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Literature summary for 5.6.2.2 extracted from

  • Yamada, M.; Hayashi, K.; Ikeda, S.; Tsutsui, K.; Tsutsui, K.; Ito, T.; Iinuma, M.; Nozaki, H.
    Inhibitory activity of plant stilbene oligomers against DNA topoisomerase II (2006), Biol. Pharm. Bull., 29, 1504-1507.
    View publication on PubMed
Search for more literature for 5.6.2.2

Inhibitors

Inhibitors Comment Organism Structure
(1R,1'R,6S,6'S,7R,7'R,11bR,11b'R)-1,1',7,7'-tetrakis(4-hydroxyphenyl)-1,1',6,6',7,7',11b,11b'-octahydro-6,6'-bi-2-oxadibenzo[cd,h]azulene-4,4',8,8',10,10'-hexol comparison with inhibition of HindIII enzyme Homo sapiens
(1R,1'R,6S,6'S,7S,7'S,11bR,11b'R)-1,1',7,7'-tetrakis(4-hydroxyphenyl)-1,1',6,6',7,7',11b,11b'-octahydro-6,6'-bi-2-oxadibenzo[cd,h]azulene-4,4',8,8',10,10'-hexol comparison with inhibition of HindIII enzyme Homo sapiens
(2R,2'S,3'S)-3'-(3,5-dihydroxyphenyl)-2,2'-bis(4-hydroxyphenyl)-4-[(E)-2-(4-hydroxyphenyl)ethenyl]-2,2',3,3'-tetrahydro-3,4'-bi-1-benzofuran-6,6'-diol comparison with inhibition of HindIII enzyme Homo sapiens
(2R,3S)-2-(3,5-dihydroxyphenyl)-1-[(S)-hydroxy(4-hydroxyphenyl)methyl]-3-(4-hydroxyphenyl)-2,3-dihydro-1H-indene-4,6-diol comparison with inhibition of HindIII enzyme Homo sapiens
(3R,4R,4aS,5S,9bS,10S)-4-(3,5-dihydroxyphenyl)-3,5,10-tris(4-hydroxyphenyl)-3,4,4a,5,9b,10-hexahydro-11-oxabenzo[5,6]cyclohepta[1,2,3,4-jkl]-as-indacene-2,6,8-triol comparison with inhibition of HindIII enzyme Homo sapiens
(3S,4S,4aR,5S,9bS,10S)-4-(3,5-dihydroxyphenyl)-3,5,10-tris(4-hydroxyphenyl)-3,4,4a,5,9b,10-hexahydro-11-oxabenzo[5,6]cyclohepta[1,2,3,4-jkl]-as-indacene-2,6,8-triol comparison with inhibition of HindIII enzyme Homo sapiens
(4bR,5R,9S,10S,11R,12R)-10-(3,5-dihydroxyphenyl)-5,9,12-tris(4-hydroxyphenyl)-4b,5,9,10,11,12-hexahydrobenzo[6,7]cyclohepta[1,2,3-cd]furo[3,2-f][1]benzofuran-1,3,11-triol comparison with inhibition of HindIII enzyme Homo sapiens
alpha-viniferin-13-O-beta-glucopyranoside comparison with inhibition of HindIII enzyme Homo sapiens
daunorubicin comparison with inhibition of HindIII enzyme Homo sapiens
hemsleyanol comparison with inhibition of HindIII enzyme Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
 topoisomerase II, commercial product
-

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
1
-
 pH 7.9, 30°C Homo sapiens hemsleyanol
3
-
 pH 7.9, 30°C Homo sapiens (3R,4R,4aS,5S,9bS,10S)-4-(3,5-dihydroxyphenyl)-3,5,10-tris(4-hydroxyphenyl)-3,4,4a,5,9b,10-hexahydro-11-oxabenzo[5,6]cyclohepta[1,2,3,4-jkl]-as-indacene-2,6,8-triol
4
-
 pH 7.9, 30°C Homo sapiens alpha-viniferin-13-O-beta-glucopyranoside
4
-
 pH 7.9, 30°C Homo sapiens (1R,1'R,6S,6'S,7S,7'S,11bR,11b'R)-1,1',7,7'-tetrakis(4-hydroxyphenyl)-1,1',6,6',7,7',11b,11b'-octahydro-6,6'-bi-2-oxadibenzo[cd,h]azulene-4,4',8,8',10,10'-hexol
5
-
 pH 7.9, 30°C Homo sapiens (4bR,5R,9S,10S,11R,12R)-10-(3,5-dihydroxyphenyl)-5,9,12-tris(4-hydroxyphenyl)-4b,5,9,10,11,12-hexahydrobenzo[6,7]cyclohepta[1,2,3-cd]furo[3,2-f][1]benzofuran-1,3,11-triol
5
-
 pH 7.9, 30°C Homo sapiens (2R,2'S,3'S)-3'-(3,5-dihydroxyphenyl)-2,2'-bis(4-hydroxyphenyl)-4-[(E)-2-(4-hydroxyphenyl)ethenyl]-2,2',3,3'-tetrahydro-3,4'-bi-1-benzofuran-6,6'-diol
6
-
 pH 7.9, 30°C Homo sapiens (1R,1'R,6S,6'S,7R,7'R,11bR,11b'R)-1,1',7,7'-tetrakis(4-hydroxyphenyl)-1,1',6,6',7,7',11b,11b'-octahydro-6,6'-bi-2-oxadibenzo[cd,h]azulene-4,4',8,8',10,10'-hexol
6
-
 pH 7.9, 30°C Homo sapiens (3S,4S,4aR,5S,9bS,10S)-4-(3,5-dihydroxyphenyl)-3,5,10-tris(4-hydroxyphenyl)-3,4,4a,5,9b,10-hexahydro-11-oxabenzo[5,6]cyclohepta[1,2,3,4-jkl]-as-indacene-2,6,8-triol
7
-
 pH 7.9, 30°C Homo sapiens (2R,3S)-2-(3,5-dihydroxyphenyl)-1-[(S)-hydroxy(4-hydroxyphenyl)methyl]-3-(4-hydroxyphenyl)-2,3-dihydro-1H-indene-4,6-diol
8.5
-
 pH 7.9, 30°C Homo sapiens daunorubicin