Literature summary for 3.5.4.37 extracted from

Tang, Y.D.; Na, L.; Fu, L.H.; Yang, F.; Zhu, C.H.; Tang, L.; Li, Q.; Wang, J.Y.; Li, Z.; Wang, X.F.; Li, C.Y.; Wang, X.; Zhou, J.H.
Double-stranded RNA-specific adenosine deaminase 1 (ADAR1) promotes EIAV replication and infectivity (2015), Virology, 476, 364-371 .

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Cloned(Commentary)

Cloned (Comment)	Organism
equine ADAR1 (eADAR1) cDNA is cloned from mRNA extracted from eMDMs and expressed using the adenoviral expression vector pDC315	Equus sp.

Organism

Organism	UniProt	Comment	Textmining
Equus sp.	-	-	-

Synonyms

Synonyms	Comment	Organism
ADAR1	-	Equus sp.
double-stranded RNA-specific adenosine deaminase 1	-	Equus sp.

General Information

General Information	Comment	Organism
physiological function	equine ADAR1 (eADAR1) is a positive regulator of equine infectious anemia virus (EIAV). eADAR1 significantly promotes EIAV replication, and the enhancement of viral protein expression is associated with the long terminal repeat (LTR) and Rev response element regions. The RNA binding domain 1 of eADAR1 is essential only for enhancing LTR-mediated gene expression. eADAR1 increases the EIAV infectivity	Equus sp.

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Release 2023.1 (January 2023)