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EC Number
Activating Compound
Commentary
Reference
6.2.1.1
2-mercaptoethanol
stimulates
574
6.2.1.1
acetate
required for ATP-diphosphate exchange
563
,
565
6.2.1.1
acetate
stimulates adenosine 5ยด-tetraphosphate synthesis
577
6.2.1.1
CobB Sir2 protein
activation of the acetylated enzyme requires the nicotinamide adenine dinucleotide-dependent protein deacetylase activity of the CobB Sir2 protein
653891
6.2.1.1
DTT
stimulates
574
6.2.1.1
GSH
stimulates
574
6.2.1.1
reduced ferredoxin
required
714240
6.2.1.1
SIR2 protein
short-chain fatty acid activation by acyl-coenzyme A synthetases requires SIR2 protein function
651427
6.2.1.1
SIRT1
AceCS1 is completely inactivated upon acetylation and is rapidly reactivated by SIRT3 deacetylation
676801
6.2.1.1
SIRT3
AceCS2 is completely inactivated upon acetylation and is rapidly reactivated by SIRT3 deacetylation
676801
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