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Gene ontology
Version 2014-12-22
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Details for glycine hydroxymethyltransferase activity
2.1.2.1
Gene ontology ID
GO:0004372
Definition
Catalysis of the reaction: 5,10-methylenetetrahydrofolate + glycine + H2O = tetrahydrofolate + L-serine
Synonyms
1. 5,10-methylenetetrahydrofolate:glycine hydroxymethyltransferase activity
2. allothreonine aldolase activity
3. L-serine hydroxymethyltransferase activity
4. serine aldolase activity
5. serine hydroxymethylase activity
6. serine hydroxymethyltransferase activity
7. serine transhydroxymethylase activity
References
1. EC 2.1.2.1
2. MetaCyc GLYOHMETRANS-RXN
3. Reactome: R-HSA-200651 "5,10-methyleneTHF polyglutamate + glycine <=> tetrahydrofolate polyglutamate (THF polyglutamate) + serine"
4. Reactome: R-HSA-200735 "Tetrahydrofolate polyglutamate (THF polyglutamate) + serine <=> 5,10-methyleneTHF polyglutamate + glycine"
5. Reactome: R-HSA-5694137 "SHMT2 tetramer transfers CH2OH group from 5,10MTHF to glycine"
6. Reactome: R-HSA-71249 "SHMT1 tetramer cleaves HTMLYS to yield TEABL and Gly"
7. RHEA: 15481
Legend
is an element of the parent element
is a part of the parent element
is related to the parent element
derives from the parent element
// at least 1 tissue/ enzyme/ localization link in this branch
// tissue/ enzyme/ localization link to BRENDA
Condensed Tree View
Gene ontology
molecular_function is a
catalytic activity is a
transferase activity is a
transferase activity, transferring one-carbon groups is a
hydroxymethyl-, formyl- and related transferase activity is a
glycine hydroxymethyltransferase activity is a
Tree view
Gene ontology
biological_process is a
cellular_component is a
molecular_function is a
binding is a
catalytic activity is a
catalytic activity, acting on a protein is a
catalytic activity, acting on DNA is a
catalytic activity, acting on RNA is a
cyclase activity is a
hydrolase activity is a
isomerase activity is a
ligase activity is a
lyase activity is a
peptidoglycan muralytic activity is a
transferase activity is a
Atg8 ligase activity is a
CDP-alcohol phosphotransferase activity is a
glucanosyltransferase activity is a
Kdo transferase activity is a
mannosylphosphate transferase activity is a
molybdopterin molybdotransferase activity is a
transferase activity, transferring acyl groups is a
transferase activity, transferring aldehyde or ketonic groups is a
transferase activity, transferring alkyl or aryl (other than methyl) groups is a
transferase activity, transferring glycosyl groups is a
transferase activity, transferring nitrogenous groups is a
transferase activity, transferring one-carbon groups is a
carboxyl- or carbamoyltransferase activity is a
hydroxymethyl-, formyl- and related transferase activity is a
3-methyl-2-oxobutanoate hydroxymethyltransferase activity is a
D-alanine 2-hydroxymethyltransferase activity is a
deoxycytidylate 5-hydroxymethyltransferase activity is a
formimidoyltransferase activity is a
glycine hydroxymethyltransferase activity is a
phosphoribosylaminoimidazolecarboxamide formyltransferase activity is a
phosphoribosylglycinamide formyltransferase 2 activity is a
phosphoribosylglycinamide formyltransferase activity is a
tetrahydromethanopterin-dependent serine hydroxymethyltransferase activity is a
UDP-4-amino-4-deoxy-L-arabinose formyltransferase activity is a
methyltransferase activity is a
transferase activity, transferring phosphorus-containing groups is a
transferase activity, transferring selenium-containing groups is a
transferase activity, transferring sulfur-containing groups is a
UDP-L-rhamnose synthase activity is a
molecular transducer activity is a
nutrient reservoir activity is a
protein tag is a
small molecule sensor activity is a
structural molecule activity is a
transcription regulator activity is a
transporter activity is a