Gene ontology ID
GO:0120123
Definition
A protein complex responsible for the catalysis of the reaction: E1 + ubiquitin + ATP--> E1-ubiquitin + AMP + PPi, where the E1-ubiquitin linkage is a thioester bond between the C-terminal glycine of Ub and a sulfhydryl side group of an E1 cysteine residue. This is the first step in a cascade of reactions in which ubiquitin is ultimately added to a protein substrate
Synonyms
1. E1 complex
2. E1 ubiquitin-activating enzyme
References
1. GOC: lnp
2. PMID 95452343. IntAct: EBI-16629455
Legend
![](./ontology/inc/tree/images/is_a.png)
is an element of the parent element
![](./ontology/inc/tree/images/part_of.png)
is a part of the parent element
![](./ontology/inc/tree/images/rel.png)
is related to the parent element
![](./ontology/inc/tree/images/der.png)
derives from the parent element
![](./ontology/inc/tree/images/tissue_branch.png)
/
![](./ontology/inc/tree/images/brenda_branch.png)
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![](./ontology/inc/tree/images/localization_branch.png)
at least 1 tissue/ enzyme/ localization link in this branch
![](./ontology/inc/tree/images/tissue.png)
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![](./ontology/inc/tree/images/brenda.png)
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![](./ontology/inc/tree/images/localization.png)
tissue/ enzyme/ localization link to BRENDA