Literature summary for 5.6.2.2 extracted from

Sakemi, S.; Inagaki, T.; Kaneda, K.; Hirai, H.; Iwata, E.; Sakakibara, T.; Yamauchi, Y.; Norcia, M.; Wondrack, L.M.; Sutcliffe, J.A.
CJ-12,371 and CJ-12,372, two novel DNA gyrase inhibitors. Fermentation, isolation, structural elucidation and biological activities (1995), J. Antibiot., 48, 134-142.

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Inhibitors

Inhibitors	Comment	Organism	Structure
CJ-12,371	inhibits both DNA supercoiling and relaxation without blocking religation, the inhibitor is isolated from the fermentation broth of an unidentified fungus	Escherichia coli
CJ-12,372	inhibits both DNA supercoiling and relaxation without blocking religation, the inhibitor is isolated from the fermentation broth of an unidentified fungus	Escherichia coli

Organism

Organism	UniProt	Comment	Textmining
Escherichia coli	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
network of DNA rings + ATP + H2O	decatenation	Escherichia coli	monomeric DNA circles + ADP + phosphate	-	?
supercoiled DNA + ATP + H2O	catenation	Escherichia coli	catenated DNA networks + ADP + phosphate	-	?
supercoiled DNA + ATP + H2O	relaxation	Escherichia coli	relaxed DNA + ADP + phosphate	-	?

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Release 2023.1 (January 2023)