EC Number   |
Activating Compound |
Reference |
|---|
   3.4.23.46 | 4-hydroxynonenal |
induction of BACE1 expression under oxidative stress determined |
683797 |
| 3.4.23.46 | bovine lung heparin |
0.0001 mg/ml increases BACE1 activity by 1600% |
712812 |
| 3.4.23.46 | etazolate |
i.e. 1-ethyl-4-(N'-isopropylidene-hydrazino)-1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid ethyl ester, stimulates alpha-secretase activity |
711929 |
| 3.4.23.46 | H2O2 |
induction of BACE1 expression under oxidative stress determined |
683797 |
| 3.4.23.46 | heparan sulfate |
0.0001 mg/ml increases BACE1 activity by 900% |
712812 |
| 3.4.23.46 | heparin |
heparin can increase the enzyme activity of the partially active zymogen proBACE1 |
712812 |
| 3.4.23.46 | heparin |
stimulates the partially active BACE1 zymogen. The activation is mediated by high-affinity binding of heparin to the pro-domain |
667730 |
| 3.4.23.46 | more |
BACE1 is increased by oxidative stress, oxidative stress fails to induce BACE1 expression in presenilin-1 (gamma-secretase)-deficient cells and in normal cells treated with gamma-secretase inhibitors, 4-hydroxy-2,3-nonenal enhances the expression of BACE1 in a gamma-secretase-dependent manner |
700411 |
| 3.4.23.46 | more |
heparin disaccharide does not stimulate proBACE1 activity at a concentration of 0.00001-0.1 mg/ml |
712812 |
| 3.4.23.46 | more |
in cells overexpressing amyloid precursor protein, thiamine deficiency promotes maturation of beta-site amyloid precursor protein cleaving enzyme 1, BACE1 and increases beta-secretase activity which results in elevated levels of beta-amyloid as well as beta-secretase cleaved C-terminal fragment. An inhibitor of beta-secretase efficiently reduces thiamine deficiency-induced up-regulation of amyloid beta and beta-secretase cleaved fragment. Thiamine supplementation reverses the thiamine deficiency-induced alterations. Thiamine deficiency treatment causes a significant accumulation of reactive oxygen species. Antioxidants suppress reactive oxygen species production and maturation of BACE1, as well as thiamine deficiency-induced amyloid beta accumulation. Exogenous amyloid beta1-40 enhances thiamine deficiency-induced production of reactive oxygen species |
700413 |
