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Literature summary for 7.4.2.8 extracted from
- Type II protein secretion is a subset of the PilD-dependent processes that facilitate intracellular infection by Legionella pneumophila (2001), Infect. Immun., 69, 2092-2098.
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | pilD-dependent mechanism for promoting Legionella pneumophila intracellular infection of human cells | Legionella pneumophila |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| additional information | gene disruption mutant, shows reduced secretion of pilD-dependent enzymatic activities, mutants are greatly impaired for growth within Hartmannella vermiformis. Upon infection of U937 macrophages, mutant strains exhibit a 10fold reduction in intracellular multiplication and a diminished cytopathic effect | Legionella pneumophila |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Legionella pneumophila | Q9AGM7 | - |
- |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| lspDE | - |
Legionella pneumophila |
| type II outer membrane secretin | - |
Legionella pneumophila |
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Release 2023.1 (January 2023)
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