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Literature summary for 5.6.2.2 extracted from
- Topoisomerase II alpha is required for embryonic development and liver regeneration in zebrafish (2009), Mol. Cell. Biol., 29, 3746-3753.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| gene can4, endogenous expression pattern of top2a during development, overview | Danio rerio |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| additional information | a gene can4 mutant shows impaired embryonal development, phenotype, overview | Danio rerio |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| nucleus | - |
Danio rerio | 5634 | - |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Danio rerio | top2a is required for decatenation but not for condensation in embryonic mitoses | ? | - |
? |  |
| additional information | Danio rerio AB | top2a is required for decatenation but not for condensation in embryonic mitoses | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Danio rerio | - |
gene can4 | - |
| Danio rerio AB | - |
gene can4 | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| embryo | endogenous expression pattern of top2a during development, overview | Danio rerio | - |
| liver | - |
Danio rerio | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | top2a is required for decatenation but not for condensation in embryonic mitoses | Danio rerio | ? | - |
? | |
| additional information | top2a is required for decatenation but not for condensation in embryonic mitoses | Danio rerio AB | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| top2a | - |
Danio rerio |
| topoisomerase II alpha | - |
Danio rerio |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | topoisomerase II alpha is required for embryonic development and liver regeneration, it is a haploinsufficient regulator of adult liver regrowth, but not of other adult tissues | Danio rerio |
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