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Literature summary for 5.6.2.2 extracted from
- Evidence for the presence of R250G mutation at the ATPase domain of topoisomerase II in an arsenite-resistant Leishmania donovani exhibiting a differential drug inhibition profile (2009), Int. J. Antimicrob. Agents, 33, 80-85.
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| R250G | point mutation in the ATPase domain of topo II leading to arsenite resistance | Leishmania donovani |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| actinomycin D | - |
Leishmania donovani |  |
| arsenite | - |
Leishmania donovani | |
| doxorubicin | - |
Leishmania donovani | |
| novobiocin | - |
Leishmania donovani | |
| Pentamidine | - |
Leishmania donovani | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Leishmania donovani | Q9XZN0 | - |
- |
| Leishmania donovani MHOM/80/IN/Dd8 | Q9XZN0 | - |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| partially purified | Leishmania donovani |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| supercoiled DNA + ATP + H2O | - |
Leishmania donovani | catenated DNA networks + ADP + phosphate | - |
? | |
| supercoiled DNA + ATP + H2O | - |
Leishmania donovani MHOM/80/IN/Dd8 | catenated DNA networks + ADP + phosphate | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| topo II | - |
Leishmania donovani |
| Topoisomerase II | - |
Leishmania donovani |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| ATP | - |
Leishmania donovani | |
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Release 2023.1 (January 2023)
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