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Literature summary for 5.6.2.2 extracted from

  • Fellows, I.M.; Schwaebe, M.; Dexheimer, T.S.; Vankayalapati, H.; Gleason-Guzman, M.; Whitten, J.P.; Hurley, L.H.
    Determination of the importance of the stereochemistry of psorospermin in topoisomerase II-induced alkylation of DNA and in vitro and in vivo biological activity (2005), Mol. Cancer Ther., 4, 1729-1739.
    View publication on PubMed
Search for more literature for 5.6.2.2

Application

Application Comment Organism
pharmacology the enzyme induces antitumor activity of alkylating reagent psorospermin and analogues rendering them utilizable for cancer therapy Mus musculus
pharmacology the enzyme induces antitumor activity of alkylating reagent psorospermin and analogues rendering them utilizable for cancer therapy Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Mus musculus the enzyme induces the activity of psorospermin, O5-methyl-psorospermin, and gemcitabine alkylating DNA through an epoxide-mediated electrophilic attack, at some DNA sites leading to increased antitumor activity of the alkylating reagents ?
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 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
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-
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Mus musculus
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-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information the enzyme induces the activity of psorospermin, O5-methyl-psorospermin, and gemcitabine alkylating DNA through an epoxide-mediated electrophilic attack, at some DNA sites leading to increased antitumor activity of the alkylating reagents Mus musculus ?
-
 ?
additional information the enzyme enhances the activity of psorospermin, O5-methyl-psorospermin, and gemcitabine, alkylating DNA through an epoxide-mediated electrophilic attack, at some DNA sites, overview Homo sapiens ?
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 ?

Synonyms

Synonyms Comment Organism
Topoisomerase II
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 Mus musculus
Topoisomerase II
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 Homo sapiens