Application | Comment | Organism |
---|---|---|
drug development | GlnA1 may not be a suitable target to find anti-tubercular drugs | Mycobacterium tuberculosis |
Crystallization (Comment) | Organism |
---|---|
enzyme complexed with 3, X-ray diffraction structure determination and analysis | Mycobacterium tuberculosis |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(2S)-2-amino-4-(S-methanesulfonimidoyl)butanoic acid | - |
Mycobacterium tuberculosis | |
4-[2-tert-butyl-4-(6-methoxynaphthalen-2-yl)-1H-imidazol-5-yl]pyridin-2-amine | - |
Mycobacterium tuberculosis | |
5-(2-methoxyethyl)-9-phenyl-5,10-dihydro-4H-imidazo[1,2-a]indeno[1,2-e]pyrazin-4-one | - |
Mycobacterium tuberculosis | |
5-(3-methylbutyl)-9-(pyridin-3-yl)-5,10-dihydro-4H-imidazo[1,2-a]indeno[1,2-e]pyrazin-4-one | - |
Mycobacterium tuberculosis | |
5-(but-3-en-1-yl)-9-(pyridin-3-yl)-5,10-dihydro-4H-imidazo[1,2-a]indeno[1,2-e]pyrazin-4-one | - |
Mycobacterium tuberculosis | |
5-benzyl-9-phenyl-5,10-dihydro-4H-imidazo[1,2-a]indeno[1,2-e]pyrazin-4-one | - |
Mycobacterium tuberculosis | |
5-cyclopropyl-9-(pyridin-2-yl)-5,10-dihydro-4H-imidazo[1,2-a]indeno[1,2-e]pyrazin-4-one | - |
Mycobacterium tuberculosis | |
5-methyl-9-phenyl-5,10-dihydro-4H-imidazo[1,2-a]indeno[1,2-e]pyrazin-4-one | - |
Mycobacterium tuberculosis | |
5-[3-(dimethylamino)propyl]-9-(3-methoxyphenyl)-5,10-dihydro-4H-imidazo[1,2-a]indeno[1,2-e]pyrazin-4-one | - |
Mycobacterium tuberculosis | |
5-[3-(dimethylamino)propyl]-9-(pyridin-2-yl)-5,10-dihydro-4H-imidazo[1,2-a]indeno[1,2-e]pyrazin-4-one | - |
Mycobacterium tuberculosis | |
5-[3-(dimethylamino)propyl]-9-(pyridin-3-yl)-5,10-dihydro-4H-imidazo[1,2-a]indeno[1,2-e]pyrazin-4-one | - |
Mycobacterium tuberculosis | |
9-(3-chlorophenyl)-5,10-dihydro-4H-imidazo[1,2-a]indeno[1,2-e]pyrazin-4-one | - |
Mycobacterium tuberculosis | |
9-(3-methoxyphenyl)-5,10-dihydro-4H-imidazo[1,2-a]indeno[1,2-e]pyrazin-4-one | - |
Mycobacterium tuberculosis | |
9-(pyridin-3-yl)-5,10-dihydro-4H-imidazo[1,2-a]indeno[1,2-e]pyrazin-4-one | - |
Mycobacterium tuberculosis | |
9-(quinolin-5-yl)-5,10-dihydro-4H-imidazo[1,2-a]indeno[1,2-e]pyrazin-4-one | - |
Mycobacterium tuberculosis | |
9-bromo-5,10-dihydro-4H-imidazo[1,2-a]indeno[1,2-e]pyrazin-4-one | - |
Mycobacterium tuberculosis | |
9-phenyl-5,10-dihydro-4H-imidazo[1,2-a]indeno[1,2-e]pyrazin-4-one | - |
Mycobacterium tuberculosis | |
9-phenyl-5-(prop-2-en-1-yl)-5,10-dihydro-4H-imidazo[1,2-a]indeno[1,2-e]pyrazin-4-one | - |
Mycobacterium tuberculosis | |
additional information | high throughput screening of series of imidazo[1,2-a]indeno[1,2-e]pyrazin-4-ones as enzyme inhibitors, overview. None of these compounds is active on whole cell Mycobacterium tuberculosis. Structure activity relationships of 5,10-dihydro-imidazo[1,2-a]indeno[1,2-e]pyrazin-4-one derivatives | Mycobacterium tuberculosis | |
N-(4-oxo-5,10-dihydro-4H-imidazo[1,2-a]indeno[1,2-e]pyrazin-9-yl)acetamide | - |
Mycobacterium tuberculosis |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | required | Mycobacterium tuberculosis |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + L-glutamate + NH3 | Mycobacterium tuberculosis | - |
ADP + phosphate + L-glutamine | - |
r | |
ATP + L-glutamate + NH3 | Mycobacterium tuberculosis ATCC 25618 / H37Rv | - |
ADP + phosphate + L-glutamine | - |
r |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mycobacterium tuberculosis | P9WN39 | - |
- |
Mycobacterium tuberculosis ATCC 25618 / H37Rv | P9WN39 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + L-glutamate + NH3 | - |
Mycobacterium tuberculosis | ADP + phosphate + L-glutamine | - |
r | |
ATP + L-glutamate + NH3 | - |
Mycobacterium tuberculosis ATCC 25618 / H37Rv | ADP + phosphate + L-glutamine | - |
r |
Subunits | Comment | Organism |
---|---|---|
dodecamer | Mtb-GlnA1 crystallizes in the space group P212121 with 24 monomers in the asymmetric unit to form a dodecamer. The 24 active sites of the dodecamer are found in long grooves between the subunits | Mycobacterium tuberculosis |
Synonyms | Comment | Organism |
---|---|---|
GlnA1 | - |
Mycobacterium tuberculosis |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Mycobacterium tuberculosis |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
additional information | - |
IC50 values of the compounds versus Mycobacterium tuberculosis cells and human Hep-G2 cells | Mycobacterium tuberculosis | additional information | |
0.000007 | - |
pH and temperature not specified in the publication | Mycobacterium tuberculosis | 5-(but-3-en-1-yl)-9-(pyridin-3-yl)-5,10-dihydro-4H-imidazo[1,2-a]indeno[1,2-e]pyrazin-4-one | |
0.00003 | - |
pH and temperature not specified in the publication | Mycobacterium tuberculosis | 9-bromo-5,10-dihydro-4H-imidazo[1,2-a]indeno[1,2-e]pyrazin-4-one | |
0.000031 | - |
pH and temperature not specified in the publication | Mycobacterium tuberculosis | 9-(pyridin-3-yl)-5,10-dihydro-4H-imidazo[1,2-a]indeno[1,2-e]pyrazin-4-one | |
0.000031 | - |
pH and temperature not specified in the publication | Mycobacterium tuberculosis | 9-phenyl-5,10-dihydro-4H-imidazo[1,2-a]indeno[1,2-e]pyrazin-4-one | |
0.000051 | - |
pH and temperature not specified in the publication | Mycobacterium tuberculosis | 9-(3-methoxyphenyl)-5,10-dihydro-4H-imidazo[1,2-a]indeno[1,2-e]pyrazin-4-one | |
0.000066 | - |
pH and temperature not specified in the publication | Mycobacterium tuberculosis | 5-(3-methylbutyl)-9-(pyridin-3-yl)-5,10-dihydro-4H-imidazo[1,2-a]indeno[1,2-e]pyrazin-4-one | |
0.000084 | - |
pH and temperature not specified in the publication | Mycobacterium tuberculosis | 5-[3-(dimethylamino)propyl]-9-(3-methoxyphenyl)-5,10-dihydro-4H-imidazo[1,2-a]indeno[1,2-e]pyrazin-4-one | |
0.000131 | - |
pH and temperature not specified in the publication | Mycobacterium tuberculosis | 5-[3-(dimethylamino)propyl]-9-(pyridin-3-yl)-5,10-dihydro-4H-imidazo[1,2-a]indeno[1,2-e]pyrazin-4-one | |
0.00017 | - |
pH and temperature not specified in the publication | Mycobacterium tuberculosis | 5-methyl-9-phenyl-5,10-dihydro-4H-imidazo[1,2-a]indeno[1,2-e]pyrazin-4-one | |
0.000219 | - |
pH and temperature not specified in the publication | Mycobacterium tuberculosis | 5-(2-methoxyethyl)-9-phenyl-5,10-dihydro-4H-imidazo[1,2-a]indeno[1,2-e]pyrazin-4-one | |
0.000333 | - |
pH and temperature not specified in the publication | Mycobacterium tuberculosis | 9-phenyl-5-(prop-2-en-1-yl)-5,10-dihydro-4H-imidazo[1,2-a]indeno[1,2-e]pyrazin-4-one | |
0.000456 | - |
pH and temperature not specified in the publication | Mycobacterium tuberculosis | 5-cyclopropyl-9-(pyridin-2-yl)-5,10-dihydro-4H-imidazo[1,2-a]indeno[1,2-e]pyrazin-4-one | |
0.00061 | - |
pH and temperature not specified in the publication | Mycobacterium tuberculosis | 9-(3-chlorophenyl)-5,10-dihydro-4H-imidazo[1,2-a]indeno[1,2-e]pyrazin-4-one | |
0.000663 | - |
pH and temperature not specified in the publication | Mycobacterium tuberculosis | 5-benzyl-9-phenyl-5,10-dihydro-4H-imidazo[1,2-a]indeno[1,2-e]pyrazin-4-one | |
0.000857 | - |
pH and temperature not specified in the publication | Mycobacterium tuberculosis | 5-[3-(dimethylamino)propyl]-9-(pyridin-2-yl)-5,10-dihydro-4H-imidazo[1,2-a]indeno[1,2-e]pyrazin-4-one | |
0.0021 | - |
pH and temperature not specified in the publication | Mycobacterium tuberculosis | N-(4-oxo-5,10-dihydro-4H-imidazo[1,2-a]indeno[1,2-e]pyrazin-9-yl)acetamide | |
0.007 | - |
pH and temperature not specified in the publication | Mycobacterium tuberculosis | 9-(quinolin-5-yl)-5,10-dihydro-4H-imidazo[1,2-a]indeno[1,2-e]pyrazin-4-one |
General Information | Comment | Organism |
---|---|---|
metabolism | the enzyme catalyzes the ATP-dependent synthesis of L-glutamine from glutamate and ammonia. GlnA1 is also involved in the synthesis of poly-L-glutamate/glutamine for the cell wall of pathogenic mycobacteria | Mycobacterium tuberculosis |
physiological function | the enzyme catalyzes the ATP-dependent synthesis of L-glutamine from glutamate and ammonia. GlnA1 is also involved in the synthesis of poly-L-glutamate/glutamine for the cell wall of pathogenic mycobacteria | Mycobacterium tuberculosis |