Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | - |
Homo sapiens | |
additional information | modification by poly(ADP)ribosylation | eukaryota | |
additional information | casein kinase II and protein kinase C phosphorylate topoisomerase II. Phosphorylation produces a 2-3fold increase in the catalytic activity | eukaryota |
Application | Comment | Organism |
---|---|---|
pharmacology | antitumor effect of inhibitors | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
isoform IIalpha and isoform IIbeta | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
4'-(9-acridinylamino)methansulfon-m-anisidide | and related quinoline carboxamides | eukaryota | |
Aclarubicin | - |
eukaryota | |
actinomycins | - |
Homo sapiens | |
Ametantrone | - |
eukaryota | |
aurintricarboxylic acid | - |
Homo sapiens | |
aurintricarboxylic acid | - |
Saccharomyces cerevisiae | |
Barminomycin-like anthracyclines | - |
Homo sapiens | |
Benzisoquinolinediones | - |
Homo sapiens | |
Bisantrene | efficiency in patients with breast cancer and acute leukemia | Homo sapiens | |
Bisdioxopiperazines | - |
eukaryota | |
Bisdioxopiperazines | - |
Mammalia | |
carminamycin | - |
eukaryota | |
daunorubicin | - |
eukaryota | |
Demethylepipodophyllotoxins | - |
eukaryota | |
doxorubicin | - |
Saccharomyces cerevisiae | |
ellipticines | - |
eukaryota | |
ellipticines | - |
Homo sapiens | |
fostriecin | - |
eukaryota | |
genistein | - |
eukaryota | |
idarubicin | - |
eukaryota | |
idarubicin | - |
Homo sapiens | |
isoflavones | - |
eukaryota | |
Merbarone | - |
eukaryota | |
Merocil | - |
Homo sapiens | |
Merodantoin | - |
Homo sapiens | |
Mitoxantrone | - |
eukaryota | |
additional information | - |
eukaryota | |
additional information | antitumor effect of inhibitors | Homo sapiens | |
additional information | - |
Saccharomyces cerevisiae | |
N-Trifluoroacetyldoxorubicin-14 valerate | - |
Homo sapiens | |
Pirarubicin | - |
eukaryota | |
Pirarubicin | - |
Homo sapiens | |
quinolones | - |
eukaryota |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | eukaryota | enzyme plays a key role in DNA replication and transcription. Required for chromosome segregation during meiosis and mitosis | ? | - |
? | |
additional information | Homo sapiens | isoenzyme IIalpha is expressed at the highest level during rapid proliferation, isoenzyme IIbeta is expressed maximally in cells that have reached the plateau phase of growth | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
eukaryota | - |
- |
- |
Homo sapiens | - |
2 isoenzymes: IIalpha and IIbeta | - |
Mammalia | - |
- |
- |
Saccharomyces cerevisiae | - |
- |
- |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
ATP-dependent breakage, passage and rejoining of double-stranded DNA | the catalytic cycle of topoisomerase II consists of 5 distinct steps: DNA binding, the pre-strand passage breakage-religation equilibrium, strand passage, the post-strand passage breakage-religation equilibrium and ATP hydrolysis/enzyme turnover | eukaryota |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | - |
Saccharomyces cerevisiae | ? | - |
? | |
additional information | no formation of negative supercoils | eukaryota | ? | - |
? | |
additional information | enzyme plays a key role in DNA replication and transcription. Required for chromosome segregation during meiosis and mitosis | eukaryota | ? | - |
? | |
additional information | isoenzyme IIalpha is expressed at the highest level during rapid proliferation, isoenzyme IIbeta is expressed maximally in cells that have reached the plateau phase of growth | Homo sapiens | ? | - |
? | |
network of DNA rings + ATP + H2O | decatenation | Mammalia | monomeric DNA circles + ADP + phosphate | - |
? | |
network of DNA rings + ATP + H2O | decatenation | eukaryota | monomeric DNA circles + ADP + phosphate | - |
? | |
network of DNA rings + ATP + H2O | decatenation | Homo sapiens | monomeric DNA circles + ADP + phosphate | - |
? | |
network of DNA rings + ATP + H2O | decatenation | Saccharomyces cerevisiae | monomeric DNA circles + ADP + phosphate | - |
? | |
supercoiled DNA + ATP + H2O | catenation | Mammalia | catenated DNA networks + ADP + phosphate | - |
? | |
supercoiled DNA + ATP + H2O | catenation | eukaryota | catenated DNA networks + ADP + phosphate | - |
? | |
supercoiled DNA + ATP + H2O | catenation | Homo sapiens | catenated DNA networks + ADP + phosphate | - |
? | |
supercoiled DNA + ATP + H2O | catenation | Saccharomyces cerevisiae | catenated DNA networks + ADP + phosphate | - |
? | |
supercoiled DNA + ATP + H2O | relaxation | Mammalia | relaxed DNA + ADP + phosphate | - |
? | |
supercoiled DNA + ATP + H2O | relaxation | eukaryota | relaxed DNA + ADP + phosphate | - |
? | |
supercoiled DNA + ATP + H2O | relaxation | Homo sapiens | relaxed DNA + ADP + phosphate | - |
? | |
supercoiled DNA + ATP + H2O | relaxation | Saccharomyces cerevisiae | relaxed DNA + ADP + phosphate | - |
? | |
supercoiled DNA + ATP + H2O | ATP-dependent relaxation of negative and positive supercoils | eukaryota | relaxed DNA + ADP + phosphate | - |
? | |
supercoiled DNA + ATP + H2O | under optimal conditions the enzyme relaxes all supercoils prior to dissociation of the enzyme from DNA | eukaryota | relaxed DNA + ADP + phosphate | - |
? |