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Literature summary for 4.2.1.123 extracted from
- Squalene-hopene cyclases (2011), Appl. Environ. Microbiol., 77, 3905-3915.
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.018 | - |
squalene | pH 7.0, 30°C | Tetrahymena thermophila |  |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 72000 | - |
x * 72000, SDS-PAGE | Tetrahymena thermophila |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| squalene + H2O | Tetrahymena thermophila | - |
tetrahymanol | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| no activity in Alicyclobacillus acidocaldarius | - |
- |
- |
| no activity in Bradyrhizobium japonicum | - |
- |
- |
| no activity in Methylococcus capsulatus | - |
- |
- |
| no activity in Rhodopseudomonas palustris | - |
- |
- |
| Tetrahymena thermophila | - |
- |
- |
Reaction
| Reaction | Comment | Organism | Reaction ID |
|---|---|---|---|
| tetrahymanol = squalene + H2O | overall mechanism of the polycyclization reaction of SHCs and structures of squalene cyclization products, overview | Tetrahymena thermophila |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| squalene + H2O | - |
Tetrahymena thermophila | tetrahymanol | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| ? | x * 72000, SDS-PAGE | Tetrahymena thermophila |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| squalene-tetrahymanol cyclase | - |
Tetrahymena thermophila |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 30 | - |
- |
Tetrahymena thermophila |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7 | - |
- |
Tetrahymena thermophila |
General Information
| General Information | Comment | Organism |
|---|---|---|
| metabolism | the enzyme converts squalene to tetrahymanol, EC 4.2.1.123, and to hopanol, EC 4.2.1.129, pathway overview | Tetrahymena thermophila |
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Release 2023.1 (January 2023)
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