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Gene ontology
Version 2014-12-22
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Details for leukocyte tethering or rolling
Gene ontology ID
GO:0050901
Definition
Transient adhesive interactions between leukocytes and endothelial cells lining blood vessels. Carbohydrates on circulating leukocytes bind selectins on the vessel wall causing the leukocytes to slow down and roll along the inner surface of the vessel wall. During this rolling motion, transitory bonds are formed and broken between selectins and their ligands. Typically the first step in cellular extravasation (the movement of leukocytes out of the circulatory system, towards the site of tissue damage or infection)
References
1. GOC: bf
2. ISBN 0781735149
3. PMID 14680625
4. PMID 14708592
5. PMID 7507411
6. PMID 8600538
7. Wikipedia: Leukocyte extravasation
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