4.13

CTP + H2O = CDP + phosphate

712760, 669138, 695264

3.6.4.B10

CTP + H2O = CDP + phosphate

728108

3.6.4.B6

CTP + H2O = CDP + phosphate

725893, 724227

4.1.1.33

CTP + 5-diphosphomevalonate = CDP + phosphate + isopentenyl diphosphate + CO2

4377, 4376, 650496

4.1.1.49

CTP + oxaloacetate = CDP + phosphoenolpyruvate + CO2

4636

4.6.1.2

CTP = 3',5'-cyclic CMP + diphosphate

729139

4.6.1.6

CTP = 3',5'-cyclic CMP + diphosphate

648784, 648787, 648788, 648789, 648790, 648791, 648792, 714199

5.6.1.2

CTP + H2O + a dynein associated with a microtubule at position n = CDP + phosphate + a dynein associated with a microtubule at position n-1 (toward the minus end)

247009, 247038, 247007

5.6.1.5

CTP + H2O + polypeptide = CDP + phosphate + unfolded polypeptide

210599, 210603, 210605, 751668

5.6.1.6

CTP + H2O + closed Cl- channel = CDP + phosphate + open Cl- channel

CTP + acetate + CoA = CMP + diphosphate + acetyl-CoA

574

6.2.1.12

CTP + ferulate + CoA = CMP + diphosphate + feruloyl-CoA

607

6.2.1.13

CTP + acetate + CoA = CDP + phosphate + acetyl-CoA

744820

6.2.1.2

CTP + butyrate + CoA = CMP + diphosphate + butyryl-CoA

677

6.2.1.22

CTP + acetate + citrate (pro-3S)-lyase = CMP + diphosphate + citrate(pro-3S)-lyase

697

6.2.1.24

CTP + phytanate + CoA = CMP + diphosphate + phytanoyl-CoA

702

6.2.1.26

CTP + o-succinylbenzoate + CoA = CMP + diphosphate + o-succinylbenzoyl-CoA

648943

6.2.1.27

CTP + 4-hydroxybenzoate + CoA = CMP + 4-hydroxybenzoyl-CoA + diphosphate

648909

6.2.1.30

CTP + phenylacetate + CoA = CMP + diphosphate + phenylacetyl-CoA

648914

6.2.1.36

3-hydroxypropanoate + CTP + coenzyme A = 3-hydroxypropanoyl-CoA + CMP + diphosphate

692841

6.2.1.8

CTP + oxalate + CoA = CMP + diphosphate + oxalyl-CoA

847

6.3.1.14

CTP + diphthine + ammonia = CDP + phosphate + diphthamide

1162

6.3.2.1

CTP + (R)-pantoate + beta-alanine = CMP + diphosphate + (R)-pantothenate

978

6.3.2.11

CTP + L-His + beta-Ala = CMP + phosphate + carnosine

997

6.3.2.16

CTP + D-Ala + membrane-acceptor = CDP + phosphate + D-alanyl-membrane acceptor

1056

6.3.2.17

CTP + 5,6,7,8-tetrahydropteroyl-Glu + Glu = CDP + phosphate + 5,6,7,8-tetrahydropteroyl-Glu2

1078, 1009

6.3.2.3

CTP + gamma-Glu-L-Cys + Gly = CDP + phosphate + glutathione

CTP + (R)-4'-phosphopantothenate + L-cysteine = CMP + diphosphate + N-[(R)-4'-phosphopantothenoyl]-L-cysteine

648958, 740570, 702454, 740672, 702284

6.3.3.2

CTP + 5-formyltetrahydrofolate = CDP + phosphate + 5,10-methylenetetrahydrofolate

1321, 1322, 1328, 1331

CTP + imidazoleacetic acid + 5-phosphoribosyl diphosphate = CDP + phosphate + 5'-phosphoribosylimidazoleacetate + diphosphate

1618

6.3.4.9

CTP + biotin + apo-[methylmalonyl-CoA:pyruvate carboxyltransferase] = CMP + diphosphate + [methylmalonyl-CoA:pyruvate carboxyltransferase]

1619

6.3.5.4

CTP + L-Asp + L-Gln = CMP + diphosphate + Asn + Glu

1702

6.5.1.1

ATP + CTP = P1-(5'-adenosyl),P4-(5'-cytidyl)tetraphosphate + diphosphate

722217

6.5.1.4

CTP + RNA 3'-terminal-phosphate = CMP + diphosphate + RNA terminal-2',3'-cyclic-phosphate

CTP + hydrogenobyrinic acid a,c-diamide + Co2+ = CDP + phosphate + cob(II)yrinic acid a,c-diamide + H+

653078

7.1.2.2

CTP + H2O + H+/in = CDP + phosphate + H+/out

210238, 210252, 210241

7.2.2.1

2 entries

7.2.2.10

CTP + H2O + Ca2+[side 1] = CDP + phosphate + Ca2+[side 2]

735233

7.2.2.19

CTP + H2O + H+/in + K+/out = CDP + phosphate + H+/out + K+/in

246851, 246853, 711012

7.2.2.3

CTP + H2O = ?

210276

7.3.2.1

CTP + H2O + phosphate/out = CDP + phosphate + phosphate/in

659162

7.4.2.1

CTP + H2O + His/out = CDP + phosphate + His/in

246888

7.4.2.5

CTP + H2O + peptide/out = CDP + phosphate + peptide/in

656145

7.6.2.11

spermidine/out + CTP + H2O = spermidine/in + CDP + phosphate

210316

7.6.2.2

2 entries

Product in Enzyme-catalyzed Reactions (105 results)

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2.7.1.26

CTP + riboflavin = CTP + riboflavin 5'-phosphate

2.7.1.40

CDP + phosphoenolpyruvate = CTP + pyruvate

2.7.3.8

CDP + phosphoramide = CTP + NH3

2.7.4.1

2 entries

2.7.4.25

ATP + CMP = ADP + CTP

diphosphate + CDP-glucose = CTP + alpha-D-glucose 1-phosphate

643748, 643751, 643752

3.6.1.29

Ap4C + H2O = AMP + CTP

6.2.1.13

CDP + phosphate + acetyl-CoA = CTP + acetate + CoA

CDP + phosphate + Na+/out = CTP + H2O + Na+/in

Enzyme Cofactor/Cosubstrate (32 results)

activation

enhances activity

about 40% activity compared to ATP

5% of the activity with ATP

less active than ATP

less active than ATP

low activity

642004, 642006, 642021, 642022

642256, 642266, 642268

2.7.6.1

can partially substitute for ATP

738194

2.7.7.89

activation by nucleotides, most efficient in presence of two different nucleotides

activation, maintains enzyme in its active conformation at pH 5 and above

Activator in Enzyme-catalyzed Reactions (98 results)

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1.1.1.189

at 1mM concentration slight stimulation

389477

1.1.1.405

marked stimulation, presence of 50 mM CTP decreases the Km value for ribulose 5-phosphate from 400 to 50 microM

645253

1.13.11.34

about half as active as ATP

10 mM, 340% arsenolytic cleavage activity

0.67 mM, 2.5fold stimulation

637870

2.7.1.113

activation, with ATP as substrate at pH 7

the activity of the enzyme reaches its maximal activity at a CTP concentration of about 1.4 mM. The maximal activity decreases by 68 and 95% when the concentration of CTP is 5.7 and 11.4 mM, respectively

activates

less effective than ATP

133998

3.1.2.1

counteracts the inhibition of the cold-labile cytosolic enzyme by ADP

94479

3.1.3.5

activation