EC Number   |
Activating Compound |
Reference |
|---|
   1.4.1.3 | ADP |
activates at 1 mM |
688547 |
| 1.4.1.3 | ADP |
activates in presence of 3 M NaCl or 3 M KCl or in absence of salts |
655623 |
| 1.4.1.3 | ADP |
activation at 1 mM |
687565 |
| 1.4.1.3 | ADP |
activation is markedly diminished at lower pH values |
762783 |
| 1.4.1.3 | ADP |
activation only if concentrations of both NAD(P)+ and substrate are high |
391597 |
| 1.4.1.3 | ADP |
ADP activation is almost abolished after treatment with TLCK-treated chymotrypsin |
689913 |
| 1.4.1.3 | ADP |
ADP displays a lower affinity for hGDH2 than for hGDH1 |
700428 |
| 1.4.1.3 | ADP |
ADP induces an allosteric conformational change in GDH1, leading to a 2fold enhanced oxidative deamination |
699005 |
| 1.4.1.3 | ADP |
ADP is an activator of hGDH1 and hGDH2 which binds only to the open state |
763376 |
| 1.4.1.3 | ADP |
ADP is an activator of hGDH1 and hGDH2 which binds only to the open state. hGDH1mutant R443S/G456A exhibits a reduced ADP sensitivity compared both to hGDH1 and to hGDH2. The addition of the M415L and R470H mutations results in an even more pronounced drop in ADP affinity |
763376 |
