Literature summary for 4.6.1.23 extracted from

Citores, L.; Ragucci, S.; Ferreras, J.M.; Di Maro, A.; Iglesias, R.
Ageritin, a ribotoxin from poplar mushroom (Agrocybe aegerita) with defensive and antiproliferative activities (2019), ACS Chem. Biol., 14, 1319-1327 .

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Organism

Organism	UniProt	Comment	Textmining
Cyclocybe aegerita	C0HLG3	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
23S rRNA containing guanosine-adenosine pair + H2O	-	Cyclocybe aegerita	an [RNA fragment]-3'-adenosine-3'-phosphate + a 5'-a hydroxy-guanosine-3'-[RNA fragment]	-	?

General Information

General Information	Comment	Organism
physiological function	ageritin displayed antibacterial activity against Micrococcus lysodeikticus, activity against the tobacco mosaic virus RNA, endonuclease activity against a supercoiled plasmid, nuclease activity against genomic DNA, cytotoxicity to COLO 320, HeLa, and Raji cells by promoting apoptosis, and antifungal activity against the green mold Penicillium digitatum	Cyclocybe aegerita

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Release 2023.1 (January 2023)