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General Stability
Reference
2.8.3.5
An analysis of the three-dimensional structure of SCOT shows that the R268H mutation is expected to break a conserved salt bridge between R268 and D52, which would be expected to lead to decreased stability of the protein.
694193
2.8.3.5
degradation of 3-oxo acid CoA-transferase in glioma and neuroblastoma cells
645977
2.8.3.5
deoxycholate does not stabilize
645972
2.8.3.5
enzyme is only soluble under denaturating conditions
645991
2.8.3.5
enzyme is susceptible to proteolytic cleavage to produce a nicked but active enzyme, PMSF and EDTA protect
645971
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