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EC Number
Activating Compound
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2.3.1.B43
cardiolipin
SIRT5 electrostatically binds to cardiolipin, an N-terminal amphipathic helix mediates SIRT5 binding to cardiolipin, cardiolipin activates desuccinylation of membrane proteins
757175
2.3.1.B43
more
SIRT can be targeted by small molecules
756522
2.3.1.B43
more
SIRT can be targetted via small molecules
756522
2.3.1.B43
piceatannol
stimulates EC50: 0.07 mM
730713
2.3.1.B43
resveratrol
0.2 mM resveratrol can stimulate the Sirt5 deacetylase activity against the fluorophore-modified peptide substrate Fluor-de-Lys
730713
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