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Literature summary for 5.6.2.2 extracted from

  • Linka, R.M.; Porter, A.C.; Volkov, A.; Mielke, C.; Boege, F.; Christensen, M.O.
    C-terminal regions of topoisomerase IIalpha and IIbeta determine isoform-specific functioning of the enzymes in vivo (2007), Nucleic Acids Res., 35, 3810-3822.
    View publication on PubMedView publication on EuropePMC
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Protein Variants

Protein Variants Comment Organism
additional information exchange of the two divergent C-terminal regions of the isoforms IIalpha and IIbeta. Complementation of a conditional isoform IIalpha knock-out mutant cell is fully supported by all enzymes bearing the alpha C-terminal regions. The alpha C-terminal regions also promotes chromosome binding of both enzyme cores. enzymes bearing the beta C-terminal core support proliferation only rarely and when expressed at unusually high levels Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
 isoforms IIalpha and IIbeta
-