EC Number   |
Activating Compound |
Reference |
|---|
    1.14.16.1 | phenylalanine |
major regulator of liver enzyme, binds at an effector site converting the inactive to an active enzyme |
438715 |
| 1.14.16.1 | phenylalanine |
recombinant enzyme, 2fold increase in activity, cofactor tetrahydrobiopterin |
438742 |
| 1.14.16.1 | phenylalanine |
wild-type tetramer reveals a kinetic positive coorperativity of L-phenylalanine binding leading to a 5-6fold activation of wild-type tetramer, dimeric form shows a hyperbolic rate vs. substrate concentration, 1.6fold activation by phenylalanine, tetrameric T427P mutant enzyme shows no cooperativity, dimeric forms of wild-type and T427P mutant have similar kinetic properties |
438754 |
| 1.14.16.1 | Phospholipids |
activate |
438654, 438714, 438715, 438716, 438731 |
| 1.14.16.1 | Phospholipids |
increase in activity in the presence of tetrahydrobiopterin but not in the presence of synthetic pterin cofactors |
438731 |
| 1.14.16.1 | tetrahydrobiopterin |
excessive dosages of BH4 inhibit PAH under normal phenylalanine conditions in vivo and activate PAH under conditions of high phenylalanine, overview |
689019 |
| 1.14.16.1 | Trypsin |
limited proteolysis of purified liver enzyme |
438731 |
