Gene ontology ID
GO:0106002
Definition
A protein complex that binds to, and promotes stabilization of, mRNA molecules containing the major coding region instability determinant (mCRD) by bridging the mCRD domain and the poly(A) tail of the mRNA. In human, it consists of CSDE1, HNRPD, PABPC1, PAIP1 and SYNCRIP
Comment
This complex is related to GO:0070937 CRD-mediated mRNA stability complex but binds the major protein-coding-region determinant of instability (mCRD) domain rather than the CRD. Experimentally it has been shown to act on c-FOS mRNA while GO:0070937 acts on c-MYC mRNA.
Synonyms
1. major coding region determinant of instability-mediated mRNA stability complex
2. major coding region instability determinant-mediated mRNA stability complex
3. major coding region instability determinant-poly(A)-bridging complex
4. major coding-region determinant of instability - poly(A) tail-bridging complex
5. mCRD-poly(A)-bridging complex
References
1. GOC: bhm
2. PMID 110515453. IntAct: EBI-13948957
Legend
is an element of the parent element
is a part of the parent element
is related to the parent element
derives from the parent element
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at least 1 tissue/ enzyme/ localization link in this branch
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tissue/ enzyme/ localization link to BRENDA