Literature summary for 5.6.2.2 extracted from

Mandraju, R.K.; Kannapiran, P.; Kondapi, A.K.
Distinct roles of Topoisomerase II isoforms: DNA damage accelerating alpha, double strand break repair promoting beta (2008), Arch. Biochem. Biophys., 470, 27-34.

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Protein Variants

Protein Variants	Comment	Organism
additional information	cells lacking isoform TopoIIalpha activity are resistant to peroxide-mediated DNA damage, while cells lacking isoform TopoIIbeta are 2fold more sensitive to peroxide and TopoIIbeta deficiency leads to cellular apoptosis	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	isoforms TopoIIalpha and TopoIIbeta	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
astrocytoma cell	strong correlation of isoform TopoIIalpha level with the progression of DNA damage after peroxide-mediated DNA damage and double-strand breaks. Isoform TopoIIbeta expression is correlated with the DNA double strand breaks repair activity of cells in Ku70, Werners helicase and pol-beta dependent pathways	Homo sapiens	-
neuroblastoma cell	-	Homo sapiens	-

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Release 2023.1 (January 2023)