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ATP + 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanate + CoA
AMP + diphosphate + 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoyl-CoA
ATP + chenodeoxycholate + CoA
AMP + diphosphate + chenodeoxycholoyl-CoA
ATP + cholate + CoA
AMP + diphosphate + choloyl-CoA
ATP + deoxycholate + CoA
AMP + diphosphate + deoxycholoyl-CoA
ATP + lithocholate + CoA
AMP + diphosphate + lithocholoyl-CoA
-
-
-
-
?
dATP + cholate + CoA
dAMP + diphosphate + choloyl-CoA
-
-
-
-
?
additional information
?
-
ATP + 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanate + CoA
AMP + diphosphate + 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoyl-CoA
-
-
-
?
ATP + 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanate + CoA
AMP + diphosphate + 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoyl-CoA
-
-
-
?
ATP + chenodeoxycholate + CoA
AMP + diphosphate + chenodeoxycholoyl-CoA
-
-
-
-
?
ATP + chenodeoxycholate + CoA
AMP + diphosphate + chenodeoxycholoyl-CoA
-
-
-
-
?
ATP + chenodeoxycholate + CoA
AMP + diphosphate + chenodeoxycholoyl-CoA
-
-
-
-
?
ATP + chenodeoxycholate + CoA
AMP + diphosphate + chenodeoxycholoyl-CoA
-
-
-
?
ATP + chenodeoxycholate + CoA
AMP + diphosphate + chenodeoxycholoyl-CoA
-
-
-
-
?
ATP + cholate + CoA
AMP + diphosphate + choloyl-CoA
-
-
-
-
?
ATP + cholate + CoA
AMP + diphosphate + choloyl-CoA
-
-
-
?
ATP + cholate + CoA
AMP + diphosphate + choloyl-CoA
-
-
-
?
ATP + cholate + CoA
AMP + diphosphate + choloyl-CoA
-
-
-
?
ATP + cholate + CoA
AMP + diphosphate + choloyl-CoA
-
-
-
-
?
ATP + cholate + CoA
AMP + diphosphate + choloyl-CoA
-
-
-
?
ATP + cholate + CoA
AMP + diphosphate + choloyl-CoA
-
initial step in the bile acid 7alpha-dehydroxylation pathway
-
-
?
ATP + cholate + CoA
AMP + diphosphate + choloyl-CoA
-
-
-
?
ATP + cholate + CoA
AMP + diphosphate + choloyl-CoA
-
initial step in the bile acid 7alpha-dehydroxylation pathway
-
-
?
ATP + cholate + CoA
AMP + diphosphate + choloyl-CoA
-
-
-
?
ATP + cholate + CoA
AMP + diphosphate + choloyl-CoA
-
re-activation and re-conjugation of bile acids
-
?
ATP + cholate + CoA
AMP + diphosphate + choloyl-CoA
-
-
-
?
ATP + cholate + CoA
AMP + diphosphate + choloyl-CoA
-
-
-
-
?
ATP + cholate + CoA
AMP + diphosphate + choloyl-CoA
-
-
-
?
ATP + cholate + CoA
AMP + diphosphate + choloyl-CoA
-
-
-
-
?
ATP + cholate + CoA
AMP + diphosphate + choloyl-CoA
-
kidney has the potential for bile acid metabolism and may have a role in bile acid physiology. Conjugation of bile acids in the kidney may serve as a protective mechanism by which the renal cell avoids injury from circulating unconjugated bile acids
-
-
?
ATP + cholate + CoA
AMP + diphosphate + choloyl-CoA
-
choloyl-CoA synthetase is probably the rate limiting enzyme in the two-enzyme sequence catalyzing conjugation of bile acids
-
-
?
ATP + cholate + CoA
AMP + diphosphate + choloyl-CoA
-
-
-
?
ATP + cholate + CoA
AMP + diphosphate + choloyl-CoA
-
-
-
?
ATP + deoxycholate + CoA
AMP + diphosphate + deoxycholoyl-CoA
-
-
-
-
?
ATP + deoxycholate + CoA
AMP + diphosphate + deoxycholoyl-CoA
-
-
-
-
?
ATP + deoxycholate + CoA
AMP + diphosphate + deoxycholoyl-CoA
-
-
-
-
?
additional information
?
-
-
the enzyme requires a C-24 bile acid with a free carboxyl group
-
-
?
additional information
?
-
-
the enzyme requires a C-24 bile acid with a free carboxyl group
-
-
?
additional information
?
-
-
enzyme additionally activates fatty acids
-
?
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ATP + 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanate + CoA
AMP + diphosphate + 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoyl-CoA
-
-
-
?
ATP + cholate + CoA
AMP + diphosphate + choloyl-CoA
ATP + cholate + CoA
AMP + diphosphate + choloyl-CoA
-
initial step in the bile acid 7alpha-dehydroxylation pathway
-
-
?
ATP + cholate + CoA
AMP + diphosphate + choloyl-CoA
-
initial step in the bile acid 7alpha-dehydroxylation pathway
-
-
?
ATP + cholate + CoA
AMP + diphosphate + choloyl-CoA
-
re-activation and re-conjugation of bile acids
-
?
ATP + cholate + CoA
AMP + diphosphate + choloyl-CoA
-
kidney has the potential for bile acid metabolism and may have a role in bile acid physiology. Conjugation of bile acids in the kidney may serve as a protective mechanism by which the renal cell avoids injury from circulating unconjugated bile acids
-
-
?
ATP + cholate + CoA
AMP + diphosphate + choloyl-CoA
-
choloyl-CoA synthetase is probably the rate limiting enzyme in the two-enzyme sequence catalyzing conjugation of bile acids
-
-
?
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Prydz, K.; Kase, B.F.; Bjoerkhem, I.; Pedersen, J.I.
Subcellular localization of 3alpha,7alpha-dihydroxy- and 3alpha,7alpha,12alpha-trihydroxy-5beta-cholastanoyl-coenzyme A ligase(s) in rat liver
J. Lipid Res.
29
997-1004
1988
Rattus norvegicus
brenda
Vessey, D.A.; Benfatto, A.M.; Zerweck, E.; Vestweber, C.
Purification and characterization of the enzymes of bile acid conjugation from fish liver
Comp. Biochem. Physiol. B
95
647-652
1990
Ophiodon elongatus, Sebastes miniatus, Sebastes pinniger
brenda
Mallonee, D.H.; Adams, J.L.; Hylemon, P.B.
The bile acid-inducible baiB gene from Eubacterium sp. strain VPI 12708 encodes a bile acid-coenzyme A ligase
J. Bacteriol.
174
2065-2071
1992
Eubacterium sp., Eubacterium sp. VPI 12708
brenda
Kelley, M.; Vessey, D.A.
Determination of the mechanism of reaction for bile acid:CoA ligase
Biochem. J.
304
945-949
1994
Cavia porcellus
brenda
Schepers, L.; Casteels, M.; Verheyden, K.; Parmentier, G.; Asselberghs, S.; Eyssen, H.J.; Mannaerts, G.P.
Subcellular distribution and characteristics of trihydroxycoprostanoyl-CoA synthetase in rat liver
Biochem. J.
257
221-229
1989
Rattus norvegicus
brenda
Van Veldhoven, P.P.; Asselberghs, S.; Eyssen, H.J.; Mannaerts, G.P.
Stabilisation and partial purification of Triton X-100 solubilised trihydroxycoprostanoyl-CoA synthetase from rat liver
Biochem. Mol. Biol. Int.
40
447-457
1996
Rattus norvegicus
brenda
Kwakye, J.B.; Barnes, S.; Diasio, R.B.
Identification of bile acid coenzyme A synthetase in rat kidney
J. Lipid Res.
34
95-99
1993
Rattus norvegicus
brenda
Kelley, M.; Vessey, D.A.
Dual role of divalent cations in the bile acid:CoA ligase catalyzed reaction
Biochim. Biophys. Acta
1209
51-55
1994
Cavia porcellus
brenda
Vessey, D.A.; Benfatto, A.M.
Chemical modification of bile acid: CoA ligase
Biochim. Biophys. Acta
1203
126-130
1993
Cavia porcellus
brenda
Vessey, D.A.; Erdman, A.; Kelley, M.; Claire, T.St.
A coupled assay for bile acid:CoA ligase
Anal. Biochem.
195
97-100
1991
Cavia porcellus
brenda
Simion, F.A.; Fleischer, B.; Fleischer, S.
Subcellular distribution of cholic acid:Coenzyme A ligase and deoxycholic acid:coenzyme A ligase activities in rat liver
Biochemistry
22
5029-5034
1983
Rattus norvegicus
brenda
Lim, W.C.; Jordan, T.W.
Subcellular distribution of hepatic bile acid-conjugation enzymes
Biochem. J.
197
611-618
1981
Rattus norvegicus
brenda
Kirkpatrick, R.B.; Robinson,S.F.; Killenberg, P.G.
Diurnal variation of rat liver enzymes catalyzing bile acid conjugation and sulfation
Biochim. Biophys. Acta
620
627-630
1980
Rattus norvegicus
brenda
Polokoff, M.A.; Coleman, R.A.; Bell, R.M.
Evidence that cholic acid CoA ligase is located asymetrically on the cytoplasmic surface of hepatic microsomal vesicles
J. Lipid Res.
20
17-21
1979
Rattus norvegicus
brenda
Vessey, D.A.; Zakim, D.
Characterization of microsomal choloyl-coenzyme A synthetase
Biochem. J.
163
357-362
1977
Cavia porcellus
brenda
Polokoff, M.A.; Bell, R.M.
Characterization of liver cholic acid coenzyme A ligase activity. Evidence that separate microsomal enzymes are responsible for cholic acid and fatty acid activation
J. Biol. Chem.
252
1167-1171
1977
Rattus norvegicus
brenda
Mallonee, D.H.; White, W.B.; Hylemon, P.B.
Cloning and sequencing of a bile acid-inducible operon from Eubacterium sp. Strain VPI 12708
J. Bacteriol.
172
7001-7019
1990
Eubacterium sp., Eubacterium sp. VPI 12708
-
brenda
stlund, A.K.; Nilsson, A.; Pedersen, J.I.
Human hepatoblastoma cells (HepG2) and rat hepatoma cells are defective in important enzyme activities in the oxidation of the C27 steroid side chain in bile acid formation
J. Lipid Res.
34
2041-2050
1993
no activity in Homo sapiens, Rattus norvegicus
brenda
Steinberg, S.J.; Mihalik, S.J.; Kim, D.G.; Cuebas, D.A.; Watkins, P.A.
The human liver-specific homolog of very long-chain acyl-CoA synthetase is cholate: CoA ligase
J. Biol. Chem.
275
15605-15608
2000
Homo sapiens
brenda
Wheeler, J.B.; Shaw, D.R.; Barnes, S.
Purification and characterization of a rat liver bile acid coenzyme A ligase from rat liver microsomes
Arch. Biochem. Biophys.
348
15-24
1997
Rattus norvegicus
brenda
Falany, C.N.; Xie, X.; Wheeler, J.B.; Wang, J.; Smith, M.; He, D.; Barnes, S.
Molecular cloning and expression of rat liver bile acid CoA ligase
J. Lipid Res.
43
2062-2071
2002
Rattus norvegicus
brenda
Hadzic, N.; Bull, L.N.; Clayton, P.T.; Knisely, A.S.
Diagnosis in bile acid-CoA: amino acid N-acyltransferase deficiency
World J. Gastroenterol.
18
3322-3326
2012
Homo sapiens
brenda