BRENDA - Enzyme Database show
show all sequences of 6.2.1.7

Identification of bile acid coenzyme A synthetase in rat kidney

Kwakye, J.B.; Barnes, S.; Diasio, R.B.; J. Lipid Res. 34, 95-99 (1993)

Data extracted from this reference:

Inhibitors
Inhibitors
Commentary
Organism
Structure
EDTA
-
Rattus norvegicus
Metals/Ions
Metals/Ions
Commentary
Organism
Structure
Mg2+
stimulates up to a maximal concentration of 5 mM
Rattus norvegicus
Natural Substrates/ Products (Substrates)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
ATP + cholate + CoA
Rattus norvegicus
kidney has the potential for bile acid metabolism and may have a role in bile acid physiology. Conjugation of bile acids in the kidney may serve as a protective mechanism by which the renal cell avoids injury from circulating unconjugated bile acids
?
-
-
-
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Rattus norvegicus
-
-
-
Source Tissue
Source Tissue
Commentary
Organism
Textmining
kidney
-
Rattus norvegicus
-
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
ATP + chenodeoxycholate + CoA
-
834
Rattus norvegicus
AMP + diphosphate + chenodeoxycholoyl-CoA
-
834
Rattus norvegicus
-
ATP + cholate + CoA
kidney has the potential for bile acid metabolism and may have a role in bile acid physiology. Conjugation of bile acids in the kidney may serve as a protective mechanism by which the renal cell avoids injury from circulating unconjugated bile acids
834
Rattus norvegicus
?
-
-
-
-
pH Optimum
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
8.5
-
-
Rattus norvegicus
pH Range
pH Minimum
pH Maximum
Commentary
Organism
6.5
9.8
6.5: about 30% of maximal activity, 9.8: about 50% of maximal activity
Rattus norvegicus
Inhibitors (protein specific)
Inhibitors
Commentary
Organism
Structure
EDTA
-
Rattus norvegicus
Metals/Ions (protein specific)
Metals/Ions
Commentary
Organism
Structure
Mg2+
stimulates up to a maximal concentration of 5 mM
Rattus norvegicus
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
ATP + cholate + CoA
Rattus norvegicus
kidney has the potential for bile acid metabolism and may have a role in bile acid physiology. Conjugation of bile acids in the kidney may serve as a protective mechanism by which the renal cell avoids injury from circulating unconjugated bile acids
?
-
-
-
Source Tissue (protein specific)
Source Tissue
Commentary
Organism
Textmining
kidney
-
Rattus norvegicus
-
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
ATP + chenodeoxycholate + CoA
-
834
Rattus norvegicus
AMP + diphosphate + chenodeoxycholoyl-CoA
-
834
Rattus norvegicus
-
ATP + cholate + CoA
kidney has the potential for bile acid metabolism and may have a role in bile acid physiology. Conjugation of bile acids in the kidney may serve as a protective mechanism by which the renal cell avoids injury from circulating unconjugated bile acids
834
Rattus norvegicus
?
-
-
-
-
pH Optimum (protein specific)
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
8.5
-
-
Rattus norvegicus
pH Range (protein specific)
pH Minimum
pH Maximum
Commentary
Organism
6.5
9.8
6.5: about 30% of maximal activity, 9.8: about 50% of maximal activity
Rattus norvegicus
Other publictions for EC 6.2.1.7
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
728839
Hadzic
Diagnosis in bile acid-CoA: am ...
Homo sapiens
World J. Gastroenterol.
18
3322-3326
2012
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1
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1
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-
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-
-
2
2
-
-
-
662588
Falany
Molecular cloning and expressi ...
Rattus norvegicus
J. Lipid Res.
43
2062-2071
2002
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-
1
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-
9
2
1
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1
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1
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1
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1
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9
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2
1
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1
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1
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-
651997
Steinberg
The human liver-specific homol ...
Homo sapiens
J. Biol. Chem.
275
15605-15608
2000
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-
1
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1
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1
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2
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1
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1
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3
-
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-
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-
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660788
Wheeler
Purification and characterizat ...
Rattus norvegicus
Arch. Biochem. Biophys.
348
15-24
1997
-
-
-
-
-
-
4
2
1
1
2
-
-
2
-
-
1
-
-
3
1
-
1
1
-
-
-
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
4
-
2
1
1
2
-
-
-
-
1
-
3
1
-
1
1
-
-
-
-
1
1
-
-
-
-
-
-
-
-
833
Van Veldhoven
Stabilisation and partial puri ...
Rattus norvegicus
Biochem. Mol. Biol. Int.
40
447-457
1996
1
-
-
-
-
2
-
-
1
-
1
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-
2
-
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-
2
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2
1
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1
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-
2
-
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1
-
1
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-
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-
2
-
2
1
-
-
-
-
-
-
-
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-
-
-
-
-
-
-
831
Kelley
Determination of the mechanism ...
Cavia porcellus
Biochem. J.
304
945-949
1994
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-
-
-
-
-
2
-
1
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-
1
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1
-
1
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1
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-
-
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-
-
-
-
2
-
-
1
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-
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-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
835
Kelley
Dual role of divalent cations ...
Cavia porcellus
Biochim. Biophys. Acta
1209
51-55
1994
-
-
-
-
-
-
1
-
1
2
-
-
-
2
-
-
-
-
-
3
-
-
1
-
-
-
-
-
-
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-
-
-
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-
-
1
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-
1
2
-
-
-
-
-
-
-
3
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
834
Kwakye
Identification of bile acid co ...
Rattus norvegicus
J. Lipid Res.
34
95-99
1993
-
-
-
-
-
-
1
-
-
1
-
1
-
3
-
-
-
-
-
3
-
-
2
-
-
-
-
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
1
-
1
-
-
-
-
-
3
-
-
2
-
-
-
-
-
1
1
-
-
-
-
-
-
-
-
836
Vessey
Chemical modification of bile ...
Cavia porcellus
Biochim. Biophys. Acta
1203
126-130
1993
1
-
-
-
-
-
3
-
1
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-
-
-
1
-
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-
1
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1
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1
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3
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1
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1
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1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
648913
Östlund
Human hepatoblastoma cells (He ...
no activity in Homo sapiens, Rattus norvegicus
J. Lipid Res.
34
2041-2050
1993
-
-
-
-
-
-
1
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2
-
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1
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1
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1
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1
-
-
1
-
-
-
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-
-
-
-
-
-
-
-
-
-
-
830
Mallonee
The bile acid-inducible baiB g ...
Eubacterium sp., Eubacterium sp. VPI 12708
J. Bacteriol.
174
2065-2071
1992
-
-
1
-
-
-
-
2
-
1
1
2
-
14
-
-
-
-
-
1
-
-
10
1
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-
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-
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-
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-
1
-
-
-
-
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-
2
-
1
1
2
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-
1
-
-
10
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
837
Vessey
A coupled assay for bile acid: ...
Cavia porcellus
Anal. Biochem.
195
97-100
1991
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1
-
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-
-
-
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1
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1
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1
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1
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1
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1
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1
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1
-
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-
-
-
-
-
-
-
-
-
-
-
-
829
Vessey
Purification and characterizat ...
Ophiodon elongatus, Sebastes miniatus, Sebastes pinniger
Comp. Biochem. Physiol. B
95
647-652
1990
-
-
-
-
-
-
-
4
3
-
-
-
-
3
-
-
1
-
-
3
1
-
6
1
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-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
4
3
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-
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-
-
-
1
-
3
1
-
6
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
844
Mallonee
-
Cloning and sequencing of a bi ...
Eubacterium sp., Eubacterium sp. VPI 12708
J. Bacteriol.
172
7001-7019
1990
-
-
1
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-
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-
-
-
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-
12
-
-
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1
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-
832
Schepers
Subcellular distribution and c ...
Rattus norvegicus
Biochem. J.
257
221-229
1989
-
-
-
-
-
-
2
1
1
-
-
-
-
2
-
-
-
-
-
4
-
-
1
-
-
-
-
-
-
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-
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2
-
1
1
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4
-
-
1
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-
-
-
729
Prydz
Subcellular localization of 3a ...
Rattus norvegicus
J. Lipid Res.
29
997-1004
1988
3
-
-
-
-
-
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-
1
1
-
1
-
1
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-
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-
-
1
1
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1
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1
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3
-
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1
1
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1
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1
1
-
1
-
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-
-
1
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-
-
-
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-
-
-
-
838
Simion
Subcellular distribution of ch ...
Rattus norvegicus
Biochemistry
22
5029-5034
1983
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1
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-
2
-
1
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2
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3
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1
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1
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2
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1
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3
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1
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-
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-
-
-
-
-
-
-
839
Lim
Subcellular distribution of he ...
Rattus norvegicus
Biochem. J.
197
611-618
1981
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1
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1
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1
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1
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1
-
-
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-
840
Kirkpatrick
Diurnal variation of rat liver ...
Rattus norvegicus
Biochim. Biophys. Acta
620
627-630
1980
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-
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-
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1
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1
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1
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1
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1
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-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
841
Polokoff
Evidence that cholic acid CoA ...
Rattus norvegicus
J. Lipid Res.
20
17-21
1979
-
-
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1
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1
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1
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1
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1
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-
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-
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-
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-
-
-
842
Vessey
Characterization of microsomal ...
Cavia porcellus
Biochem. J.
163
357-362
1977
-
-
-
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4
3
1
4
-
-
-
1
-
-
-
-
-
1
-
-
1
-
-
-
-
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
4
-
3
1
4
-
-
-
-
-
-
-
1
-
-
1
-
-
-
-
-
1
1
-
-
-
-
-
-
-
-
843
Polokoff
Characterization of liver chol ...
Rattus norvegicus
J. Biol. Chem.
252
1167-1171
1977
-
-
-
-
-
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-
1
1
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1
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1
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2
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-
1
-
1
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1
1
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1
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2
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1
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1
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