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Literature summary for 5.6.2.2 extracted from

  • Stuchinskaya, T.; Mitchenall, L.A.; Schoeffler, A.J.; Corbett, K.D.; Berger, J.M.; Bates, A.D.; Maxwell, A.
    How do type II topoisomerases use ATP hydrolysis to simplify DNA topology beyond equilibrium? Investigating the relaxation reaction of nonsupercoiling type II topoisomerases (2008), J. Mol. Biol., 385, 1397-1408.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 5.6.2.2

Organism

Organism UniProt Comment Textmining
Escherichia coli
-
-
-
Homo sapiens
-
-
-
Saccharomyces cerevisiae
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
supercoiled DNA + ATP + H2O
-
 Escherichia coli catenated DNA networks + ADP + phosphate
-
 ?
supercoiled DNA + ATP + H2O
-
 Homo sapiens catenated DNA networks + ADP + phosphate
-
 ?
supercoiled DNA + ATP + H2O
-
 Saccharomyces cerevisiae catenated DNA networks + ADP + phosphate
-
 ?

Synonyms

Synonyms Comment Organism
topo II
-
 Saccharomyces cerevisiae
Topo IIalpha isoform Homo sapiens
Topo IIbeta isoform Homo sapiens
topo IV
-
 Escherichia coli
Topoisomerase II
-
 Homo sapiens
Topoisomerase II
-
 Saccharomyces cerevisiae
topoisomerase IV
-
 Escherichia coli

Cofactor

Cofactor Comment Organism Structure
ATP all nonsupercoiling type II topoisomerases require ATP hydrolysis for relaxation Escherichia coli
ATP all nonsupercoiling type II topoisomerases require ATP hydrolysis for relaxation Homo sapiens
ATP all nonsupercoiling type II topoisomerases require ATP hydrolysis for relaxation Saccharomyces cerevisiae