Cloned (Comment) | Organism |
---|---|
heterologous expression of RhoA in Xenopus laevis oocytes. Expression of constitutively active RhoA in primary culture of spinal motoneurons also drastically reduces high-voltage-activated Ca2+ current amplitude | Mus musculus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | RhoA- or ROCK-induced inhibitions are partially relieved upon incubation of the oocytes with the ROCK inhibitor Y27632 | Mus musculus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
plasma membrane | - |
Mus musculus | 5886 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
GTP + H2O | Mus musculus | - |
GDP + phosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | Q9QUI0 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
neuron | constitutively active RhoA in primary culture of spinal motoneurons | Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
GTP + H2O | - |
Mus musculus | GDP + phosphate | - |
? | |
additional information | recombinant RhoA activity reduces Ba2+ currents through CaV2.1, CaV2.2 and CaV2.3 Ca2+ channels independently of CaVbeta subunit. This inhibition occurs independently of RGKs activity and without modification of biophysical properties and global level of expression of the channel subunit | Mus musculus | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
RhoA | - |
Mus musculus |
small GTPase | - |
Mus musculus |
General Information | Comment | Organism |
---|---|---|
malfunction | expression of constitutively active RhoA in primary culture of spinal motoneurons also drastically reduces high-voltage-activated Ca2+ current amplitude | Mus musculus |
metabolism | high-voltage-activated Ca2+ channels are known regulators of synapse formation and transmission and play fundamental roles in neuronal pathophysiology. Small GTPases of Rho and RGK families, via their action on both cytoskeleton and Ca2+ channels are key molecules for these processes | Mus musculus |
physiological function | RhoA inhibits HVA CaV2 Ca2+ channels in a CaVbeta subunit-independent manner, recombinant RhoA activity reduces Ba2+ currents through CaV2.1, CaV2.2 and CaV2.3 Ca2+ channels independently of CaVbeta subunit. This inhibition occurs independently of RGKs activity and without modification of biophysical properties and global level of expression of the channel subunit. High-voltage-activated Ca2+ channels regulation by RhoA might govern synaptic transmission during development and potentially contribute to pathophysiological processes when axon regeneration and growth cone kinetics are impaired. Effects of RhoA on CaV2 trafficking to the plasma membrane, regulation of Ca2+ channel expression and activity by small GTPases, overview | Mus musculus |