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Literature summary for 5.6.2.2 extracted from

  • Chen, W.; Shen, Y.; Li, Z.; Zhang, M.; Lu, C.; Shen, Y.
    Design and synthesis of 2-phenylnaphthalenoids as inhibitors of DNA topoisomeraseIIalpha and antitumor agents (2014), Eur. J. Med. Chem., 86, 782-796 .
    View publication on PubMed
Search for more literature for 5.6.2.2

Inhibitors

Inhibitors Comment Organism Structure
(3-(6-methoxynaphthalen-2-yl)phenyl)methanol
-
 Homo sapiens
(4-(6-methoxynaphthalen-2-yl)phenyl)methanol
-
 Homo sapiens
1-(2-hydroxy-5-(6-hydroxynaphthalen-2-yl)-3-nitrophenyl)ethanone
-
 Homo sapiens
1-(2-hydroxy-5-(6-methoxynaphthalen-2-yl)-3-nitrophenyl)ethanone
-
 Homo sapiens
1-(4-(6-methoxynaphthalen-2-yl)phenyl)ethanol
-
 Homo sapiens
2-(2-hydroxy-5-(6-hydroxynaphthalen-2-yl)phenyl)acetic acid
-
 Homo sapiens
2-(2-hydroxyethyl)-5-(6-methoxynaphthalen-2-yl)phenol
-
 Homo sapiens
2-(3,4-dimethoxyphenyl)-6-methoxynaphthalene
-
 Homo sapiens
2-(4-(6-methoxynaphthalen-2-yl)phenyl)acetic acid
-
 Homo sapiens
2-(6-hydroxynaphthalen-2-yl)-4-methylbenzoic acid
-
 Homo sapiens
2-acetoxy-5-(6-methoxynaphthalen-2-yl)benzyl acetate
-
 Homo sapiens
2-hydroxy-3-methoxy-5-(6-methoxynaphthalen-2-yl)benzaldehyde
-
 Homo sapiens
2-hydroxy-4-(6-hydroxynaphthalen-2-yl)benzoic acid
-
 Homo sapiens
2-hydroxy-5-(6-hydroxynaphthalen-2-yl )-3-methoxybenzaldehyde
-
 Homo sapiens
2-hydroxy-5-(6-hydroxynaphthalen-2-yl)benzaldehyde
-
 Homo sapiens
2-hydroxy-5-(6-hydroxynaphthalen-2-yl)benzoic acid
-
 Homo sapiens
2-hydroxy-5-(6-methoxynaphthalen-2-yl)benzoic acid
-
 Homo sapiens
2-methoxy-5-(6-methoxynaphthalen-2-yl)benzaldehyde
-
 Homo sapiens
2-methoxy-6-(3-(trifluoromethyl)phenyl)naphthalene
-
 Homo sapiens
2-methoxy-6-(4-(trifluoromethyl)phenyl)naphthalene
-
 Homo sapiens
2-methoxy-6-(4-nitro-3-(trifluoromethyl)phenyl)naphthalene
-
 Homo sapiens
4-(6-hydroxynaphthalen-2-yl)benzene-1,2-diol
-
 Homo sapiens
4-(6-methoxynaphthalen-2-yl)-2-methylaniline
-
 Homo sapiens
4-(6-methoxynaphthalen-2-yl)aniline
-
 Homo sapiens
4-(6-methoxynaphthalen-2-yl)phenol
-
 Homo sapiens
4-hydroxy-3-(6-hydroxynaphthalen-2-yl)benzaldehyde
-
 Homo sapiens
4-hydroxy-3-(6-methoxynaphthalen-2-yl)benzaldehyde
-
 Homo sapiens
6-(3,4-dimethoxyphenyl)naphthalen-2-ol
-
 Homo sapiens
6-(3-(hydroxymethyl)phenyl)naphthalen-2-ol
-
 Homo sapiens
6-(4-(1-hydroxyethyl)phenyl)naphthalen-2-ol
-
 Homo sapiens
6-(4-(hydroxymethyl)phenyl)naphthalen-2-ol
-
 Homo sapiens
6-(4-amino-3-methylphenyl)naphthalen-2-ol
-
 Homo sapiens
6-(4-aminophenyl)naphthalen-2-ol
-
 Homo sapiens
6-(4-hydroxy-3-(2-hydroxyethyl)phenyl)naphthalen-2-ol
-
 Homo sapiens
6-(4-hydroxy-3-(hydroxymethyl)phenyl)naphthalen-2-ol
-
 Homo sapiens
6-(4-hydroxyphenyl)naphthalen-2-ol
-
 Homo sapiens
6-(4-nitro-3-(trifluoromethyl)phenyl)naphthalen-2-ol
-
 Homo sapiens
etoposide
-
 Homo sapiens
methyl 2-(2-hydroxy-4-(6-methoxynaphthalen-2-yl)phenyl)acetate
-
 Homo sapiens
methyl 2-(2-hydroxy-5-(6-hydroxynaphthalen-2-yl)phenyl)acetate
-
 Homo sapiens
methyl 2-(4-(6-methoxynaphthalen-2-yl)phenyl)acetate
-
 Homo sapiens
methyl 2-hydroxy-2-(4-(6-methoxynaphthalen-2-yl)phenyl)acetate
-
 Homo sapiens
methyl 2-hydroxy-4-(6-methoxynaphthalen-2-yl)benzoate
-
 Homo sapiens
methyl 2-hydroxy-5-(6-methoxynaphthalen-2-yl)benzoate
-
 Homo sapiens
methyl 3-(6-hydroxynaphthalen-2-yl)-4-methylbenzoate
-
 Homo sapiens
methyl 3-(6-methoxynaphthalen-2-yl)-4-methylbenzoate
-
 Homo sapiens
methyl 4-(6-methoxynaphthalen-2-yl)benzoate
-
 Homo sapiens
methyl 4-hydroxy-3-(6-hydroxynaphthalen-2-yl)benzoate
-
 Homo sapiens
methyl 4-hydroxy-3-(6-methoxynaphthalen-2-yl)benzoate
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
supercoiled pBR322 DNA + ATP + H2O Homo sapiens
-
 relaxed pBR322 DNA + ADP + phosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens P11388
-
-

Source Tissue

Source Tissue Comment Organism Textmining
A-549 cell
-
 Homo sapiens
-
HeLa cell
-
 Homo sapiens
-
MDA-MB-231 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
supercoiled pBR322 DNA + ATP + H2O
-
 Homo sapiens relaxed pBR322 DNA + ADP + phosphate
-
 ?

Synonyms

Synonyms Comment Organism
DNA topoisomeraseIIalpha
-
 Homo sapiens
topoIIalpha
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
ATP dependent on Homo sapiens