Literature summary for 7.4.2.8 extracted from

Kubori, T.; Matsushima, Y.; Nakamura, D.; Uralil, J.; Lara-Tejero, M.; Sukhan, A.; Galan, J.E.; Aizawa, S.I.
Supramolecular structure of the Salmonella typhimurium type III protein secretion system (1998), Science, 280, 602-605.

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Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
ATP + H2O	Salmonella enterica subsp. enterica serovar Typhimurium	type III protein-secretion system delivers bacterial proteins into host cells that mediate this bacterium´s ability to enter nonpathogenic cells	ADP + phosphate	-	?
ATP + H2O	Salmonella enterica subsp. enterica serovar Typhimurium SJW2941	type III protein-secretion system delivers bacterial proteins into host cells that mediate this bacterium´s ability to enter nonpathogenic cells	ADP + phosphate	-	?

Organism

Organism	UniProt	Comment	Textmining
Salmonella enterica subsp. enterica serovar Typhimurium	-	-	-
Salmonella enterica subsp. enterica serovar Typhimurium SJW2941	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + H2O	type III protein-secretion system delivers bacterial proteins into host cells that mediate this bacterium´s ability to enter nonpathogenic cells	Salmonella enterica subsp. enterica serovar Typhimurium	ADP + phosphate	-	?
ATP + H2O	type III protein-secretion system delivers bacterial proteins into host cells that mediate this bacterium´s ability to enter nonpathogenic cells	Salmonella enterica subsp. enterica serovar Typhimurium SJW2941	ADP + phosphate	-	?

Subunits

Subunits	Comment	Organism
More	several components of the type III secretion system are organized in a supramolecular structure termed needle complex. This structure is made of discrete structures including a base that spans both membranes and a needle-like projection that extends outwards from the bacterial surface. The type III secretion export apparatus is required for the assembly of the needle substructure but is dispensable for the assembly of the base. The length of the needle segment is determined by the type III secretion associated protein InvJ. InvG, PrgH, and PrgK constitute the base. PrgI is the main component of the needle of the type III secretion complex. The needle component may establish the specificity of type III secretion system in delivering proteins into either plant or animal cells	Salmonella enterica subsp. enterica serovar Typhimurium

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Release 2023.1 (January 2023)